Abstract: Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism.

Abstract: Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism.

Abstract: Methods and systems to perform point-of-care, user-initiated fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems. Exemplary assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An exemplary assay system includes a housing having one or more fluid chambers, a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The actuator may be configured to move fluid controllers from functionally closed positions to functionally open positions, to control fluid flow from the fluid chambers. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids.

Abstract: Methods and systems to prepare a sample, including a relatively small amount of a biological sample, and to mix the sample with preparation fluid stored in a device. The device may include multiple fluid chambers and a stepped plunger to force a fluid in at least one of the chambers into a sample receiving chamber and then to a storage chamber. Methods and systems disclosed herein may be implemented to collect and controllable mix a sample for analysis and/or storage.

Abstract: Methods and systems to related to sample collection, assays, and fluid control and management, including methods and systems to implement hand-held portable assays, to activate an assay system, to collect and prepare samples, to capture antibodies, and to trap or capture gas bubbles. Methods and systems disclosed herein, and portions thereof, may be implemented alone and/or in various combinations with one another.

Abstract: Methods and systems to perform point-of-care, user-initiated fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems. Exemplary assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An exemplary assay system includes a housing having one or more fluid chambers, a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The actuator may be configured to move fluid controllers from functionally closed positions to functionally open positions, to control fluid flow from the fluid chambers. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids.

Abstract: An adjustable attachment mechanism includes an elongate shaft, first and second seats disposed on opposite ends of the shaft, first and second collars, and an actuator. The first and second collars are disposed to translate along the elongate shaft. An inner surface of the first collar cooperates with the first seat to define a first receptacle and an inner surface of the second collar cooperates with the second seat to define a second receptacle. The actuator is in communication with the first and second collars and is actuable to selectively traverse the first and second collars along the shaft in a first direction away from each other and in a second direction toward each other, the movement in the first direction loosening the first and second receptacles and the movement in the second direction tightening the first and second receptacles.

Abstract: A headset for operably disposing a virtual display and optional speaker on the head of a user. The headset, including a cantilevered arm coupled to the headset with a pivot, including a hemispherical dome with at least three points of contact with the display support cantilever arm, and thus the headset, also including a stabilizer further stabilizing the virtual display with respect to the user.

Abstract: An imaging device for operably disposing a virtual display in front of each eye of a user and an optional speaker attachable to the imaging device. The imaging device of the present invention includes a binocular frame for securing the imaging device to the user including two adjustable bows such that the virtual display of the imaging device is adjustable and pivotable to at least viewing positions with respect to the line of sight of the user.

Abstract: An imaging device for operably disposing a virtual display in front of each eye of a user and an optional speaker attachable to the imaging device. The imaging device of the present invention includes a binocular frame for securing the imaging device to the user including two adjustable bows such that the virtual display of the imaging device is adjustable and pivotable to at least two viewing positions with respect to the line of sight of the user.

Abstract: A headset for operably disposing a virtual display and optional speaker on the head of a user. The headset, including a cantilevered arm coupled to the headset with a pivot, including a hemispherical dome with at least three points of contact with the display support cantilever arm, and thus the headset, also including a stabilizer further stabilizing the virtual display with respect to the user.

Abstract: A container comprising a cover and a containing portion, the cover adapted to fit adjacent a portion of an inner edge of the containing portion. The cover including a body portion having an opening therein, and a stopper movable between an open position and a closed position, the stopper adapted to close the opening when the stopper is in the closed position, thereby causing an air-tight seal between the cover and the containing portion and allows the cover to be removed from the container when the stopper is in the open position by releasing the air-tight seal.