Patents by Inventor David Tew

David Tew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PROCESSES FOR THE PRODUCTION OF POLYNUCLEOTIDES INCLUDING OLIGONUCLEOTIDES
    Publication number: 20250223620
    Abstract: The invention relates to novel processes using enzymes for the production of polynucleotides or oligonucleotides, wherein said processes are suitable for use in the production of modified polynucleotides or oligonucleotides, such as those for use in therapy.
    Type: Application
    Filed: April 6, 2023
    Publication date: July 10, 2025
    Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Andreas CRAMERI, Douglas FUERST, Joseph HOSFORD, David TEW
  • Thermoelectric device based refrigerant subcooling
    Publication number: 20090266084
    Abstract: A subcooler (15) for a vapor compression cycle having a refrigerant. The subcooler (15) including a conduit (45) and one or more thermoelectric modules (17). The conduit (45) being in fluid communication with the vapor compression cycle for flow of the refrigerant therethrough. Each of the one or more thermoelectric modules (17) has a cold side in thermal communication with an inner volume of the conduit (45) for subcooling the refrigerant.
    Type: Application
    Filed: August 29, 2005
    Publication date: October 29, 2009
    Inventors: Rakesh Radhakrishnan, Xiaomei Yu, Gregory M. Dobbs, David Tew, Michael K. Sahm, Chung-Yi Tsai
  • Method of site specific labeling of proteins and uses therefor
    Publication number: 20070190578
    Abstract: Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.
    Type: Application
    Filed: September 16, 2005
    Publication date: August 16, 2007
    Inventors: Wenfang Chen, Thomas Meek, David Powell, David Tew
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20070077251
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds.
    Type: Application
    Filed: November 22, 2006
    Publication date: April 5, 2007
    Inventors: Colin MacPhee, David Tew
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20060040371
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: May 31, 2005
    Publication date: February 23, 2006
    Inventors: Colin MacPhee, David Tew, Donald Southan, Deirdre Mary Hickey, Israel Gloger, Geoffrey Lawrence, Simon John Rice
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20050260731
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: April 18, 2005
    Publication date: November 24, 2005
    Inventors: Colin MacPhee, David Tew, Christopher Southan, Deirdre Mary Hickey, Israel Gloger, Geoffrey Mark Lawrence, Simon Rice
  • Method of site specific labeling of proteins and uses therefor
    Publication number: 20050136491
    Abstract: Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.
    Type: Application
    Filed: December 15, 2004
    Publication date: June 23, 2005
    Inventors: Wenfang Chen, Thomas Meek, David Powell, David Tew
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20050106611
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compunds to identify those compounds.
    Type: Application
    Filed: October 26, 2004
    Publication date: May 19, 2005
    Inventors: Colin MacPhee, David Tew