Patents by Inventor David T. Stitt
David T. Stitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7338778Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: October 4, 2004Date of Patent: March 4, 2008Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Jr., Patrick Shawn Beaty
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Patent number: 6900030Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: April 4, 2002Date of Patent: May 31, 2005Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Jr., Patrick Shawn Beaty
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Publication number: 20020155424Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: ApplicationFiled: April 4, 2002Publication date: October 24, 2002Inventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Patrick Shawn Beaty
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Patent number: 6395506Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: June 29, 1999Date of Patent: May 28, 2002Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Jr., Patrick Shawn Beaty
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Patent number: 5716798Abstract: This invention describes a method for the rapid identification of the presence of microorganisms in a sample. Briefly, in the method of this invention the sample container is divided into a plurality of discrete zones, each of which can be separately monitored for microbial presence. When a sample is placed into this container, detection is simplified as the volume monitored is low (as compared with the sample); since microbial detection is a concentration dependent phenomenon, the speed with which the presence of microbial contamination can be detected is increased.Type: GrantFiled: September 22, 1992Date of Patent: February 10, 1998Assignee: Becton Dickinson and CompanyInventors: James F. Monthony, David T. Stitt, Denise H. Burroughs
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Patent number: 5567598Abstract: This invention presents methods for detection and evaluation of metabolic activity of microorganisms based upon their ability to consume dissolved oxygen. The methods utilize a fluorescence detection system which makes use of the sensitivity of the fluorescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's fluorescent emission in a concentration dependent manner. Respiring microorganisms will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification and metabolic activity of microorganisms by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: March 3, 1993Date of Patent: October 22, 1996Assignee: Becton Dickinson and CompanyInventors: David T. Stitt, Gregory J. Burrell, Kwok-Yu Hu, James F. Monthony, Robert Sapitowicz
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Patent number: 5163441Abstract: A microbiological culture collection and transport device maintains viable organisms for periods of time longer than possible with existing sampling devices. It also allows recovery of detectable antigen at levels not achievable with conventional swabs. The new device has a sterile swabbing tip made with a non-toxic polyurethane foam having open cells at its exposed surface. It does not require a transport medium and can be used dry. The device may further include a sample inoculator to distribute organisms collected onto a solid or semi solid medium. Methods for collecting and transporting microbiological specimens and for recovering detectable antigen are also described.Type: GrantFiled: December 14, 1990Date of Patent: November 17, 1992Assignee: Becton, Dickinson and CompanyInventors: James F. Monthony, David T. Stitt, C. Michael Gosnell, Shannon D. Stewart
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Patent number: 5091316Abstract: A microbiological culture collection and transport device maintains viable organisms for periods of time longer than possible with existing sampling devices. It also allows recovery of detectable antigen at levels not achievable with conventional swabs. The new device has a sterile swabbing tip made with a non-toxic polyurethane foam having open cells at its exposed surface. It does not require a transport medium and can be used dry. The device may further include a sample inoculator to distribute organisms collected onto a solid or semi solid medium. Methods for collecting and transporting microbiological specimens and for recovering detectable antigen are also described.Type: GrantFiled: April 11, 1990Date of Patent: February 25, 1992Assignee: Becton, Dickinson and CompanyInventors: James F. Monthony, David T. Stitt, C. Michael Gosnell, Shannon D. Stewart