Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

Abstract: A method for ink jet printing of a substrate, as well as an ink jet printed layer. To provide a method for ink jet printing of a substrate that is particularly fast and energy-conserving and does not require any systems with high procurement and operating costs, initially a substrate is supplied, which is then coated with a layer of a print medium on at least one surface. A labeling of the substrate is carried out by applying the same print medium to result in a different color shade of the printed layer.

Abstract: A method for producing a labeled printed circuit board, as well as a labeled electric printed circuit board. In order to provide a method for producing a labeled printed circuit board that is particularly fast and energy-conserving and does not require any systems with high procurement and operating costs, initially a substrate with conductor tracks is supplied, which is then coated with a functional lacquer layer on at least one surface. A labeling of the substrate in different color shades of the functional lacquer layer is also carried out.

Abstract: The invention relates to a method for producing a labeled printed circuit board, as well as a labeled electric printed circuit board. In order to provide a method for producing a labeled printed circuit board that is particularly fast and energy-conserving and does not require any systems with high procurement and operating costs, initially a substrate with conductor tracks is supplied which is then coated with a functional lacquer layer on at least one surface, wherein a labeling of the substrate in different color shades of the functional lacquer layer is also carried out.

Abstract: Methods and apparatus are provided to monitor and analyze activity occurring on a networked computer system. In some embodiments, a method is provided for capturing, in a data structure, at least a portion of a notification describing a network event provided by a node on a computer network, identifying a data element (e.g., an IP address of the node) within the notification, and updating an index and/or summary based on the data element. The data structure may be stored in a file system maintained on a site, and sites may exchange information related to the notification data stored on each. In some embodiments, a query which is issued to a site may be processed using data transferred from other sites, and/or may be split into one or more additional queries which may be transmitted for processing to other sites.

Abstract: Methods and apparatus are provided to monitor and analyze activity occurring on a networked computer system. In some embodiments, a method is provided for capturing, in a data structure, at least a portion of a notification describing a network event provided by a node on a computer network, identifying a data element (e.g., an IP address of the node) within the notification, and updating an index and/or summary based on the data element. The data structure may be stored in a file system maintained on a site, and sites may exchange information related to the notification data stored on each. In some embodiments, a query which is issued to a site may be processed using data transferred from other sites, and/or may be split into one or more additional queries which may be transmitted for processing to other sites.

Abstract: Methods and apparatus are provided to monitor and analyze activity occurring on a networked computer system. In some embodiments, a method is provided for capturing, in a data structure, at least a portion of a notification describing a network event provided by a node on a computer network, identifying a data element (e.g., an IP address of the node) within the notification, and updating an index and/or summary based on the data element. The data structure may be stored in a file system maintained on a site, and sites may exchange information related to the notification data stored on each. In some embodiments, a query which is issued to a site may be processed using data transferred from other sites, and/or may be split into one or more additional queries which may be transmitted for processing to other sites.

Abstract: A diving board lift assembly for lifting a diving board from a substantially horizontal diving position to a substantially upright position is provided. The diving board having a diving end and a hinged end with the hinged end hingedly connected to a diving board support member. To raise the diving board, an actuator is rotated in a clockwise direction which rotation causes a portion of the top assembly to the lift mechanism to make contact with and raise the diving board to a near vertical position. To lower the diving board to its original position, the actuator need simply be rotated in a counter-clockwise direction.

Abstract: We present, in exemplary embodiments of the present invention, novel systems and methods for syndromic surveillance that can automatically monitor symptoms that may be associated with the early presentation of a syndrome (e.g., fever, coughing, sneezing, runny nose, sniffling, rashes). Although not so limited, the novel surveillance systems described herein can be placed in common areas occupied by a crowd of people, in accordance with local and national laws applicable to such surveillance. Common areas may include public areas (e.g., an airport, train station, sports arena) and private areas (e.g., a doctor's waiting room). The monitored symptoms may be transmitted to a responder (e.g., a person, an information system) outside of the surveillance system, such that the responder can take appropriate action to identifying, treat and quarantine potentially infected individuals, as necessary.

Abstract: We present, in exemplary embodiments of the present invention, novel systems and methods for syndromic surveillance that can automatically monitor symptoms that may be associated with the early presentation of a syndrome (e.g., fever, coughing, sneezing, runny nose, sniffling, rashes). Although not so limited, the novel surveillance systems described herein can be placed in common areas occupied by a crowd of people, in accordance with local and national laws applicable to such surveillance. Common areas may include public areas (e.g., an airport, train station, sports arena) and private areas (e.g., a doctor's waiting room). The monitored symptoms may be transmitted to a responder (e.g., a person, an information system) outside of the surveillance system, such that the responder can take appropriate action to identifying, treat and quarantine potentially infected individuals, as necessary.

Abstract: A diving board lift assembly for lifting a diving board from a substantially horizontal diving position to a substantially upright position is provided. The diving board having a diving end and a hinged end with the hinged end hingedly connected to a diving board support member. In accordance with the present invention, a lifting mechanism is provided to lift the diving end of the diving board to the substantially upright position.

Abstract: A lens for use in indirect ophthalmoscopy having two functions; firstly as a condensing lens converging light from an ophthalmoscope light source to the pupil of the eye and thereby illuminating the fundus of the eye, and secondly and simultaneously as an image forming lens which forms an aerial image of the fundus of the eye, which image is viewed monocularly with a monocular indirect ophthalmoscope or binocularly and stereoscopically with a binocular indirect ophthalmoscope.

Abstract: This invention pertains to a novel compact hand-held optical system whch is used both as a light condenser and as an aerial image former in the examination of the fundus of the eye with the indirect ophthalmoscope and with the slit lamp biomicroscope.The novel optical system has the unique feature that the aerial image of the fundus produced by it is upright rather than inverted as in the present state of the art with hand-held indirect ophthalmoscopy lenses. The novel optical system consists of three coaxial air-spaced double aspheric lenses which are so designed and positioned as to converge the illuminating light beam from the light source such that an image of said source is formed at the center of the pupil of the examined eye, the light then diverging from said image to illuminate the fundus of the eye.

Abstract: This invention relates to an improved aspheric posterior chamber intraocular lens and lens series of said novel intraocular lens, which lens is used as a replacement within the eye for the absent human crystalline lens, and a simplified method of selecting a lens from said lens series for use in a given eye. The novel lens of this invention is designed to have a continuously and regularly increasing refractive power from its axis peripheralward in its optically active area and to achieve the following results: the correction of the axial refractive error of the aphakic eye in which it is placed, and the production of clear central vision over a continuous range of distances from far to near, where far is defined as six meters and beyond, and near or reading distance is defined as generally 40 cm from the eye but may be as close as 33 cm.

Abstract: There is presented an improved head-borne binocular indirect ophthalmoscope for viewing the aerial image of the fundus of the eye, having the unique feature that it incorporates within each of its two observing portions a two-lens telescope of low magnifying power which magnifies said aerial image of the fundus. The telescope incorporated into the ophthalmoscope differs from the usual coaxial type in that the optical axis of the high powered objective lens and that of the high powered ocular lens of said telescope are caused to intersect each other at an angle of about 94.degree.

Abstract: A contact lens is disclosed wherein at least one of its surfaces, generally the posterior surface, is an aspheric surface of revolution which decreases in curvature from its apex to its periphery and which varies in a continuous and regular manner in eccentricity from its apex to its periphery. The novel surface is defined in terms of three parameters: apical radius of curvature; apical eccentricity; and collectively one or more derivatives of eccentricity. The lens with the novel surface posterior is so designed that the novel surface approximates the contour of the cornea while at the same time producing optical properties in the lens for optimal correction of the refractive error of the non-presbyopic eye, and when presbyopia exists, for the correction of the refractive error of the eye and presbyopia.

Abstract: A very strong plus symmetrical double aspheric lens is used as a condensing-image-forming lens for indirect ophthalmoscopy with the slit lamp biomicroscope. The patient is seated at the slit lamp biomicroscope with his head held firmly in position by the chin rest and head support. The light beam from the slit lamp, with its slit open fully, is directed at the indirect ophthalmoscopy lens of this invention which converges the light beam to an image of the light source at or near the center of the pupil of the eye. The light beam then diverges to illuminate the fundus of the eye. An inverted aerial image of the fundus of the eye is then formed by the lens of this invention of the light emerging from the eye and is viewed monocularly or binocularly and stereoscopically with the binocular biomicroscope of the slit lamp which can magnify the aerial image from 7 to 40 times.

Abstract: This invention consists of an improvement in known measuring microscopes and the method of use of such microscope for measuring radii of curvature of contact lens surface areas by catoptric imagery, by attaching a novel lens holding stage with an adjustable lens holder to the measuring microscope below the objective lens thereof and supporting an optical contact lens, either semi-finished or finished, in said holder, with provisions for tilting the lens holder of the stage a selected angular amount about a lens holder axis and translating the lens holder along a horizontal translation axis perpendicular to the lens holder axis, both the lens holder axis and the horizontal translation axis being perpendicular to the optical axis of the microscope, the horizontal translation axis intersecting both the optical axis of the microscope and the lens holder axis, tilting the optical contact lens a given angular amount about the lens holder axis and translating the lens along the horizontal translation axis in such a

Abstract: There is presented a multifocal ophthalmic lens of homogeneous transparent optical material and method and apparatus for forming same, useful for the correction of the refractive error and the accommodative insufficiency or absence of accommodation in presbyopia and in aphakia, the lens characterized by having a unique variable front surface and a coacting spherical or toric back surface, said variable front surface characterized by being geometrically and optically regular and continuous and having a pair of intersecting orthogonal principal planes, the first of said planes, generally horizontal, intersecting said variable surface normally at all points in a circular or elliptical or substantially elliptical great arc, the derivative of curvature vanishing at said great arc in sections orthogonal to it; the second of said planes, generally vertical, intersecting said variable surface normally at all points in a principal curve, about which there is symmetry, at least the portion of said principal curve below