Abstract: The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of primary Sjögren's Syndrome. The present invention therefore provides methods of diagnosing and providing a prognosis for Sjögren's Syndrome, by examining relevant proteins (including certain autoantigens and autoantibodies) and RNA in a patient's saliva.

Abstract: The present invention provides for the first time the detection of micro-RNA in human saliva and the correlation between such micro-RNA and oral cancers. The present invention therefore provides methods and kits for diagnosing oral cancers by examining pertinent micro-RNA in saliva.

Abstract: The present invention provides for the first time molecular diagnostic and prognostic markers for tongue cancer metastasis and extracapsular spread that are independent of histopathological evaluation.

Abstract: A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.

Abstract: Methods of monitoring the expression of genes in malignant oral cells is disclosed. Gene expression profiles are used to identify markers associated with malignant oral cells and to diagnose oral cancer.

Abstract: A method of suppressing tumor cell growth, comprising administering to a mammal in need thereof an amount of an inhibitor of eosinophilia sufficient to result in suppression of tumor cell growth is disclosed.

Abstract: Disclosed is an isolated tumor suppressor protein inducible by tumor necrosis factor. Also disclosed are isolated cDNA molecules encoding the doc-1, a tumor suppressor protein, cells transformed with this cDNA, antibodies specific for and reactive with the doc-1 protein, and methods of using these proteins, cDNAs, and antibodies.

Abstract: The invention provides a method of enhancing wound healing, comprising administering an inhibitor of eosinophil influx into a wound site sufficient to result in healing of the wound.