Patents by Inventor David V. Liu

David V. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant interleukin-2 (IL-2) polypeptides
    Patent number: 8906356
    Abstract: The present invention relates to mutant IL-2 polypeptides that act as receptor antagonists. The mutant IL-2 polypeptides bind CD 25 but do not activate the IL-2 receptor. Also provided are methods of using the mutant IL-2 polypeptides, for example, to treat a patient who has cancer or a viral infection. The mutant polypeptides can also be used in various delivery systems.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: December 9, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: K. Dane Wittrup, David V. Liu
  • MUTANT INTERLEUKIN-2 (IL-2) POLYPEPTIDES
    Publication number: 20110091412
    Abstract: The present invention relates to mutant IL-2 polypeptides that act as receptor antagonists. The mutant IL-2 polypeptides bind CD 25 but do not activate the IL-2 receptor. Also provided are methods of using the mutant IL-2 polypeptides, for example, to treat a patient who has cancer or a viral infection. The mutant polypeptides can also be used in various delivery systems.
    Type: Application
    Filed: November 5, 2008
    Publication date: April 21, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: K. Dane Wittrup, David V. Liu