Patents by Inventor David Taussig

David Taussig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR SEQUENCING POLYNUCLEOTIDE FRAGMENTS FROM BOTH ENDS
    Publication number: 20240018510
    Abstract: The present invention relates to preparation, sequencing and analysis of a sequencing library of adaptor-tagged fragments, wherein the fragments have different orientations relative to a sequencing adaptor.
    Type: Application
    Filed: December 10, 2020
    Publication date: January 18, 2024
    Inventors: David Taussig, Israel Steinfeld, Nicholas M Sampas, Brian Jon Peter
  • ASSEMBLY OF LONG NUCLEIC ACIDS BY LIGATION USING INDEXED SPLINT OLIGOS
    Publication number: 20230037679
    Abstract: The present disclosure relates to a method of assembling long nucleic acids by enzymatically ligating oligonucleotide molecules hybridized to an indexed splint oligonucleotide molecules. Also disclosed are oligonucleotide structures comprising an indexed splint oligonucleotide useful in performing the disclosed method.
    Type: Application
    Filed: August 2, 2022
    Publication date: February 9, 2023
    Inventors: David TAUSSIG, Nicholas M. SAMPAS
  • LIGATION-BASED GENE EDITING USING CRISPR NICKASE
    Publication number: 20230008217
    Abstract: Disclosed are compositions and methods for gene editing. The present disclosure relates to compositions and methods for gene editing using a Cas nickase to cleave a double-stranded nucleic acid sequence near a target site and a ligase to incorporate a nucleic acid into a double-stranded nucleic acid sequence. The present disclosure also provides reagents for use in the gene editing methods. The present disclosure further provides kits containing reagents for use in the gene editing methods.
    Type: Application
    Filed: December 17, 2020
    Publication date: January 12, 2023
    Inventors: Nicholas M. SAMPAS, David TAUSSIG
  • Method for making an asymmetrically-tagged sequencing library
    Patent number: 10711269
    Abstract: A method for making an asymmetrically-tagged sequencing library is provided. In some embodiments, the method may comprise: obtaining a symmetrically-tagged library of cDNA or genomic DNA fragments, hybridizing a tailed first primer to the 3? sequence tag of the library and extending the same to produce primer extension products, and amplifying the primer extension products using a pair of tailed primers to produce asymmetrically-tagged library.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: July 14, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Brian Jon Peter, David Taussig, Bahram Arezi, Robert A. Ach, Nicholas M. Sampas
  • METHOD FOR MAKING AN ASYMMETRICALLY-TAGGED SEQUENCING LIBRARY
    Publication number: 20180201924
    Abstract: A method for making an asymmetrically-tagged sequencing library is provided. In some embodiments, the method may comprise: obtaining a symmetrically-tagged library of cDNA or genomic DNA fragments, hybridizing a tailed first primer to the 3? sequence tag of the library and extending the same to produce primer extension products, and amplifying the primer extension products using a prior of tailed primers to produce asymmetrically-tagged library.
    Type: Application
    Filed: January 18, 2017
    Publication date: July 19, 2018
    Inventors: Brian Jon Peter, David Taussig, Bahram Arezi, Robert A. Ach, Nicholas M. Sampas