Abstract: The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.

Abstract: A pressure differential drilling tool and method of underbalanced pressure controlled well bore drilling, characterized by a modulating plug closely expanded to the well bore diameter to form an annulus for external bypass of well fluid immediately above the drill bit and through which the drill string continuously makes hole, and by an upwardly disposed peripheral nozzle jet pump with controlled suction of fluid from the bit so as to establish a reduced and/or underbalanced fluid pressure condition at the bit-to-bore bottom interface for operating the drill bit at an increased rate of penetration while maintaining a higher pressure condition in the well bore annulus above the modulating plug controllably expanded by hydraulic pressure applied to operate the jet pump.

Abstract: A packer and pressure differential drilling tool and method of controlled pressure balanced drilling in Big Hole well bores and shafts, characterized by a large diameter packer slideably engaged with the well bore over a drill bit and through which a dual drill pipe operates and isolates drilling fluid from a hydrostatic head of fluid standing in the well bore surrounding the dual drill pipe, the packer functioning as a non-rotatable ram slideable down the well bore and supporting said hydrostatic head and applying the weight thereof to the drill bit through anti-friction bearings, cuttings being flushed through the dual drill pipe by means of aerated drilling fluid or by an upwardly disposed jet pump, or both, so as to establish a reduced and/or underbalanced condition at the bit-to-bore bottom interface and operating the drill bit at an increased rate of penetration while maintaining a higher pressure condition in the well bore above the packer, the packer being weight set or hydraulic set, and the jet pump