Patents by Inventor David V. Erbe

David V. Erbe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION
    Publication number: 20230121944
    Abstract: The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the HAO1 gene, and methods of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Application
    Filed: August 15, 2022
    Publication date: April 20, 2023
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION
    Publication number: 20220403394
    Abstract: The invention relates methods of using RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Application
    Filed: January 20, 2022
    Publication date: December 22, 2022
    Inventors: David V. Erbe, Tracy L. McGregor
  • Compositions and Formulations and Methods of Production and Use Thereof
    Publication number: 20220347262
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: December 2, 2021
    Publication date: November 3, 2022
    Inventors: Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
  • IL-6 antagonists and uses thereof
    Patent number: 11459386
    Abstract: Interleukin-6 (IL-6) antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases, e.g., disease of the eye such as diabetic macular edema are disclosed.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: October 4, 2022
    Assignee: Sesen Bio, Inc.
    Inventors: Michael March Schmidt, Thomas M. Barnes, David V. Erbe, Eric Steven Furfine, Alison Tisdale
  • Compositions and methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
    Patent number: 11446380
    Abstract: The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the HAO1 gene, and methods of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: September 20, 2022
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
    Patent number: 11261447
    Abstract: The invention relates methods of using RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 1, 2022
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: David V. Erbe, Tracy L. McGregor
  • Compositions and Formulations and Methods of Production and Use Thereof
    Publication number: 20200405807
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: July 1, 2020
    Publication date: December 31, 2020
    Inventors: Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
  • COMPOSITIONS AND METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION
    Publication number: 20200316201
    Abstract: The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the HAO1 gene, and methods of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Application
    Filed: November 4, 2019
    Publication date: October 8, 2020
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • Methods For Inhibition Of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression
    Publication number: 20200165616
    Abstract: The invention relates methods of using RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Application
    Filed: July 12, 2018
    Publication date: May 28, 2020
    Inventor: David V. Erbe
  • Compositions and methods for inhibition of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) gene expression
    Patent number: 10478500
    Abstract: The invention relates to RNAi agents, e.g. double-stranded RNAi agents, targeting the HAO1 gene, and method of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1. Described herein are double-stranded RNAi agents which inhibit the expression of a HA01 gene in a cell, such as a cell within a subject, e.g., a mammal, such as a human having a HAO1 associated disorder, and uses of such double-stranded RNAi agents. In certain aspects of the invention, substantially all of the nucleotides of an iRNA of the invention are modified.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 19, 2019
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • IL-6 ANTAGONISTS AND USES THEREOF
    Publication number: 20180222975
    Abstract: IL-6 antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases, e.g., disease of the eye such as diabetic macular edema are disclosed.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 9, 2018
    Inventors: Michael March Schmidt, Thomas M. Barnes, David V. Erbe, Eric Steven Furfine, Alison Tisdale
  • Compositions and Formulations and Methods of Production and Use Thereof
    Publication number: 20180125926
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: October 4, 2017
    Publication date: May 10, 2018
    Inventors: Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
  • IL-6 antagonists and uses thereof
    Patent number: 9951130
    Abstract: Interleukin 6 (IL-6) antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases, e.g., disease of the eye such as diabetic macular edema are disclosed.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: April 24, 2018
    Assignee: ELEVEN BIOTHERAPEUTICS, INC.
    Inventors: Michael March Schmidt, Thomas M. Barnes, David V. Erbe, Eric Steven Furfine, Alison Tisdale
  • Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
    Patent number: 9878004
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: January 30, 2018
    Assignee: Axcella Health Inc.
    Inventors: Alison Williams, Michael J. Hamill, Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, David V. Erbe, Chung-Wei Lee, Luke Hamm
  • Compositions and Methods for Inhibition of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression
    Publication number: 20170304446
    Abstract: The invention relates to RNAi agents, e.g. double-stranded RNAi agents, targeting the HAO1 gene, and method of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1. Described herein are double-stranded RNAi agents which inhibit the expression of a HA01 gene in a cell, such as a cell within a subject, e.g., a mammal, such as a human having a HAO1 associated disorder, and uses of such double-stranded RNAi agents. In certain aspects of the invention, substantially all of the nucleotides of an iRNA of the invention are modified.
    Type: Application
    Filed: October 9, 2015
    Publication date: October 26, 2017
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • Compositions and Formulations for Increasing Renal Function and Treatment and Prevention of Renal Diseases, and Methods of Production and Use Thereof
    Publication number: 20160354436
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: December 8, 2016
    Inventors: Alison WILLIAMS, Nathaniel W. SILVER, Andrew DOWNEY, David V. ERBE, Michael J. HAMILL, David Arthur BERRY
  • Compositions and Formulations for Treatment of Gastrointestinal Tract Malabsorption Diseases and Inflammatory Conditions and Methods of Production and Use Thereof
    Publication number: 20160317614
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: November 3, 2016
    Inventors: Alison Williams, Michael J. Hamill, Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, David V. Erbe, Chung-Wei Lee, Luke Hamm
  • Compositions and Formulations for Prevention and Reduction of Tumorigenesis, Cancer Cell Proliferation and Invasion, and Methods of Production and Use Thereof in Cancer Treatment
    Publication number: 20160228506
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 24, 2014
    Publication date: August 11, 2016
    Inventors: Noubar B. Afeyan, Chung-Wei Lee, Nathaniel W. Silver, David Arthur Berry, Michael J. Hamill, David V. Erbe
  • Compositions and Formulations for Maintaining and Increasing Muscle Mass, Strength, and Performance and Methods of Production and Use Thereof
    Publication number: 20160219910
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 4, 2016
    Inventors: Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, Michael J. Hamill, Subhayu Basu, Luke Hamm, Alison Williams, David V. Erbe, Geoffrey von Maltzahn
  • IL-6 ANTAGONISTS AND USES THEREOF
    Publication number: 20150125468
    Abstract: IL-6 antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases, e.g., disease of the eye such as diabetic macular edema are disclosed.
    Type: Application
    Filed: October 7, 2014
    Publication date: May 7, 2015
    Applicant: ELEVEN BIOTHERAPEUTICS, INC.
    Inventors: Michael March Schmidt, Thomas M. Barnes, David V. Erbe, Eric Steven Furfine, Alison Tisdale