Patents by Inventor David Tweardy

David Tweardy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF NEUROPATHIC PAIN USING STAT3 INHIBITORS
    Publication number: 20240226041
    Abstract: Disclosed herein are methods and compositions for treatment and prevention of neuropathic pain conditions. Aspects of the present disclosure are directed to methods for treatment of neuropathic pain conditions using STAT3 inhibitors. Certain aspects pertain to TTI-101 and methods for use in treatment of chemotherapy-induced peripheral neuropathy, mechanical nerve injury, and other neuropathic pain conditions. Also disclosed are methods for treatment of chemotherapy-induced peripheral neuropathy comprising administering TTI-101 and one or more chemotherapeutic agents to a subject with cancer.
    Type: Application
    Filed: May 5, 2022
    Publication date: July 11, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David TWEARDY, Moses Makokha KASEMBELI, Anniemieke KAVELAARS, Cobi Jacoba Johanna HEIJNEN
  • Structural requirements for STAT3 binding and recruitment to phosphotyrosine ligands
    Publication number: 20060148715
    Abstract: Inhibitors of Stat3 are disclosed, including small molecules and peptide mimetic inhibitors. Specific Stat3 inhibitors of the invention are useful as beta-turn mimetics. Also disclosed are pharmaceutical compositions of the Stat3 inhibitors of the invention, and methods for using the compounds of the invention to inhibit growth of a cell or to inhibit protein-protein interactions modulated by SH2 domains. Methods of screening for Stat3 inhibitors are also provided.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 6, 2006
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventor: David Tweardy