Abstract: The present invention relates, in general, to protein modifications and, in particular, to a method of effecting site-specific labeling of proteins with covalently coupled reporter groups. The invention further relates to a method of effecting orientation-specific immobilization of proteins on a solid surface. The invention also relates to products produced by such methods.

Abstract: The present invention relates to a manual brake release mechanism for an electromagnetic brake of an electronic motor. The manual brake release mechanism includes a cam and lever assembly operable to move an armature plate away from a friction disk, thereby, disengaging an electromagnetic brake. The cam and lever assembly is coupled to a field cup and provides an even pull over both sides of the armature plate.

Abstract: The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is site-specifically attached to the surface of the macromolecule is between the macromolecule and electrode surface ligand-mediated conformational changes alter the geometry of interaction between the redox cofactor and the electrode surface resulting in a change in electronic coupling between the cofactor and electrode.

Abstract: The present invention provides for a system and method for integrating an electric motor with an electromagnetic brake. An integral field cup and front end shield is employed to function as both a brake field cup and a motor end shield. The integral field cup and front end shield houses a bearing assembly for the motor and an electromagnetic coil for the brake. Moreover, the integral field cup and front end shield operatively encloses the opposite drive end of the motor. In addition, an internal fan is positioned at the opposite drive end of the motor outside the brake and is operable to cool both the brake and the motor.

Abstract: An over the highway vehicle having a body defining an occupant space and an access opening to the space is provided. A passenger access door is pivotally connected to the body. The door has pivotally connected upper and lower sections and is pivotal relative to the body between a closed position and partial and full open positions allowing unobstructed passage into and out of the space. The lower section is pivotal relative to the upper section between an aligned condition for closing the opening and a condition wherein the panels are generally juxtaposed. A tether is interposed between the cab and the lower section for limiting pivotal movement of the door when the door is in its aligned condition to the partially open position and permitting movement of the door to the full open position when the door is in the juxtaposed condition.

Abstract: An over the highway vehicle having a body defining an occupant space and an access opening to the space is disclosed. A passenger access door is pivotally connected to the body. The door has pivotally connected upper and lower sections and is pivotal relative to the body between a closed position and partial and full open positions allowing unobstructed passage into and out of the space. The lower section is pivotal relative to the upper section between an aligned condition for closing the opening and a condition wherein the panels are generally juxtaposed. The sections being in a generally vertically aligned relationship when in the aligned condition and in generally side by side relationship, when in the juxtaposed condition. A tether is interposed between the cab and the lower section for limiting pivotal movement of the door when the door is in its aligned condition to the partially open position and permitting movement of the door to the full open position when the door is in the juxtaposed condition.

Abstract: The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is site-specifically attached to the surface of the macromolecule is between the macromolecule and electrode surface ligand-mediated conformational changes alter the geometry of interaction between the redox cofactor and the electrode surface resulting in a change in electronic coupling between the cofactor and electrode.

Abstract: A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm−1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm−1.

Abstract: A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm.sup.-1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm.sup.-1.

Abstract: The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.

Abstract: A labeled compound detectable by IR spectroscopy contains at least one hidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm.sup.-1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm.sup.-1.

Abstract: O-nitrobenzyl analogs that include a photoremovable protecting group that resists the nonspecific adsorption of biomolecules and a linking group for attaching the o-nitrobenzyl analog to a substrate are disclosed. Also disclosed are methods for using o-nitrobenzyl analogs for creating patterned arrays of anti-ligands on a substrate so that a plurality of bioassays can be conducted simultaneously. In particular, the compounds disclosed are o-nitrobenzyl-polyethylene glycol-silanes, wherein the silane group serves to attach the compound to a substrate, the polyethylene glycol group resists the nonspecific adsorption of biomolecules. The o-nitrobenzyl group provides a photoactivatable functionality that allows the polyethylene glycol group to be selectively removed upon exposure to UV radiation and be replaced by an anti-ligand.

Abstract: The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.