Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: A zero turning radius mower park brake system includes a park brake pawl on a transmission which engages a park brake to a pair of independently driven traction wheels. A park brake link may be pivotably mounted to the park brake pawl and connected to a left steering lever and a right steering lever. The park brake link may pivot while moving the park brake pawl forward to a park brake engaged position if only one of the steering levers is moved outward from a neutral traction drive position.

Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Abstract: This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified ?1-?2 domains of NKG2D ligands.

Abstract: A grow plant enclosure to maximize plant density for a given growing area has a perimeter frame, a first pane, and a second pane. The first pane and the second pane are removably attached to the perimeter frame about opposite sides to form a hollow enclosure. A plurality of plug holder openings traverses through the first pane and the second pane, wherein each of the plug holder openings is designed to receive one of a plurality of plant holders for growing various plant types. A plurality of supply tubes traverse into the perimeter frame through a plurality of supply tube openings and each has a plurality of spray nozzles to deliver nutrient solution to the root zone of the plants retained in the plurality of plant holders. Excess nutrient solution is released through a drain tray and a drain fixture positioned about the bottom of the perimeter frame.

Abstract: This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified ?1-?2 domains of NKG2D ligands.

Abstract: The invention relates to a liquid applied roofing membrane which contains a textile with a compatibility coating covering essentially all of the fibers of the textile forming a coated textile, a first membrane, and a second membrane. The textile contains a plurality of yarns, the yarns comprising a plurality of fibers. The compatibility coating has a weight of between about 0.5 and 10% of the weight of the textile and contains a first chemistry. The first membrane contains a second chemistry and is located on the first side of the textile, forms the lower surface of the roofing membrane, and covers at least a majority of the second side of the textile. The second membrane contains a third chemistry and is located on the second side of the textile. The first, second, and third chemistries comprise the same class of polymeric material.

Abstract: The invention relates to a liquid applied roofing membrane which contains a textile with a compatibility coating covering essentially all of the fibers of the textile forming a coated textile, a first membrane, and a second membrane. The textile contains a plurality of yarns, the yarns comprising a plurality of fibers. The compatibility coating has a weight of between about 0.5 and 10% of the weight of the textile and contains a first chemistry. The first membrane contains a second chemistry and is located on the first side of the textile, forms the lower surface of the roofing membrane, and covers at least a majority of the second side of the textile. The second membrane contains a third chemistry and is located on the second side of the textile. The first, second, and third chemistries comprise the same class of polymeric material.

Abstract: This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified ?1-?2 domains of NKG2D ligands. This application further relates to modified ?1-?2 domains of NKG2D ligands attached to polypeptides, in some embodiments antibodies or fragments of antibodies. This application further relates to antigen-binding peptides derived from light and heavy chain antibody variable domains, which contain two linker regions and a split variable domain.

Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: A scrim reinforced roofing membrane comprising a coated scrim layer having a first side and a second side and a first polyvinyl chloride layer on the first side of the coated scrim layer. The coated scrim layer contains a scrim fabric which contains a plurality of warp yarns in a first direction and a plurality of weft yarns in a second direction approximately perpendicular to the first direction. The warp yarns cross the weft yarns at crossing points. The scrim fabric has a polyvinyl acetate coating which is located along the length of the warp yarns and the weft yarns and between the warp and weft yarns at the crossing points. The coated scrim is at least partially embedded in the first polyvinyl chloride layer.

Abstract: A scrim reinforced roofing membrane comprising a coated scrim layer having a first side and a second side and a first TPO layer on the first side of the coated scrim layer. The coated scrim layer contains a scrim fabric which contains a plurality of warp yarns in a first direction and a plurality of weft yarns in a second direction approximately perpendicular to the first direction. The warp yarns cross the weft yarns at crossing points. The scrim fabric has a polyvinyl acetate coating which is located along the length of the warp yarns and the weft yarns and between the warp and weft yarns at the crossing points. The coated scrim is at least partially embedded in the first TPO layer.

Abstract: A grow plant enclosure to maximize plant density for a given growing area has a perimeter frame, a first pane, and a second pane. The first pane and the second pane are removably attached to the perimeter frame about opposite sides to form a hollow enclosure. A plurality of plug holder openings traverses through the first pane and the second pane, wherein each of the plug holder openings is designed to receive one of a plurality of plant holders for growing various plant types. A plurality of supply tubes traverse into the perimeter frame through a plurality of supply tube openings and each has a plurality of spray nozzles to deliver nutrient solution to the root zone of the plants retained in the plurality of plant holders. Excess nutrient solution is released through a drain tray and a drain fixture positioned about the bottom of the perimeter frame.

Abstract: A grow plant enclosure to maximize plant density for a given growing area has a perimeter frame, a first pane, and a second pane. The first pane is adjacently connected to the perimeter frame, while the second pane is removably attached to the perimeter frame opposite the first pane to form a hollow enclosure. A plurality of plug holder openings traverses through the first pane, and optionally the second pane, being designed to receive a plurality of plant holders for growing various plant types. A plurality of supply tubes traverse into the perimeter frame through a plurality of supply tube openings and each have a plurality of spray nozzles to deliver nutrient solution to the root zone of the plants retained in the plurality of plant holders. Excess nutrient solution is released through a drain fixture positioned about the bottom of the perimeter frame.

Abstract: This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified ?1-?2 domains of NKG2D ligands. This application further relates to modified ?1-?2 domains of NKG2D ligands attached to polypeptides, in some embodiments antibodies or fragments of antibodies. This application further relates to antigen-binding peptides derived from light and heavy chain antibody variable domains, which contain two linker regions and a split variable domain.

Abstract: A grow plant enclosure to maximize plant density for a given growing area has a perimeter frame, a first pane, and a second pane. The first pane is adjacently connected to the perimeter frame, while the second pane is removably attached to the perimeter frame opposite the first pane to form a hollow enclosure. A plurality of plug holder openings traverses through the first pane, and optionally the second pane, being designed to receive a plurality of plant holders for growing various plant types. A plurality of supply tubes traverse into the perimeter frame through a plurality of supply tube openings and each have a plurality of spray nozzles to deliver nutrient solution to the root zone of the plants retained in the plurality of plant holders. Excess nutrient solution is released through a drain fixture positioned about the bottom of the perimeter frame.

Abstract: A scrim reinforced roofing membrane comprising a coated scrim layer having a first side and a second side and a first TPO layer on the first side of the coated scrim layer. The coated scrim layer contains a scrim fabric which contains a plurality of warp yarns in a first direction and a plurality of weft yarns in a second direction approximately perpendicular to the first direction. The warp yarns cross the weft yarns at crossing points. The scrim fabric has a polyvinyl acetate coating which is located along the length of the warp yarns and the weft yarns and between the warp and weft yarns at the crossing points. The coated scrim is at least partially embedded in the first TPO layer.

Abstract: A method for modifying an open-top burner system to a radiant burner system involves providing a stovetop having an open top burner system which includes a grate, burner head, and a venturi burner. The venturi burner includes an open top annular channel about a central opening. Further provided are a central hole plug, an emitter, and a radiant burner head assembly. To modify the stovetop, the grate and burner head are removed from the stovetop and the central plug is used to block airflow through the central opening. The radiant burner head assembly is next positioned over the venturi burner and the emitter is positioned over the radiant burner head assembly. This series of steps thereby converts the assembly from a traditional open-top burner system to a radiant burner system. A kit may be provided to facilitate the process.