Abstract: A system for forming a fluid connection includes a first connector and a second connector. Both connectors include a tubular body having a membrane mounted on a distal end thereof. A support member facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant energy is applied to the abutted membranes so as to first sterilize the membranes and then melt the membranes so that a passage is formed therethrough.

Abstract: A system for forming a fluid connection includes a first connector and a second connector. Both connectors include a tubular body having a membrane mounted on a distal end thereof. A support member facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant energy is applied to the abutted membranes so as to first sterilize the membranes and then melt the membranes so that a passage is formed therethrough.

Abstract: A system for forming a fluid connection includes a first connector (12) and a second connector (14). Both connectors include a tubular body (18,18?) having a membrane (19,19?) mounted on a distal end (27) thereof. A support member (16) or other fastener (214,220) facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant or other form of energy is applied to the abutted membranes so as to sterilize the membranes and melt the membranes so that a passage is formed therethrough.

Abstract: A flexible bag having expansible and collapsible cells can be used in a liquid dispenser. A rigid manifold, and in one instance a rigid frame is provided in the bag to keep passages open in use and to isolate one of the cells from the remaining cells. The manifold is capable of altering the volume of one of the cells so that the same bag can be used in different applications.

Abstract: A liquid dispenser uses a flexible bag having expansible and collapsible cells. A rigid manifold, and in one instance a rigid frame is provided in the bag to keep passages open in use and to isolate one of the cells from the remaining cells. The dispenser employs an efficient and quiet air pressure operating system. In one application, a concentrated drink mix may be held in a reservoir and diluted within other cells in the bag for dispensing to a cup or the like. A valve system allows for the particulates in the liquid without compromising the function of the valve.

Abstract: A liquid dispenser uses a flexible bag having expansible and collapsible cells. A rigid manifold, and in one instance a rigid frame is provided in the bag to keep passages open in use and to isolate one of the cells from the remaining cells. The dispenser employs an efficient and quiet air pressure operating system. In one application, a concentrated drink mix may be held in a reservoir and diluted within other cells in the bag for dispensing to a cup or the like. A valve system allows for the particulates in the liquid without compromising the function of the valve.

Abstract: A multi-layer, flexible, gas-permeable film (10) suitable for forming a cell culture container (20), the film (10) comprising a first layer (12) composed of a polystyrene having a thickness within the range of 0.0001 inches to about 0.0010 inches and, a second layer (14) adhered to the first layer (12) composed of a polyolefin having a thickness within the range of 0.004 inches to about 0.015 inches.

Abstract: A resealable access site (10) is provided for allowing a cannula (18) multiple accesses to an internal cavity (35) defined by a container (12). The access site (10) includes a first conduit (28) defining a passageway (29) forming a fluid path to the cavity within the container. Sealingly attached to the conduit (28) is a housing (26) with a lower portion (26a) and a lower flange (68) attached to a lower end of the lower portion and extending radially inward from the lower portion. A septum (24) is disposed and compressed within the lower portion, with the septum defining an opening (46) extending upward through at least a portion of the septum. The opening (46) is sized for insertion of the cannula (18) through the septum (24) with the septum sealing about the exterior of the cannula. The septum (24) is maintained in the housing by the support provided by the opposing flange (68) and conduit (28).

Abstract: A multiple layer structure comprising a skin layer, a barrier layer, a radio frequency susceptible layer having a first polyolefin in an amount within a range of 30-60% by weight, a second polyolefin in an amount within the range of 25-50% by weight, a radio frequency susceptible polymer in an amount within the range of 3-40% by weight, a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the sealant layer.

Abstract: A multi-layer, flexible, gas-permeable film (10) suitable for forming a cell culture container (20), the film (10) comprising a first layer (12) composed of a polystyrene having a thickness within the range of 0.0001 inches to about 0.0010 inches and, a second layer (14) adhered to the first layer (12) composed of a polymer material having a thickness within the range of 0.004 inches to about 0.025 inches.

Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.

Abstract: A multiple layer structure comprising a skin layer, a barrier layer, a radio frequency susceptible layer having a first polyolefin in an amount within a range of 30-60% by weight, a second polyolefin in an amount within the range of 25-50% by weight, a radio frequency susceptible polymer in an amount within the range of 3-40% by weight, a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the sealant layer.

Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.

Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.

Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.

Abstract: An adherent cell culture flask is provided. The flask includes a body constructed from a first side wall and a second side wall, each side wall having an interior surface and an exterior surface. The first and second side walls are sealed together to define a chamber. The first side wall is constructed from flexible film and includes on its interior surface a charged surface for facilitating the attachment of cells thereto. The second side wall is constructed from flexible film and includes a non-smooth interior surface for preventing the first side wall interior surface from sticking to the second side wall interior surface.

Abstract: A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.

Abstract: A cell culture media container is provided. The container comprises a body constructed from flexible film and defining a containment area for containing the cell culture media, the body including a front face and a back face, the front and back face being sealed to each other along at least three sides thereof. The container includes a fill port for filling the containment area with cell culture media, the port being sealed to a face of the body and being so constructed and arranged that it extends from the face normal thereto. The container is constructed from a high barrier, optically clear, radiation sterilizable film.

Abstract: A fluid delivery system has a container with an integrally attached sample cell. A selected fluid can be accumulated in the container. The sample cell can be filled with part of the fluid in the container and then isolated from the container by heat or dielectric sealing. The fluid in the sample cell can be brought into contact with selected test reagents. The test reagents can provide a visual indicia of the presence of selected characteristics in the fluid.

Abstract: A fluid delivery system has a container with an integrally attached sample cell. A selected fluid can be accumulated in the container. The sample cell can be filled with part of the fluid in the container and then isolated from the container by heat or dielectric sealing. The fluid in the sample cell can be brought into contact with selected test reagents. The test reagents can provide a visual indicia of the presence of selected characteristics in the fluid.