Patents by Inventor David Timothy MacPherson

David Timothy MacPherson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS
    Publication number: 20130317041
    Abstract: The present invention relates to benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the preparation of medicaments suitable for the treatment of gastrointestinal disorders.
    Type: Application
    Filed: August 5, 2013
    Publication date: November 28, 2013
    Applicant: Glaxo Group Limited
    Inventors: Christopher Norbert JOHNSON, David Timothy MacPherson, Steven James Stanway, Geoffrey Stemp, Mervin Thompson, Susan Marie Westaway
  • Benzylpiperazine derivatives and their medical use
    Patent number: 8536182
    Abstract: The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: September 17, 2013
    Assignee: Glaxo Group Limited
    Inventors: Christopher Norbert Johnson, David Timothy Macpherson, Steven James Stanway, Geoffrey Stemp, Mervyn Thompson, Susan Marie Westaway
  • Indazoles used to treat estrogen receptor beta mediated disorders
    Patent number: 7960563
    Abstract: The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: June 14, 2011
    Assignee: Glaxo Group Limited
    Inventors: Christopher Norbert Johnson, David G Jones, Xi Liang, David Timothy MacPherson, Aaron B Miller, Antoinette Naylor, Steven James Stanway, Andrew Kenneth Takle, Giancarlo Trani
  • Compounds
    Patent number: 7956083
    Abstract: The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: June 7, 2011
    Assignee: Glaxo Group Limited
    Inventors: Christopher Norbert Johnson, David G. Jones, Xi Liang, David Timothy MacPherson, Aaron B Miller, Steven James Stanway, Andrew Kenneth Takle, Giancarlo Trani, Antoinette Wilson
  • COMPOUNDS
    Publication number: 20100324106
    Abstract: The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
    Type: Application
    Filed: February 17, 2009
    Publication date: December 23, 2010
    Inventors: Christopher Norbert Johnson, David G. Jones, Xi Liang, David Timothy Macpherson, Aaron B. Miller, Steven James Stanway, Andrew Kenneth Takle, Giancarlo Trani, Antoinette Wilson
  • Indazoles Used To Treat Estrogen Receptor Beta Mediated Disorders
    Publication number: 20100087502
    Abstract: The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
    Type: Application
    Filed: March 5, 2008
    Publication date: April 8, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Christopher Norbert Johnson, David G. Jones, Xi Liang, David Timothy Macpherson, Aaron B. Miller, Antoinette Naylor, Steven James Stanway, Andrew Kenneth Takle, Giancarlo Trani
  • BENZYLPIPERAZINE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090054456
    Abstract: The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
    Type: Application
    Filed: July 24, 2006
    Publication date: February 26, 2009
    Inventors: Christopher Norbert Johnson, David Timothy Macpherson, Steven James Stanway, Geoffrey Stemp, Mervyn Thompson, Susan Marie Westaway
  • Hydroxyethylamine derivatives for the treatment of Alzheimer's disease
    Patent number: 7253198
    Abstract: The present invention relates to novel hydroxyethylamine compounds having Asp2 (?-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: August 7, 2007
    Assignee: Glaxo Group Limited
    Inventors: Emmanuel H Demont, Andrew Faller, David Timothy MacPherson, Peter Henry Milner, Alan Naylor, Sally Redshaw, Steven James Stanway, David R Vesey, Daryl S Walter
  • Benzamide derivatives, processes for their preparation, and their pharmaceutical use
    Patent number: 6992103
    Abstract: The present invention relates to novel hydroxyethylene compounds having Asp2 (?-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: January 31, 2006
    Assignee: SmithKline Beecham P.L.C.
    Inventors: Andrew Faller, David Timothy MacPherson, Peter Henry Milner, Steven James Stanway, Leontine Saskia Trouw
  • Novel compounds
    Publication number: 20040209822
    Abstract: Compounds of the formula (I): 1
    Type: Application
    Filed: May 13, 2004
    Publication date: October 21, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Andrew Faller, Anne-Geraldine Rousseau, David Timothy MacPherson, Peter Henry Milner
  • 2,'3-Amino-4-(n-hydroxyamino)-succinylamino-acetamides for use as cd23 formation inhibitors
    Publication number: 20030207923
    Abstract: Compounds of formula (I): wherein X1 is alkyl, sulphonyl or carboxy: X2 is hydrogen or alkyl; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated by s-CD23.
    Type: Application
    Filed: May 14, 2003
    Publication date: November 6, 2003
    Inventors: Andrew Faller, Anne-Geraldine Rousseau, David Timothy Macpherson, Peter Henry Milner
  • Hydroxamic acid derivatives as inhibitors of the production of human CD23 and of the TNF release
    Patent number: 6458779
    Abstract: Compounds of Formula (1) wherein: R is methyl substituted by one to three groups from alkyl, aryl, alkenyl, and alkynyl; n is ) or 1; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated y s-CD23.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Andrew Faller, David Timothy MacPherson, Peter Henry Milner, Jayshree Mistry, John Gerald Ward
  • Phenyl derivatives useful as endothelin receptor antagonists
    Patent number: 6147111
    Abstract: Novel phenyl derivatives which are useful as endothelin receptor antagonists.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: November 14, 2000
    Assignees: SmithKline Beecham p.l.c., SmithKline Beecham Corporation
    Inventors: Jia-Ning Xiang, David Timothy MacPherson, David Francis Corbett, John Duncan Elliott