Abstract: The invention relates generally to serology assays and, more particularly, to high-throughput serology assays. One aspect of the invention provides a method of detecting a viral antibody in a biological sample of an individual, the method comprising: applying an antigen-containing fluid to an assay surface, the antigen-containing fluid containing an antigen for the vims to be detected and the assay surface containing a biological sample from the individual; removing the antigen-containing fluid from the assay surface; and determining whether the assay surface contains bound antigen.

Abstract: The present disclosure relates to novel multiple trigger monomer containing negative working photoresist compositions and processes. The processes involve removing acid-labile protecting groups from crosslinking functionalities in a first step and crosslinking the crosslinking functionality with an acid sensitive crosslinker in a second step. The incorporation of a multiple trigger pathway in the resist catalytic chain increases the chemical gradient in areas receiving a low dose of irradiation, effectively acting as a built in dose depend quencher-analog and thus enhancing chemical gradient and thus resolution, resolution blur and exposure latitude. The photoresist compositions utilize novel monomers and mixtures of novel monomers. The methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays.

Abstract: Methods and related reagents are disclosed for diagnosing cancer, prognosing cancer occurrence or recurrence, and/or monitoring cancer therapy, involving contacting a bodily fluid sample from a subject at risk of having cancer or cancer recurrence, or from a subject that has been treated for cancer wl fit (a) one or more first antibody detection marker molecules that hind to human autoantibodies against at least one tumor associated antigen (TAA); and (fa) one or more second antibody detection marker molecules that bind to human autoantibodies against at least one extractable nuclear antigen (ENA).

Abstract: The present disclosure relates to novel multiple trigger monomer containing negative working photoresist compositions and processes. The processes involve removing acid-labile protecting groups from crosslinking functionalities in a first step and crosslinking the crosslinking functionality with an acid sensitive crosslinker in a second step. The incorporation of a multiple trigger pathway in the resist catalytic chain increases the chemical gradient in areas receiving a low dose of irradiation, effectively acting as a built in dose depend quencher-analog and thus enhancing chemical gradient and thus resolution, resolution blur and exposure latitude. The photoresist compositions utilize novel monomers and mixtures of novel monomers. The methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays.

Abstract: The invention relates to macro and small molecule detection and, more particularly, to methods for detecting macro and small molecules, including bio-molecules, in a liquid or gaseous sample.

Abstract: Embodiments of the invention relate generally to devices and methods for pumping and controlling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.

Abstract: Embodiments of the invention relate generally to devices and methods for pumping and controlling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.

Abstract: Embodiments of the invention provide methods, systems, and devices for detection and measurement of an analyte or analytes. In one embodiment, the invention provides an assay system comprising a cartridge device including: one or more reservoir portions for holding one or more liquids; and at least one assay portion for receiving the one or more liquids from the at least one reservoir portion, the at least one assay portion having a plurality of binding sites over which the one or more liquids from the one or more reservoirs can be flowed repeatedly (more than one time); and a measurement device for measuring binding of one or more analytes in the one or more liquids to the plurality of binding sites.

Abstract: Embodiments of the invention relate generally to macro and small molecule detection and, more particularly, to methods for detecting macro and small molecules, including bio-molecules, in a liquid or gaseous sample. Methods according to embodiments of the invention are useful in the identification, discovery, and validation of biomarkers, as well as the screening of individuals for such biomarkers for diagnostic, therapeutic, and forensic purposes. In one embodiment, the invention provides a method of detecting an analyte in a fluid sample, the method comprising: passing a fluid sample containing a labeled analyte across at least one assay surface containing a capture agent for the analyte; detecting the labeled analyte; repeating the passing and detecting steps at least once; and creating a binding curve for the analyte based on the detecting of the labeled analyte.

Abstract: Embodiments of the invention include methods for detecting and determining the concentrations of macro and small molecules, including bio-molecules, in a liquid or gaseous sample.

Abstract: The invention is directed to tumor associated markers (TAMs) and autoantibody biomarkers that can be used diagnostically.

Abstract: Embodiments of the invention relate generally to devices and methods for pumping and controling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.

Abstract: The present invention relates to a nano-particle biochip substrate comprising a substrate having attached thereto (bearing), on or in a surface, nano-particles having a cross sectional diameter of from about 0.1 nm. to about 50 nm. and useful to immobilize one or more moieties of interest.

Abstract: Embodiments of the invention relate generally to macro and small molecule detection and, more particularly, to methods for detecting macro and small molecules, including bio-molecules, in a liquid or gaseous sample. Methods according to embodiments of the invention are useful in the identification, discovery, and validation of biomarkers, as well as the screening of individuals for such biomarkers for diagnostic, therapeutic, and forensic purposes. In one embodiment, the invention provides a method of detecting an analyte in a fluid sample, the method comprising: passing a fluid sample containing a labeled analyte across at least one assay surface containing a capture agent for the analyte; detecting the labeled analyte; repeating the passing and detecting steps at least once; and creating a binding curve for the analyte based on the detecting of the labeled analyte.

Abstract: The present invention relates to a nano-particle biochip substrate comprising a substrate having attached thereto (bearing), on or in a surface, nano-particles having a cross sectional diameter of from about 0.1 nm. to about 50 nm. and useful to immobilize one or more moieties of interest.