Abstract: The present invention concerns the treatment of prostate cancer and particularly castration resistant prostate cancer (CRPC). The Heat Shock Protein Hsp27, a chaperone protein, has been long demonstrated as a driver of Castration Resistance Prostate Cancer (CRPC). In the light of identification of the molecular mechanisms, the inventor determined that the Probable ATP-dependent RNA helicase DDX5 is an interactor of Hsp27 and DDX5's expression is modulated by Hsp27. They confirmed that DDX5 overexpression is correlated to the aggressiveness of the tumor, to the CRPC emergency and to the biochemical recurrence risk. They also developed DDX5-targeting antisense oligonucleotides for research purpose and clinical application. Thus, the invention relates to an inhibitor of DDX5 wherein said inhibitor reduces the expression and/or activity of DDX5 in a subject in need thereof and targets the gene or the mRNA of DDX5.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to database driven collaborative applications and provide a novel and non-obvious method, system and computer program product for generating a separable query design object and database schema through visual view editing. In one embodiment, an application generation method can be provided. The method can include creating a form for a collaborative application, placing a data source user interface control within the form and binding at least one field of a database query result set to the data source user interface control. Finally, the method can include storing a database query for the result set separately from the form.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to plug-in deployment for component based applications in general and provide a method, system and computer program product for plug-in deployment in a clustered environment. In an embodiment of the invention, a method for plug-in deployment in a clustered environment can be provided. The method can include adding a plug-in for a component based application to a plug-in repository for the component based application. The component based application itself can execute in a node provided by a server in a clustered computing environment. The method further can include directing replication of the added plug-in in the node to other plug-in repositories in other nodes provided by other servers in the clustered computing environment.

Abstract: Systems, methods and computer program products for automating packaging and provisioning of J2EE Web Modules to Eclipse-based Rich Clients.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to mnemonic labels and provide a method, system and computer program product for multi-lingual dynamic assignment and management of user interface label mnemonics. In one embodiment of the invention, a dynamic label mnemonic assignment method can be provided. The method can include generating a run-time set of label mnemonics for a set of labels in a user interface for a computer program, determining if any of the run-time generated label mnemonics are not unique for the set of label mnemonics, and responsive to determining that any of the run-time generated label mnemonics are not unique for the set of label mnemonics, generating a different set of label mnemonics for the set of labels.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to database driven collaborative applications and provide a novel and non-obvious method, system and computer program product for generating a separable query design object and database schema through visual view editing. In one embodiment, an application generation method can be provided. The method can include creating a form for a collaborative application, placing a data source user interface control within the form and binding at least one field of a database query result set to the data source user interface control. Finally, the method can include storing a database query for the result set separately from the form.

Abstract: A system and method of highlighting and manipulating text of different languages or fonts which are matched to a best-matching font are presented. Today's operating systems do not provide the native tools and functions to easily display text of unknown language or multiple languages. The complexity of any underlying code that handles a multilingual display is sharply increased due to the text being segmented into multiple text runs. The invention employs character set engine that provides necessary character set guessing functionality, as well as an enumerator module to build a linked list of suitable output fonts to display text from an arbitrary language, and multilingual text. Output can be granted by traversing that list. Different portions of the sequence of languages in the text may have minimum outline, start and end markers and other highlighting and other text manipulation features scaled or adjusted according to the differing fonts.