Patents by Inventor David Thomas Manallack

David Thomas Manallack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydronapthalene derivatives and their therapeutic use
    Patent number: 6133240
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a fucose or mannose residue, have therapeutic utility via inhibition of selectins, and thus of cell adhesion.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 17, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventors: Richard John Kenneth Taylor, Paul Vincent Murphy, John Gary Montana, David Thomas Manallack
  • Quinolones and their therapeutic use
    Patent number: 5891878
    Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumour Necrosis Factor activity. The compounds of the invention have the general formula (I): ##STR1## The compounds of the invention encompassed by formula (I) include enantiomers, diastereoisomers and mixtures, including racemic mixtures.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: April 6, 1999
    Assignee: Chiroscience Limited
    Inventors: Steven Colin Beasley, John Gary Montana, Hazel John Dyke, Alan Findlay Haughan, Karen Ann Runcie, David Thomas Manallack, George Martin Buckley, Robert James Maxey, Hannah Jayne Kendall, Andrew Douglas Baxter
  • Purine and guanine derivatives
    Patent number: 5863921
    Abstract: Compounds of formula (I) ##STR1## wherein n=1 or 2;R.sup.1 is H, NH.sub.2 or halogen;R.sup.2 is H or NH.sub.2 ;R.sup.3 represents the group ##STR2## where m=0 or 1; R.sup.4 and R.sup.5 are the same or different and are each H, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3, tetrazole, (CR.sup.6 R.sup.7).sub.p (Y).sub.q (CR.sup.6 R.sup.7).sub.t Z where (CR.sup.6 R.sup.7)p or (CR.sup.6 R.sup.7).sub.t may be straight or branched chain bearing the substituents R.sup.6 and R.sup.7 when p and t>1; R.sup.6 and R.sup.7 are the same or different and are each C.sub.0-6 alkyl-Z;p=1-3;q=0 or 1;t=0-4, provided that t>0 wgeb q=1;Y is NH, O, S(O)u where u=0-2;Z is H, CN, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3, tetrazole, triazole, CONH.sub.2, CON(C.sub.1-6 alkyl).sub.2, CONH(C.sub.1-6 alkyl), SO.sub.2 NH (C.sub.1-6 alkyl) or SO.sub.2 N(C.sub.1-6 alkyl).sub.2 ; or a salt, soluate or hydrate thereof.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: January 26, 1999
    Assignee: Darwin Discovery Limited
    Inventors: Steven Colin Beasley, John Gary Montana, David Thomas Manallack