Abstract: A flap (20) for an inhalation actuated mechanism (18) of a powder inhaler (1) comprises a base member (29), a skirt structure (24) projecting from a surface of the base member (29), and a coupling portion (21) to be coupled to a resilient member (40?) of the inhalation actuated mechanism (18).

Abstract: Catalyst systems contain metal-ligand complexes according to formula (I): In formula (I), M is Ti, Zr, of Hf; n is 0, 1, 2, or 3; m is 1 or 2; each R1 and each R2 is independently chosen from (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, (C1-C40)aryl, (C1-C40)heteroaryl, halogen, and —H; R1 and R2 are optionally covalently linked to each other; and each R3 is a hydrocarbon or heterohydrocarbon radical having an identity depending on the value of subscript m. The metal-ligand complexes may be incorporated as procatalysts in catalyst systems for polyolefin polymerization.

Abstract: An automotive electrical system provides power from two DC sources each connected to a separate group of integrity-protected (ASIL) loads. A third group of non-ASIL loads are connected to both power sources through a controllable isolator with first and second transistor arrays. The connection through the isolator also connects each ASIL group to the other DC source. A control circuit includes a plurality of drivers for driving the first and second transistor arrays into conduction. The control circuit is configured to cease driving at least a respective one of the first and second transistor arrays when a fault condition is detected in which current flow in at least one of the transistor arrays exceeds a threshold.

Abstract: Techniques for intelligent messaging for message syncing are described. An apparatus may comprise a recipient inbound messaging component, a recipient queue management component, a recipient update customization component, and a recipient outbound messaging component. The recipient inbound messaging component may be operative to receive an incoming update at a recipient update queue, the recipient update queue associated with a recipient of the incoming update. The recipient queue management component may be operative to add the incoming update to the recipient update queue and determine a recipient messaging endpoint to receive the incoming update. The recipient update customization component may be operative to retrieve one or more recipient messaging endpoint parameters associated with the recipient messaging endpoint and generate a customized incoming update from the incoming update according to the one or more recipient messaging endpoint parameters.

Abstract: In one embodiment, a flow cytometer is disclosed having a compact light detection module. The compact light detection module includes an image array with a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side. Each of the plurality of filters reflects light to one of the plurality of micro-mirrors and passes light of a differing wavelength range and each of the plurality of micro-mirrors reflects light to one of the plurality of filters, such that incident light into the image array zigzags back and forth between consecutive filters of the plurality of filters and consecutive micro-mirrors of the plurality of micro-mirrors. A radius of curvature of each of the plurality of micro-mirrors images the fiber aperture onto the odd filters and collimates the light beam on the even filters.

Abstract: Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm's canal. Methods may include implanting a support within Schlemm's canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.

Abstract: A method is provided for measuring time varying particle fluxes with improved temporal resolution and signal to noise ratio. The particles can be photons, neutrons, electrons or electrically charged particles. The method includes a set of electronic and/or optical components and a set of algorithms that implement N-fold temporal multiplexing of the input flux. The system can be used to measure other types of flux by using a transducer to convert the flux into a compatible form. The system can include a transducer such as a scintillator that operates to convert particle flux incident into a photon flux proportional to the amplitude of particle flux. The invention can be used with multiplexing methods known to those skilled in the art, for example Hadamard and Fourier methods.

Abstract: Components of a system for generating anonymized data from timestamped event data are disclosed. The generation of anonymized data is performed in accordance with an anonymization configuration. The anonymization configuration includes information regarding the source of the event data, particulars about the anonymization process that transforms the clear event data from the source into an anonymized form, and particulars about the destination and characteristics for the output dataset. A graphical user interface permits development of anonymization configurations in an interactive, iterative way. The configured anonymizer employs methods and options to produce anonymized data with superior usability as a substitute for real world data, including a mode to effectively emulate live data streams.

Abstract: Improvements to network switches and other network components that enable improved status monitoring and logging of network and device parameters, particularly for networked video surveillance applications. The network switch or other network component, which may be an IP camera for example, outputs a networked video stream which contains graphical representations of relevant data, such as simple graphs or indicators. The networked video stream, and therefore the relevant data, can then be conveniently viewed and/or stored as a networked video stream with existing standard technology. An additional benefit is that conventional motion detection can be performed on the graphical representations in the networked video stream to generate alarms or trigger events.

Abstract: An online agricultural system manages and optimizes interactions of entities within the system to enable the execution of transaction and the transportation of crop products. The online agricultural system accesses historic and environmental data describing factors that may impact crop product transactions and/or transportation to determine market prices for crop products and crop product transportation. Responsive to receiving a request from an entity, the online agricultural system determines an optimal transaction for the entity, such as a price for selling a crop product, an available crop product for purchase, or a transportation opportunity to transport a crop product.

Abstract: A method for assisting a driver of a host vehicle in avoiding a collision, the method including: detecting a target in the vicinity of the vehicle; determining that the host vehicle is travelling on a collision course with the target; detecting a set of road markers on a side of the target; detecting a free space on the side of the road markers opposite the target side of the road markers, and when a collision with the target is predicted to occur within a predetermined time period and no driver initiated steering action for avoiding the collision course has been detected, providing a steering guidance to the driver of the host vehicle including altering of a steering wheel angular orientation for momentarily steering the host vehicle towards the road markers to indicate an evasive steering action to the driver.

Abstract: A press guiding device for a baler includes at least one continuous pressing device, at least two pressing segments, and at least one guiding device arranged at least partially between the pressing segments. The at least one guiding device is supported in a rotationally secure manner at or on a common axle with a roller.

Abstract: While a first wearable audio output component of a wearable audio output device is in a first position relative to a first ear of a user and a second wearable audio output component of the wearable audio output device is in the first position relative to a second ear, a computer system operates the wearable audio output device in a first mode. While doing so, the computer system detects a change in position of the first component from the first position to a second position; and, in response, while the second component is maintained in the first position, the computer system transitions the wearable audio output device from the first mode to a different, second mode that is a pass-through mode in which audio outputs provided via the wearable audio output device include pass-through audio components that include at least a portion of ambient sound from the physical environment.

Abstract: A tuner includes a housing including an upper housing part and a lower housing part, a printed circuit board arranged in the housing, and an electronics component arranged on the printed circuit board. A region of at least one of the upper housing part and the lower housing part is a heat-conductive material and the electronics component is connected to the region in a heat-transmitting manner.

Abstract: An ultrasonic cutting tip has a hollow shaft with a proximal and distal end. The proximal end is configured to be attached to an ultrasonic hand piece, and the distal end has a smooth continuous surface. An opening is located near the distal end of the hollow shaft. The opening is configured to cut vitreous when the cutting tip is vibrated ultrasonically in a torsional manner.

Abstract: A method for determining gaze calibration parameters for gaze estimation of a viewer using an eye-tracking system. The method comprises obtaining a set of data points including gaze tracking data of the viewer and position information of at least one target visual; selecting a first subset of the data points and determining gaze calibration parameters using said first subset. A score for the gaze calibration parameters is determined by using the gaze calibration parameters with a second subset of data points, wherein at least one data point of the subset is not included in the first subset. The score is indicative of the capability of the gaze calibration parameters to reflect position information of the at least one target visual based on the gaze tracking data. The score is compared to a candidate score and if it is higher, the calibration parameters are set to the candidate calibration parameters and the score to the candidate score.

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally comprise a therapeutic amount of a first saccharide and a therapeutic amount of a second saccharide or an organic acid. The saccharides may be, for example, a pentose, a disaccharide, a cyclodextrin, a pectic substance or a non-digestible polysaccharide. The organic acid may be, for example, malic acid.

Abstract: The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.