Abstract: Adriamycin octanoylhydrazone, and its pharmaceutically acceptable salts, having good antitumor activity coupled with low toxicity.

Abstract: N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and daunomycin, said derivatives having anticancer properties and being active against leukemia P-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibiting a loss of DNA-binding properties.

Abstract: Glyoxylic acid hydrocarbylsulfonylhydrazones and therapeutic compositions containing the same. Said compounds are useful in treating cancer, they being active against leukemia P-388, for example.

Abstract: Described are N,N-pentamethylene derivatives of daunomycin and adriamycin having the formula: ##STR1## wherein R.sup.1 is --COCH.sub.3 or --CHOHCH.sub.3 in the case of daunomycin derivatives, or --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of adriamycin derivatives. The compounds have utility as antitumor agents.

Abstract: N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and daunomycin, said derivatives having anticancer properties and being active against leukemia P-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibiting a loss of DNA-binding properties.

Abstract: Rubidazone analogs wherein the phenyl group is substituted by one of 4-phenyl, 4-chloro, 3,4-dichloro or 3-nitro, said compounds having high antitumor activity coupled with desirably low cardiotoxicity.

Abstract: Bis-hydrazones of daunomycin and adriamycin having useful antitumor characteristics and the structure ##STR1## WHEREIN N IS AN INTEGER HAVING A VALUE OF FROM 0 THROUGH 8 AND THE RADICALS INDICATED BY R and R' each represent hydrogen except that in those instances in which n has a value of 2, the R groups, if not hydrogen, may be methyl radicals (with R' remaining as hydrogen), and the R' groups, if not hydrogen, may be hydroxy radicals (with R remaining as hydrogen).

Abstract: 5-Iminodaunomycin having good antitumor activity coupled with low cardiotoxicity.

Abstract: The compounds 3-(N-diethylcarbamyl)amino-1-methyl pyrrolidine, 3-(N-carbethoxy-N-methyl)amino-1-methyl pyrrolidine, 1-diethylcarbamyl-3-(N-methyl)amino pyrrolidine and 1-diethylcarbamyl-3-dimethylamino pyrrolidine, said compounds having utility as antifilarial agents.

Abstract: A process for the synthesis of adriamycin and 7,9-epiadriamycin, both active antineoplastic agents, in which 7-deoxydaunomycinone, in either the 9s or racemic (.+-.) form, is employed as the starting material, the process in one embodiment also being productive of the useful intermediate compound 4-methoxy-6,11-dihydroxy-7,8-dihydro-5,9(10H),12-naphthacenetrione. The process involves converting 7-deoxydaunomicinone successively to daunomycinone, adriamycinone, 14-0-p-anisyldiphenylmethyladriamycinone and finally to adriamycin or to both adriamycin and 7,9-epiadriamycin. When producing the latter mixture of diastereomers, the 7-deoxydaunomycinone starting material is first converted to racemate form by a process involving the successive production of 7-deoxydaunorubicinol, 4-methoxy-6,11-dihydroxy-7,8-dihydro-5,9(10H), 12-naphthacenetrione, (.+-.)-4-methoxy-9-cyano-6,9,11-trihydroxy-7,8,9,10-tetrahydro-5,12-naphth acenedione, (.+-.

Abstract: N-substituted 2-[2-(5-nitro-2-furyl)vinyl]imidazoles having the structure ##STR1## wherein R represents mono- or dimethoxybenzyl, pyridylmethyl, N,N-dimethylaminobenzyl or phenoxypropyl. A preferred compound is 1-(4-methoxybenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole. The compounds have utility as antischistosomal chemotherapeutic agents.

Abstract: The compounds 4-carbethoxy-1,4-diazabicyclo[3.2.1]octane and 4-diethylcarbamyl-1,4-diazabicyclo[3.2.1]octane, said compounds having utility as antifilarial agents.

Abstract: Twelve analogs of diethylcarbamazine as prepared by acylation of 3- and 8-methyl-3,8-diazabicyclo[3.2.1]octane, 2-methyl-2,5-diazabicyclo[2.2.2]octane, and 2-methyl-2,5-diazabicyclo[2.2.1]heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from diethylcarbamazine in possessing two- or one-carbon bridges over the piperazine ring. The compounds have utility as antifilarial agents and as bronchodilators.

Abstract: Twelve analogs of diethylcarbamazine as prepared by acylation of 3- and 8-methyl-3,8-diazabicyclo[3.2.1]octane, 2-methyl-2,5-diazabicyclo[2.2.2]octane, and 2-methyl-2,5-diazabicyclo [2.2.1]heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from diethylcarbamazine in possessing two- or one-carbon bridges over the piperazine ring. The compounds have utility as antifilarial agents and as bronchodilators.

Abstract: New 3-methyl-3-nitrosoureido derivatives of the following amino sugars were prepared as analogs of streptozotocin with the anomeric carbon protected, by nitrosating the methylureas in water with N.sub.2 O.sub.3 : 3-amino-3-deoxy-1,2-O-isopropylidene-.alpha.-D-ribofuranose; methyl 3-amino-3-deoxy-.beta.-D-xylopyranoside; methyl 3-amino-3-deoxy-.alpha.-D-altropyranoside; methyl 3-amino-3-deoxy-.alpha.-D-glucopyranoside; and methyl 3-amino-2,3,6-trideoxy-.alpha.-L-lyxohexopyranoside. Tests against murine leukemia L1210 show that the anticancer activity of streptozotocin not only was retained but was enhanced in most of these derivatives.