Patents by Inventor David T. MacLaughkin

David T. MacLaughkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of Mullerian inhibiting substance
    Patent number: 5310880
    Abstract: The present invention discloses a method of purifying Mullerian Inhibiting Substance. The method takes advantage of immunoaffinity chromatography to achieve MIS at up to 95% purity. The method provides for a purified MIS product in which contaminating enzymes having MIS proteolytic activity or inhibitors of MIS antiproliferative activity are substantially removed by addition of an alkali metal halide solution or an alkaline earth metal halide solution prior to elution with an acid solution having a pH of between about 2.5 and 4.0.
    Type: Grant
    Filed: April 12, 1991
    Date of Patent: May 10, 1994
    Assignee: The General Hospital Corporation
    Inventors: Patricia K. Donahoe, Richard C. Ragin, David T. MacLaughkin