Abstract: A drill bit and method for normalizing bone is provided. The drill bit has a non-round drill bit core that is adapted to cut hard bone and to not cut soft bone. The drill bit has a cutting edge which may be positioned within a compression zone of the non-round drill bit core. The rotational speed of the drill bit and the profile of the drill bit core are tuned so that hard bone recovers into a cutting zone defined by the cutting edge while soft bone remains outside of the cutting zone. The insertion torque of the drill bit can be measured to determine when the normalization is adequate.

Abstract: A balloon guiding sheath may include an elongated sheath comprising a proximal end, a distal end, an inner tube, an outer tube surrounding the inner tube, an access port located adjacent the proximal end, a distal port located adjacent the distal end, and a working lumen extending between the access port and the distal port. The balloon guiding sheath may also include an inflatable balloon located on an outer surface of the elongated sheath adjacent the distal end. The balloon guiding sheath may also include a textured surface located along an outer portion of the outer tube and located beneath the inflatable balloon. The elongated sheath may be sized and configured to enable direct insertion into vasculature of a patient through an arteriotomy in at least one of a carotid artery or a vertebral artery to position the inflatable balloon at a target site.

Abstract: The present disclosure relates to the field of pharmaceutical compounds and preparations and method of their use in the treatment of disease. Described are antisense oligonucleotide (ASO) molecules, compositions containing the same, and uses thereof for treating or preventing coronavirus infections. In particular, the present disclosure provides specific ASOs that are effective against a broad spectrum of coronaviruses, and especially the ?-coronaviruses, including SARS-CoV-2, the causative agent of COVID-19.

Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: A syringe assembly (10, 80, 132, 192) includes a syringe barrel (12, 86, 134, 194) having a proximal end and a distal end, a needle (18, 89, 140, 200) coupled to the distal end of the syringe barrel, a body (22, 142, 202) coupled to the syringe barrel, and movable shield (24, 82, 164, 222) for moving in an axial direction between a first position where the needle is exposed and a second position covering at least a portion of the needle. The body (22, 142, 202) is configured for enabling the shield (24, 82, 164, 222) to move to the second position and retain the shield in the second position. The shield (24, 82, 164, 222) can slide axially, and rotate relative to the body or slide transversely relative to the body when the shield is in the second position.

Abstract: A pump system for pumping production fluids from a wellbore or pumping well treatment fluids into a wellbore comprising: an axial flux electric motor; a seal section coupled to the axial flux motor; a pump intake coupled to the seal section; a pump coupled to the pump intake, and a fluid discharge coupled to the pump. The torque capacity axial flux motor may be modified without removing the axial flux motor from the pump.

Abstract: A pump system for pumping production fluids from a wellbore or pumping well treatment fluids into a wellbore comprising: an axial flux electric motor; a seal section coupled to the axial flux motor; a pump intake coupled to the seal section; a pump coupled to the pump intake, and a fluid discharge coupled to the pump. The torque capacity axial flux motor may be modified without removing the axial flux motor from the pump.

Abstract: A computer-implemented method, a computer program product, and a computer system for determining skill adjacencies using a machine learning model. A computer calculates first similarity scores between first skill vectors obtained from one or more training datasets and second similarity scores between the first skill vectors and skill category vectors pre-calculated from job requisitions, using both a reference corpus word embedding model and a target corpus word embedding model. The computer generates features extracted from the first similarity scores and the second similarity scores. Based on the features, the computer trains a machine learning model for classifying combinations of skills as adjacent and non-adjacent. The machine learning model is used to determine skill adjacencies between skills extracted from the job requisitions and skills extracted from resumes.

Abstract: A system for a drug delivery device is provided. The system includes: a housing and a cartridge unit that is attachable to the housing or releasably attached to the housing. The cartridge unit includes a cartridge unit guide feature, the cartridge unit guide feature being provided to establish a guiding interface with the housing in order to guide relative movement of the cartridge unit and the housing with respect to one another when attaching the cartridge unit to the housing. The cartridge unit includes a cartridge unit interface feature, the cartridge unit interface feature being provided to form a further interface, in addition to the guiding interface, with the housing of the further interface being established when the cartridge unit is attached to the housing.

Abstract: A structural support casing for fan blade containment in a gas turbine engine includes at least one region in which two or more sub-laminates of fibre-reinforced composite material are spaced apart from one another by ductile polymeric material.

Abstract: In various embodiments, the gaming system and method provide The present disclosure relates generally to gaming systems and methods that concurrently display one or more aspects of a primary game and a play of a secondary game within the limited display space available of an electronic gaming machine with a single display device.

Abstract: An implement has an implement frame and a wheel for supporting the implement frame on a ground surface for movement in a direction of travel. The implement also includes a first basket coupled to the implement frame by a first arm and configured to work a portion of the ground surface, and a second basket coupled to the implement frame by a second arm and positioned rearward of the first basket relative to the direction of travel. The second basket is configured to work the portion of the ground surface after the first basket. A hydraulic cylinder is operatively coupled to the first arm and/or the second arm and configured to lift and lower the respective basket with respect to the ground surface to and from a raised position for travel. The hydraulic cylinder is further configured to regulate a pressure of the respective basket against the portion of the ground surface.

Abstract: One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a clutch interposed between the motor and an output shaft of the internal-combustion engine; an engine shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the engine shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed.

Abstract: Disclosed are embodiments of synthetic garnet materials for use in radiofrequency applications. In some embodiments, increased amounts of bismuth can be added into specific sites in the crystal structure of the synthetic garnet in order to boost certain properties, such as the dielectric constant and magnetization. Accordingly, embodiments of the disclosed materials can be used in high frequency applications, such as in base station antennas.

Abstract: An apparatus for cooling one or more heat generating components comprises: a sealable enclosure defining a volume for containing a first coolant and one or more heat generating components; a conduit surrounded by the volume, the conduit enabling a second coolant to enter and leave the enclosure, the conduit providing a fluid-tight seal between the first coolant and the second coolant when the first coolant within the volume surrounds the conduit; and a pump within the enclosure configured to direct the first coolant to the conduit such that heat is exchanged between the first coolant and the second coolant.

Abstract: A method of creating a shunt between a right atrium and a left atrium of a mammalian heart including puncturing an atrial septum between the right atrium and the left atrium to create a shunt. An ablation device having balloon is advanced at least partially through the shunt. The balloon is inflated and configured to thermally isolate the atrial septum from blood within the left atrium and the right atrium. Ablation energy is delivered to ablate the atrial septum.

Abstract: Disclosed is a treatment reactor for treating a continuously flowing liquid, comprising: an inlet for receiving liquid to be treated; and an outlet for outputting the treated liquid, whereby the liquid flows from the inlet to the outlet, wherein the reactor comprises an electrolysis unit arranged to subject the flowing liquid to electrolysis, and a microwave unit arranged to subject the flowing liquid to a microwave field.

Abstract: Provided herein are 1,2,3-triazole derivatives and methods of use thereof.

Abstract: Systems and methods for adaptive recursive descent data redundancy are described herein. In one embodiment, a method can include identifying the data object or file for Quantum Fragmentation, determining, via a first portion of a Quantum Fragmentation instance, a factor of fragmentation for the data object or file, transforming the data object or file into a plurality of first data fragments according to the factor of fragmentation by applying one or more cryptographic processing, integrity checking, and resilient fragmentation schemes, via the first portion of the Quantum Fragmentation instance, and persisting, via the first portion of the Quantum Fragmentation instance, each of the plurality of first data fragments to a data store of a plurality of available Cloud or other data stores or to a subsequent portion of the Quantum Fragmentation instance, wherein the persistence for each of the first data fragment occurs independently from the other first data fragments.

Abstract: A system and a method to obtain clearance is disclosed. The system includes user identification hardware configured to establish identity of the user. The system also includes a toilet configured to analyze a sample of excreta or sputum from the user, to thereby determine the status of the user with respect to a pre-determined condition. A processing module is configured to link the identity of the user with the status of the user. A communication module communicates information including the linked identity and status of the user to an authority. As such, the authority is provided the information required to grant or deny clearance to the user. Clearance may include allowing a user to use one or more forms of public transportation, be in places where large numbers of people congregate, participate in an athletic competition or other places or activities where the condition of the user may put themselves or others at risk.