Patents by Inventor David T. Hill

David T. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphinegold (I) salts having antiarthritic activity
    Patent number: 4171360
    Abstract: The compounds are (pyridine) (trisubstituted phosphine) gold(I) salts which have antiarthritic activity.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Bis(sulfide)gold(1+) salts
    Patent number: 4165380
    Abstract: The compounds are bis(sulfide)gold(1+) salts which have antiarthritic activity.
    Type: Grant
    Filed: June 2, 1978
    Date of Patent: August 21, 1979
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • 6-Hydroxy-5,6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles
    Patent number: 4153706
    Abstract: The compounds are 6-hydroxy-5,6-substituted-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles which have antiarthritic activity and are useful as intermediates for preparing 2,3-dihydroimidazo[2,1-b]thiazole antiarthritic compounds. A particular compound of this invention is 5,6-bis-(p-fluorophenyl)-6-hydroxy-2,3,5,6-tetrahydroimidazo[2,1-b]thiazol e.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: May 8, 1979
    Assignee: SmithKline Corporation
    Inventors: Paul E. Bender, David T. Hill
  • Process and intermediate for preparing auranofin
    Patent number: 4133952
    Abstract: The S-gold salt of 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose reacts with triethylphosphine in an organic solvent to produce auranofin.
    Type: Grant
    Filed: June 10, 1977
    Date of Patent: January 9, 1979
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Method for preparing auranofin
    Patent number: 4131732
    Abstract: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with triethylphosphinegold(I) chloride and sodium or potassiumsulfide. Auranofin is an antiarthritic pharmaceutical compound. Auranofin is an orally active therapeutic agent which is useful in man as an antiarthritic.
    Type: Grant
    Filed: April 21, 1977
    Date of Patent: December 26, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Blaine M. Sutton, Ivan Lantos
  • Method for preparing auranofin
    Patent number: 4125710
    Abstract: Bis(triethylphosphine)gold salts are advantageous agents for preparing auranofin.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: November 14, 1978
    Assignee: Smithkline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Process for preparing auranofin
    Patent number: 4125711
    Abstract: Auranofin is prepared by reacting 1-.beta.-D-thio-2,3,4,6-tetra-O-acetylglucose with a triethylphosphine gold mercaptide.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: November 14, 1978
    Assignee: Smithkline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Preparation of auranofin by O-acetylation
    Patent number: 4124759
    Abstract: Auranofin is prepared by direct O-acetylation of S-triethylphosphinegold 1-thio-.beta.-D-glucopyranoside.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: November 7, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Process for preparing auranofin
    Patent number: 4122254
    Abstract: Auranofin and its congeners are prepared by the reaction of a S-substituted 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose with a tertiary phosphine gold ester or sulfide.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: October 24, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Method for preparing auranofin
    Patent number: 4115642
    Abstract: Auranofin and its congeners are prepared by reacting a bis(polyacetylsaccharide)disulfide with a tertiary phosphinegold mercaptide in a suitable organic solvent.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: September 19, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Bis(sulfide)gold(1+) salts
    Patent number: 4112113
    Abstract: The compounds are bis(sulfide)gold(1+) salts which have antiarthritic activity.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: September 5, 1978
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Pharmaceutical compositions and methods of producing antiarthritic activity with bis(pyridine)gold(1+) salts
    Patent number: 4098887
    Abstract: Pharmaceutical compositions and methods of producing antiarthritic activity with bis(pyridine)gold(1+) salts.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: July 4, 1978
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Tri-substituted phosphinegold(I) 1-thio-.beta.-D-glucopyranosides
    Patent number: 4096250
    Abstract: The compounds are tri-substituted phosphinegold(I) 1-thio-.beta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis. Of the three substituents on the phosphine one is optionally substituted phenyl and the others are lower alkyl or lower alkoxy.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • Substituted cyano,trifluoromethylphenyl linear triazenes
    Patent number: 3976633
    Abstract: The compounds of this invention are substituted cyano,trifluoromethylphenyl linear triazenes having pharmacological activity. In particular, these compounds have anorectic and anti-obesity activity. A preferred compound is 1,3-bis(2-cyano-5-trifluoromethylphenyl)triazene.
    Type: Grant
    Filed: June 3, 1974
    Date of Patent: August 24, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, David T. Hill, Bernard Loev
  • Pharmaceutical compositions and methods of producing coronary vasodilation
    Patent number: 3975537
    Abstract: Pharmaceutical compositions and methods of producing coronary vasodilation by administering substituted benzofurans, for example 2-n-butyl-3-[4' -(2-hydroxy-3-isopropylamino)propoxybenzoyl] benzofuran.
    Type: Grant
    Filed: February 20, 1975
    Date of Patent: August 17, 1976
    Assignee: Smith Kline
    Inventors: David T. Hill, Bernard Loev