Abstract: The subject invention concerns materials and methods for treating or preventing disease and conditions associated with various sulfatase enzymes that are defective or that are not properly expressed in a person or animal. In one embodiment, the disease is Sanfilippo A (MPS-IIIA) disease. The subject invention also concerns materials and methods for treating or preventing multiple sulfatase deficiency (MSD) in a person or animal. Compounds of the invention include a fusion protein comprising i) a mammalian sulfatase, or an enzymatically active fragment or variant thereof, and ii) a plant lectin or a binding subunit thereof. In a specific embodiment, the mammalian sulfatase is a human sulfatase, or an enzymatically active fragment or variant thereof. Polynucleotides encoding the fusion proteins are also contemplated for the subject invention. The subject invention also concerns materials and methods for producing proteins of the invention.

Abstract: A method of controlling motor velocity in a surgical instrument is disclosed. The surgical instrument includes a displacement member, a motor coupled to the displacement member, a control circuit coupled to the motor, a position sensor coupled to the control circuit, and a timer coupled to the control circuit. The method includes receiving a first position of a displacement member from a position sensor, starting a timer, advancing the displacement member to a second position by setting a motor velocity to a first velocity, receiving the second positon from the position sensor, stopping the timer when the displacement member reaches the second position, receiving elapsed time from the timer, wherein the elapsed time is the time taken by the displacement to move from the first position to the second positon, and controlling, by the control circuit, velocity of the motor based on the elapsed time.

Abstract: An encryption method comprises: creating an asymmetric profile key comprising a multipart threshold key using a set of user devices; signing a declaration using the profile key and the set of user devices, the declaration identifying the set of user devices; creating an asymmetric location key comprising two multipart threshold keys; sharding and storing the asymmetric location key; creating a symmetric key; encrypting a file with the symmetric key; encrypting the symmetric key with the location key; and storing the encrypted file and encrypted key such that the encrypted file cannot be decrypted without decrypting the location key by a threshold of the set of user devices.

Abstract: Wireless message faults are an increasing problem n 5G and especially 6G due to network crowding and pathloss attenuation at higher frequencies, among other emergent problems. Therefore, disclosed are methods to diagnose and repair faulted messages by the receiver. For example, an AI program can determine the signal quality of each message element according to the modulation quality, SNR, and other waveform measurements, and thereby identify just a portion of the message that contains all of the likely faults. That portion can then be retransmitted instead of the entire message, saving substantial time. In addition, the AI program can select which message elements of the two versions has the best signal quality, and prepare a merged message from those best-received signals.

Abstract: A gate safety system for preventing collisions between a vehicle and a gate is provided, the system having a gate module with a vehicle module, a gate antenna unit and a gate processing unit. The gate processing unit is adapted for defining a first gate warning zone and for determining whether a vehicle module is present within the first gate warning zone. The vehicle module includes a vehicle antenna unit and a vehicle processing unit adapted for defining at least one first vehicle warning zone for determining whether the gate module is present within the vehicle warning zone. A lock safety system, two methods for operating the gate safety system and the lock safety system, and two computer programs are also provided.

Abstract: A head unit system for controlling motion of an object includes a secondary object sensor, shear thickening fluid (STF), and a chamber configured to contain a portion of the STF. The chamber further includes a front channel and a back channel. The head unit system further includes a piston housed at least partially radially within the piston compartment and separating the back channel and the front channel. The piston includes a first piston bypass and a second piston bypasses to control flow of the STF between opposite sides of the piston. The chamber further includes a set of fluid manipulation emitters to control the flow of the STF to cause selection of one of a variety of shear rates for the STF within the chamber.

Abstract: A device that heats/cools air includes a heat exchanger that contains hydronic fluid; a blower that moves air over and/or through the heat exchanger; a pump that circulates the hydronic fluid; a first vessel that contains hydronic fluid under pressure, air, a sealed first opening, a second opening that allows the hydronic fluid to exit the first vessel, a third opening that allows the hydronic fluid to enter the vessel, and a fourth opening; a second vessel that contains hydronic fluid at atmospheric pressure, a sealed first opening, and a second opening in communication with the first vessel, wherein the second vessel is in communication with the fourth opening; a valve that allows hydronic fluid to flow from the second vessel to the first vessel when pressure inside the first vessel decreases below zero psig, and prevents hydronic fluid from flowing from the first vessel to the second vessel.

Abstract: A self-laminating rotating cable marker label is constructed of a transparent film having a first adhesive area, an adhesive-free smooth area, and a second adhesive area. A print-on area forms one side of the transparent film, the print-on area adapted to receive indicia identifying the cable about which the marker label is applied. A perforation extends across the transparent film providing a line of separation of the transparent film. When wrapped around a cable, the second adhesive area overlies the print-on area such that the cable identifying indicia is visible through the transparent second adhesive area. As the transparent film is wrapped around the cable, the first adhesive area adheres to the cable. The remainder of the transparent film is rotated, breaking the perforation, whereby the smooth area of the film in contact with the cable provides smooth rotation of the label around the cable.

Abstract: Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.

Abstract: The present invention is in the field of soybean variety EE1660019, EE1660070, EE1660299, EE1660534, EE1660343, EE1660277, EE1600331, or AR1502197 breeding and development. The present invention particularly relates to the soybean variety EE1660019, EE1660070, EE1660299, EE1660534, EE1660343, EE1660277, EE1600331, or AR1502197 and its seed, cells, germplasm, plant parts, and progeny, and methods of using EE1660019, EE1660070, EE1660299, EE1660534, EE1660343, EE1660277, EE1600331, or AR1502197 in a breeding program.

Abstract: The present invention relates to data rights management and more particularly to a secured system and methodology and production system and methodology related thereto and to apparatus and methodology for production side systems and are consumer side systems for securely utilizing protected electronic data files of content (protected content), and further relates to controlled distribution, and regulating usage of the respective content on a recipient device (computing system) to be limited strictly to defined permitted uses, in accordance with usage rights (associated with the respective content to control usage of that respective content), on specifically restricted to a specific one particular recipient device (for a plurality of specific particular recipient devices), or usage on some or any authorized recipient device without restriction to any one in specific, to control use of the respective content as an application software program, exporting, modifying, executing as an application program, viewing,

Abstract: The present disclosure provides reagent compounds, reactive biopolymeric compounds, and methods of making and using these materials for the rapid and efficient synthesis and purification of biopolymeric compounds at low cost. The materials and methods yield highly pure synthetic biopolymeric compounds, including synthetic oligonucleotides and polypeptides, and reduce or eliminate the need for toxic solvents in the synthetic process.

Abstract: A method, a system, and an article are provided for identification of security-related activities based on usage of a plurality of independent cloud-based, hosted application platforms. An example method includes: receiving, from the application platforms, activity data and state data for a plurality of users of the application platforms; generating one or more predictive models configured to detect deviations from normal user behavior across the application platforms; providing, as input to the one or more predictive models, the activity data and the state data for at least one of the users; receiving, from the one or more predictive models, an indication that an activity of the at least one of the users deviates from the normal user behavior; and facilitating a remedial action to address the indicated deviation.

Abstract: Methods and apparatus to calibrate media ratings based on return path data are disclosed. An apparatus includes programmable circuitry to execute machine readable instructions to: determine a subscriber calibration factor for media based on first panel tuning information obtained from first metering devices in first panelist households that subscribe to a content provider that provides media through return path data (RPD) devices; determine a nonsubscriber calibration factor for the media based on second panel tuning information obtained from second metering devices in second panelist households that do not subscribe to the content provider; and determine a final rating for the media based on an initial rating and at least one of the subscriber calibration factor or the nonsubscriber calibration factor, the initial rating based on RPD tuning information obtained from RPD devices in subscriber households that subscribe to the content provider.

Abstract: Digital image segmentation is provided. The method comprises training a neural network for image segmentation with a labeled training dataset from a first domain, wherein a subset of nodes in the neural net are dropped out during training. The neural network receives image data from a second, different domain. A vector of N values that sum to 1 is calculated for each image element, wherein each value represents an image segmentation class. A label is assigned to each image element according to the class with the highest value in the vector. Multiple inferences are performed with active dropout layers for each image element, and an uncertainty value is generated for each image element. Uncertainty is resolved according to expected characteristics. The label of any image element with an uncertainty above a threshold is replaced with a new label corresponding to a segmentation class based on domain knowledge.

Abstract: Provided herein are transmucosal and transdermal delivery systems comprising: at least one non-ionic surfactant; at least one polyol; and at least one active agent; and optionally further comprising at least one oil. In particular embodiments, the delivery system has an average particle size of from about 5 nm to about 200 nm.

Abstract: A computing device including a display screen, the computing device being configured to display on the screen a visual indication of a health status of a monitored application, wherein the screen displays a listing of interfaces, with each interface affecting the health of the application. Each interface is associated with physical host location(s) and the computing device is additionally configured to display on the display screen a set of status icons associated with each interface in the listing of interfaces. The status icons are simultaneously arranged in a first grouping to visually depict a physical host location associated with the interfaces and a second grouping to visually depict dependencies common between interfaces. Each status icon includes a visual indicator indicating an interface health status of the interface, and the combination of the visual indicators form the visual indication of the health status of the monitored application.

Abstract: Examples are provided herein that relate to solar heating with a solar refraction device. One example provides a solar heating system, comprising a container configured to enclose contents within the container in a closed configuration, and a solar refraction device comprising a lens array assembly having a plurality of lens array sub-assemblies, the lens array assembly configured to refract solar energy impinging on the lens array assembly to focus refracted solar energy at a plurality of focal points positioned to heat the contents enclosed within the container, each focal point corresponding to a corresponding lens array sub-assembly of the plurality of lens array sub-assemblies.

Abstract: In a method performed by a first node associated with a first domain of a communications network, a first message is sent (302) to a second node associated with a second domain of the communications network. The first message comprises an indication of a resource in the first domain that is available to the second domain. The first message further comprises an anonymised first global unique identifier associated with the first domain.