Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Abstract: A stand-by uninterruptible power supply which provides for extended backup time and/or an increase in power rating for stand-by power supply applications. The uninterruptible power supply also has a waveshape circuit for rating the power capacity of the supply. The waveshape circuit provides a more effective way of rating the capacity of the power supply so that different supplies may be easily compared with little confusion.