Abstract: An actuator arrangement includes an actuator screwshaft configured to receive a female connector, a lockpin having a male connector that is connected to the female connector. When the actuator screwshaft is rotated, in use, the lockpin is configured to move from a first position to a second position.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating user interfaces and alerts for applications running on software platforms using indicator files. A method includes obtaining, by a software platform system configured to host computing tasks in a cloud computing environment of the distributed computing system, a user-customizable indicator file that specifies a set of indicators and, for at least one of the indicators, one or more alert thresholds. Each indicator is a measurable parameter for a particular computing task hosted by the software platform system. A monitoring service uses the user-customizable indicator file to obtain one or more values for each of one or more of the indicators from the software platform system. The monitoring service uses the user-customizable indicator file to generate a graphical user interface that includes, for each indicator, data specifying the one or more values for the indicator.

Abstract: A mill liner element is structured with an elongated elastomer member having a non-elastomeric backing plate and a plurality of non-elastomeric inserts formed into the elastomer member to provide a liner element that provides a lifter bar element and a wear element that is less prone to cracking compared to conventional all-metal mill lining elements, and which provides ease of handling and replacement when worn. A multiplicity of mill liner elements are positionable in a grinding mill shell, and are suitable for use in a variety of types of grinding mill structures, including ball mills and AG and SAG mills.

Abstract: An actuator comprises a screw shaft, a nut translatable along the shaft between a retracted position and an extended position, a tine component carried by the nut, the tine component including tine fingers formed with projections each being engageable with a formation provided on a housing when the nut occupies its extended position to secure the nut against axial movement, and a lock member engageable with the tine fingers to restrict radial movement of the tine fingers.

Abstract: A mill liner element is structured with an elongated elastomer member having a non-elastomeric backing plate and a plurality of non-elastomeric inserts formed into the elastomer member to provide a liner element that provides a lifter bar element and a wear element that is less prone to cracking compared to conventional all-metal mill lining elements, and which provides ease of handling and replacement when worn. A multiplicity of mill liner elements are positionable in a grinding mill shell, and are suitable for use in a variety of types of grinding mill structures, including ball mills and AG and SAG mills.

Abstract: An operating system kernel includes an attach mechanism and a detach mechanism. In addition, processes are tagged with an access attribute identifying the process as either a client process or a server process. Based on the access attribute, the operating system kernel lays out the process local address space differently depending on whether the process is a client process or a server process. A server process can “attach” to a client process and reference all of the client process' local storage as though it were its own. The server process continues to reference its own process local storage, but in addition, it can reference the other storage, using the client process' local addresses. When access to the other storage is no longer needed, the server process can “detach” from the client process. Once detached, the other storage can no longer be referenced.

Abstract: Compounds of Formula (1) and their pharmaceutically acceptable salts are described: Formula (1) Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

Abstract: An actuator comprises a screw shaft, a nut translatable along the shaft between a retracted position and an extended position, a tine component carried by the nut, the tine component including tine fingers formed with projections each being engageable with a formation provided on a housing when the nut occupies its extended position to secure the nut against axial movement, and a lock member engageable with the tine fingers to restrict radial movement of the tine fingers.

Abstract: Compounds of Formula (1) and their pharmaceutically acceptable salts are described: Formula (1) Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

Abstract: An apparatus and method provide simultaneous local and global addressing capabilities. A global address space is defined that may be accessed by all processes. In addition, each process has a local address space that is local (and therefore available) only to that process. An address translation mechanism is implemented, preferably in hardware, to compare an address to defined addresses for local and global addressing and to detect when a virtual address computation result would go outside a boundary for the appropriate addressing scheme. The address translation mechanism maps a virtual address to a corresponding physical address, and uses different criteria depending on whether the address is local or global.

Abstract: An apparatus and method provide simultaneous local and global addressing capabilities. A global address space is defined that may be accessed by all processes. In addition, each process has a local address space that is local (and therefore available) only to that process. An address translation mechanism is implemented, preferably in hardware, to compare an address to defined addresses for local and global addressing and to detect when a virtual address computation result would go outside a boundary for the appropriate addressing scheme. The address translation mechanism maps a virtual address to a corresponding physical address, and uses different criteria depending on whether the address is local or global.

Abstract: The present invention provides a conjugate of a solution stable G-CSF derivative and a water soluble polymer which is an acid stable physiologically active substance derived from naturally occurring G-CSF.

Abstract: Ribotoxins, such as restrictocin, mitogillin and alpha-sarcin which do not contain a cysteine for linkage to antibodies for immunotoxin production need to be modified for such linkage without compromising biological activity. Protein analogues of such native ribotoxins are provided in which both the analogue and the native ribotoxin can cleave only a single phosphodiester bond of 28S rRNA in a 60S ribosomal subunit and in which the analogue comprises only one cysteine available from covalent linkage to a partner, such as an antibody, which cysteine is not present in the native ribotoxin. Especially preferred analogues are restrictocin Cys 13, Cys 82, Cys 106 and Cys 110 and restrictocin Cys 150-Gly151. Corresponding DNA sequences, vectors, host cells, immunotoxins and pharmaceutical compositions are also claimed.

Abstract: Derivatives of naturally occurring G-CSF having at least one of the biological properties of naturally occurring G-CSF, and a solution stability of at least 35% at 5 mg/ml are disclosed in which the derivative has at least Cys.sup.17 of the native sequence replaced by a Ser.sup.17 residue and Asp.sup.27 of the native sequence replaced by a Ser.sup.17 residue. Nucleotide sequences coding for part or all of the amino acid sequence of the derivatives of the invention may be incorporated into autonomously replicating plasmid or viral vectors employed to transform or transfect suitable procaryotic or eucaryotic host cells such as bacteria, yeast or vertebrate cells in culture.

Abstract: Pharmaceutical compositions for continuous release of a physiologically active substance in which the physiologically active substance comprises a polypeptide covalently conjugated to a water soluble polymer show particularly desirable release characteristics. Polypeptides for use in the pharmaceutical compositions include G-CSF and solution stable derivatives thereof, human calcitonin and interleukin-2. The material of the composition may be a polylactide or biodegradable hydrogel derived from an amphipathic block copolymer.The compositions enable a therapeutically effective polypeptide to be continuously released over a prolonged period of time following a single administration of the pharmaceutical composition to a patient.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 stands for an alk-2-enyl radical of not more than 5 carbon atoms or a furylmethyl radical, R.sup.2 stands for an alk-2-enyl or alkyl radical of not more than 5 carbon atoms or a furylmethyl radical, >N--A, B, D, E and F stand for defined amino acid or aza-amino-acid residues, and in particular one or both of B and D stand(s) for an amino acid residue of the formula --NH.C(1-3C alkyl)(1-3C alkyl).CO-- or a similar residue, and X stands for --OR.sup.7 or --NR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8, which may be the same or different, stand for hydrogen or a (1-4C)alkyl radical, and wherein the linkages are all conventional peptide linkages or in the case of D-E the peptide linkage is replaced by the group --CH.sub.2 S--, and pharmaceutically-acceptable salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutically-acceptable diluent or carrier.