Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable.

Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable.

Abstract: A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means.

Abstract: A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means.

Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable.

Abstract: A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means.

Abstract: Endoprosthesis for delivery in a body lumen is provided. The endoprosthesis includes an annular element defined by a set of interconnected strut members, each strut member including a first end and a second end. The first end of selected pairs of circumferentially-adjacent strut members of the annular element are interconnected to define apices proximate a first longitudinal side of the annular element and the second end of selected pairs circumferentially-adjacent strut members are interconnected to define apices proximate a second longitudinal side of the annular element. At least one of the selected pairs of circumferentially-adjacent strut members has a modulator disposed proximate the apex defined there between, the modulator having a first mode to allow expansion of the annular element from an unexpanded configuration toward an expanded configuration and a second mode to resist contraction of the annular element from the expanded configuration toward the unexpanded configuration.

Abstract: An apparatus comprises a guidewire body and a light source. The guidewire body includes an optically transmissive element. The guidewire body is sized for insertion in a sinus ostium of a patient. The light source is in optical communication with the optically transmissive element of the guidewire body. The light source is operable to transmit infrared light or narrowband visible light through the optically transmissive element. A detector may be used to detect light transmitted by the optically transmissive element through the patient. The detector may include a camera or a photodetector. Glasses may be used to provide an overlay of a camera image or to filter out light to enable focusing on light of a specific wavelength. A beam processing element may be used to provide a beam waist with an average irradiance of more than 10 W/cm2 within the acceptance angle of the optically transmissive element.

Abstract: A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means.

Abstract: Endoprosthesis for delivery in a body lumen is provided. The endoprosthesis includes an annular element defined by a set of interconnected strut members, each strut member including a first end and a second end. The first end of selected pairs of circumferentially-adjacent strut members of the annular element are interconnected to define apices proximate a first longitudinal side of the annular element and the second end of selected pairs circumferentially-adjacent strut members are interconnected to define apices proximate a second longitudinal side of the annular element. At least one of the selected pairs of circumferentially-adjacent strut members has a modulator disposed proximate the apex defined there between, the modulator having a first mode to allow expansion of the annular element from an unexpanded configuration toward an expanded configuration and a second mode to resist contraction of the annular element from the expanded configuration toward the unexpanded configuration.

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration.

Abstract: A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means.

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration.