Abstract: A technique for predictive modeling to generate ratings forecasts in a media network is described. An episode-level programming schedule is imported into a viewership forecasting application to generate episode-level ratings predictions. Episode-level ratings predictions for media content in the episode-level programming schedule are generated by implementing multiple different predictive algorithms in parallel for each instance of specific media content in the programming schedule. In addition, for each such predicted viewership value, an accuracy value is generated that indicates the likely accuracy of that predicted viewership value. The episode-level ratings predictions can be uploaded by a business unit of the media network, and merged with a programming schedule currently employed by the business unit.

Abstract: In one embodiment, a viewing behavior subsystem computes estimated viewership among target audiences at a person-level based on a household viewing logs and person-level data. A viewing behavior subsystem distributes the household viewing logs across buckets based on the sizes of the households and sets of person-level characteristics that are associated with the persons within the households. The viewing behavior subsystem generates a model for viewing behaviors associated with different sets of person-level characteristics based on the buckets. Subsequently, the viewing behavior subsystem estimates viewership among a target audience that is associated with one or more of the sets of person-level characteristics based on the model and census data.

Abstract: A technique for predictive modeling to generate ratings forecasts in a media network is described. An episode-level programming schedule is imported into a viewership forecasting application to generate episode-level ratings predictions. Episode-level ratings predictions for media content in the episode-level programming schedule are generated by implementing multiple different predictive algorithms in parallel for each instance of specific media content in the programming schedule. In addition, for each such predicted viewership value, an accuracy value is generated that indicates the likely accuracy of that predicted viewership value. The episode-level ratings predictions can be uploaded by a business unit of the media network, and merged with a programming schedule currently employed by the business unit.

Abstract: In one embodiment, a viewing behavior subsystem computes estimated viewership among target audiences at a person-level based on a household viewing logs and person-level data. A viewing behavior subsystem distributes the household viewing logs across buckets based on the sizes of the households and sets of person-level characteristics that are associated with the persons within the households. The viewing behavior subsystem generates a model for viewing behaviors associated with different sets of person-level characteristics based on the buckets. Subsequently, the viewing behavior subsystem estimates viewership among a target audience that is associated with one or more of the sets of person-level characteristics based on the model and census data.

Abstract: Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3–C6)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted ?-naphthyl, bicyclic heterocyclic aryl, (C3–C6)cycloalkyl-monocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof; and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.

Abstract: Compounds of formula (I) 1

Abstract: The present invention relates to the alpha-(N-substituted pyrrolidinyl and piperidinyl) alpha-(arysulfonamido)-aceto-hydroxamic acids of formula I ##STR1## wherein R represents acyl derived from a carboxylic acid, from a carbonic acid or from a carbamic acid; or R represents (lower alkyl, aryl-lower alkyl or aryl)-sulfonyl, di-(aryl-lower alkyl or alkyl)-aminosulfonyl, or aryl-lower alkyl; Ar represents carbocyclic aryl, heterocyclic aryl or biaryl; R.sub.1 and R.sub.2 represent independently hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, acyloxy, lower alkoxy-lower alkoxy, trifluoromethyl or cyano; or R.sub.1 and R.sub.

Abstract: Disclosed are compounds of formula I ##STR1## wherein R, R.sub.1, R.sub.2 and Ar have meanings as defined; pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and methods of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds.

Abstract: The invention relates to the compounds of formula I ##STR1## pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds.

Abstract: The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which comprises administering to a mammal in need thereof an effective macrophage metalloelastase inhibiting amount of a compound of formula I ##STR1## wherein Ar, R, R.sub.1 and R.sub.2 have meanings as defined, or of a pharmaceutically acceptable prodrug derivative thereof, or of a pharmaceutically acceptable salt thereof, or of pharmaceutical compositions comprising a said compound.

Abstract: Particularly the invention relates to the compounds of formula I ##STR1## (a) wherein Ar is carbocyclic or heterocyclic aryl;R is hydrogen, lower alkyl, carbocyclic aryl-lower alkyl, carbocyclic aryl, heterocyclic aryl, biaryl, biaryl-lower alkyl, heterocyclic aryl-lower alkyl, mono- or poly-halo-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, hydroxy-lower alkyl, acyloxy-lower alkyl, lower alkoxy-lower alkyl, lower alkyl-(thio, sulfinyl or sulfonyl)-lower alkyl, amino, mono- or di-lower alkylamino)-lower alkyl, acylamino-lower alkyl, (N-lower alkyl-piperazino or N-aryl-lower alkylpiperazino)-lower alkyl, or (morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl or N-lower alkylpiperidyl)-lower alkyl;R.sub.1 is hydrogen, lower alkyl, carbocyclic aryl-lower alkyl, carbocyclic aryl, heterocyclic aryl, biaryl, biaryl-lower alkyl, heterocyclic aryl-lower alkyl, mono- or poly-halo-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.3 -C.sub.