Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-C toxin.

Abstract: This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-C toxin.

Abstract: A method of detecting the type of optical disc inserted in an optical disc player including the steps of: i) attempting to focus a laser read head on the disc using a first set of player parameters appropriate for a first type of disc; ii) if focus is obtained: a) reading data from the disc and determining whether a sub-code representative of a second type of disc is present; b) if so changing the first set of player parameters to a second set of player parameters appropriate to a second type of disc; c) if not playing or indicating the presence of the first type of disc; iii) if focus is not obtained changing the first set of player parameters to the second set of player parameters; iv) if focus is then found playing or indicating the presence of the second type of disc.

Abstract: Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Abstract: This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-C toxin.

Abstract: This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-C toxin.

Abstract: Articles are blow moulded from thermoplastic polymeric materials containing high proportions of fillers such as glass fibres. The method comprises extruding the filled polymeric material through a die having a mandrel for constraining the material into a tubular shape; coextruding between the die and the outer surface of the material, a liquid having a freezing temperature lower than that of the material; cooling the liquid and the outer surface of the material during their passage through the die to a temperature below the freezing temperature of the material but above the freezing temperature of the liquid while maintaining the inner surface of the material molten; squeezing the extrudate at suitable intervals to fuse the molten inner surface together and thereby seal discrete lengths; and inflating the sealed lengths to conform to a surrounding mould to produce laminar shapes which are then foamed-filled to give stiff panels.

Abstract: Articles are blow molded from thermoplastic polymeric materials containing high proportions of fillers such as glass fibres. The method comprises extruding the filled polymeric material through a die having a mandrel for constraining the material into a tubular shape, coextruding between the die and the outer surface of the material, a liquid having a freezing temperature lower than that of the material, cooling the liquid and the outer surface of the material during their passage through the die to a temperature below the freezing temperature of the material but above the freezing temperature of the liquid while maintaining the inner surface of the material molten, squeezing the extrudate at suitable intervals to fuse the molten inner surface together and thereby seal discrete lengths, and inflating the sealed lengths to conform to a surrounding mold to produce a shaped article. Lamina shapes may be foam-filled to give stiff panels.