Abstract: A package (12, 14) contains a transdermal patch (1) releasably mounted on a release liner (3) larger than the patch so that a peripheral edge (1a, 1b) of the patch is spaced from the edge of the release liner (3) by a border (7). The package (12, 14) is shaped and being sufficiently rigid that said edge of the patch is maintained spaced from the package. The package comprises a container (12) and a closure (14). The container has a recess containing the patch (1) and the release liner (3), and the recess has a base (18, 22) which includes a raised portion (18) located in the base so that, with the patch (1) facing the base, the edge (1a, 1b) of the patch is maintained spaced from the base in any position of the release liner within the recess.

Abstract: This invention relates to a slow release nifedipine-containing pharmaceutical compositions and methods of making such compositions. The compositions of the inventions comprise a soluble carrier coated with nifedipine and polyvinylpyrrolidone and an acrylic based polymer. Nifedipine is present, in amorphous form, in excess amounts to polyvinylpyrrolidone and in equal or excess amounts to the acrylic based polymer.