Patents by Inventor David W. Mosley
David W. Mosley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110201057Abstract: A method for synthesizing a nucleic acid having a desired sequence and length comprises providing a solid support having an immobilized nucleic acid, performing a nucleic acid addition reaction to elongate the immobilized nucleic acid by adding a nucleotide or an oligonucleotide to the nucleic acid, determining whether the nucleotide or the oligonucleotide is added to the nucleic acid by detecting whether there is an increase in electrophoretic force applied to the solid support when an electric field and a magnetic field gradient are applied to the support, wherein the increase in electrophoretic force applied to the support is caused by adding the nucleotide or the oligonucleotide to the nucleic acid, repeating the addition reaction and determination steps if the nucleotide or the oligonucleotide is not added to the nucleic acid, and continuing until the immobilized nucleic acid has a desired sequence and length.Type: ApplicationFiled: April 25, 2011Publication date: August 18, 2011Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Peter A. Carr, Brian Y. Chow, Joseph M. Jacobson, David W. Mosley, Christopher Emig
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Publication number: 20110124055Abstract: In a method for synthesizing a long nucleic acid molecule, a first immobilized nucleic acid has a first 5? region and a first 3? region and a second immobilized nucleic acid has a second 5? region and a second 3? region, wherein the second 3? region and the first 5? region have identical nucleic acid sequences. The first immobilized nucleic acid is hybridized with an oligonucleotide under conditions promoting hybridization of the oligonucleotide to the first 3? region, extending the hybridized oligonucleotide and producing a first extension product having a 3? region that is complementary to the first 5? region.Type: ApplicationFiled: February 1, 2011Publication date: May 26, 2011Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Peter A. Carr, Brian Y. Chow, Joseph M. Jacobson, David W. Mosley, Christopher Emig
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Publication number: 20110120343Abstract: A Group 3a ink, comprising, as initial components: a polyamine solvent; a Group 3a material/organic complex; and, a reducing agent; wherein the molar concentration of the reducing agent exceeds the molar concentration of the Group 3a material/organic complex; wherein the Group 3a ink is a stable dispersion and wherein the Group 3a ink is hydrazine and hydrazinium free. Also provided are methods of preparing the Group 3a ink and of using the Group 3a ink to deposit a Group 3a material on a substrate for use in a variety of semiconductor applications, such as metallization of silicon devices in VLSI technology, the growth of semiconducting III-V alloys, thin film transistors (TFTs), light emitting diodes (LEDs); and infrared detectors.Type: ApplicationFiled: November 20, 2009Publication date: May 26, 2011Inventors: Kevin Calzia, David W. Mosley
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Patent number: 7932025Abstract: This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of errors within nucleic acid molecules.Type: GrantFiled: December 10, 2003Date of Patent: April 26, 2011Assignee: Massachusetts Institute of TechnologyInventors: Peter A. Carr, Brian Y. Chow, Joseph M. Jacobson, David W. Mosley, Christopher Emig
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Publication number: 20110076799Abstract: A selenium/Group 1b ink comprising, as initial components: a selenium component comprising selenium, an organic chalcogenide component having a formula selected from RZ—Z?R? and R2—SH, a Group 1b component and a liquid carrier; wherein Z and Z? are each independently selected from sulfur, selenium and tellurium; wherein R is selected from H, C1-20 alkyl group, a C6-20 aryl group, a C1-20 alkylhydroxy group, an arylether group and an alkylether group; wherein R? and R2 are selected from a C1-20 alkyl group, a C6-20 aryl group, a C1-20 alkylhydroxy group, an arylether group and an alkylether group; and wherein the selenium/Group 1b ink is a stable dispersion.Type: ApplicationFiled: September 28, 2009Publication date: March 31, 2011Applicant: ROHM AND HAAS ELECTRONIC MATERIALS LLCInventors: Kevin Calzia, David W. Mosley, Charles R. Szmanda, David L. Thorsen
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Publication number: 20110076798Abstract: A selenium ink comprising, as initial components: a liquid carrier; a selenium component comprising selenium; and, an organic chalcogenide component having a formula selected from RZ—Z?R? and R2—SH, a Group 1b component and a liquid carrier; wherein Z and Z? are each independently selected from sulfur, selenium and tellurium; wherein R is selected from H, C1-20 alkyl group, a C6-20 aryl group, a C1-20 alkylhydroxy group, an arylether group and an alkylether group; wherein R? and R2 are selected from a C1-20 alkyl group, a C6-20 aryl group, a C1-20 alkylhydroxy group, an arylether group and an alkylether group; wherein the selenium ink comprises ?1 wt % selenium; wherein the selenium ink is a stable dispersion and wherein the selenium ink is hydrazine and hydrazinium free.Type: ApplicationFiled: September 28, 2009Publication date: March 31, 2011Applicant: ROHM AND HAAS ELECTRONIC MATERIALS LLCInventors: Kevin Calzia, David W. Mosley, Charles R. Szmanda, David L. Thorsen
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Patent number: 7879580Abstract: This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of errors within nucleic acid molecules.Type: GrantFiled: December 10, 2003Date of Patent: February 1, 2011Assignee: Massachusetts Institute of TechnologyInventors: Peter A. Carr, Brian Y. Chow, Joseph M. Jacobson, David W. Mosley, Christopher Emig
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Publication number: 20090326269Abstract: A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed.Type: ApplicationFiled: July 19, 2009Publication date: December 31, 2009Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Joseph M. Jacobson, David W. Mosley
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Patent number: 7563482Abstract: A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed.Type: GrantFiled: December 24, 2007Date of Patent: July 21, 2009Assignee: Massachusetts Institute of TechnologyInventors: Joseph M. Jacobson, David W. Mosley
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Publication number: 20090124780Abstract: Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles.Type: ApplicationFiled: January 12, 2009Publication date: May 14, 2009Applicant: Massachusetts Institute of TechnologyInventors: Joseph M. Jacobson, David W. Mosley, Kie-Moon Sung
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Patent number: 7476442Abstract: Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles.Type: GrantFiled: July 17, 2003Date of Patent: January 13, 2009Assignee: Massachusetts Institute of TechnologyInventors: Joseph M. Jacobson, David W. Mosley, Kie-Moon Sung
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Publication number: 20080118644Abstract: A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed.Type: ApplicationFiled: December 24, 2007Publication date: May 22, 2008Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Joseph M. JACOBSON, David W. MOSLEY
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Patent number: 7311943Abstract: A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers may be used as templates for the growth of inorganic colloids. A preferred embodiment is a SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. Once the second monolayer has formed, it is polymerized in place and the two monolayers are separated to form a replicate. Both monolayers may then function as templates for monolayer assemblies. A generic self-replicating monomer unit suitable for use in one embodiment comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry.Type: GrantFiled: July 17, 2003Date of Patent: December 25, 2007Assignee: Massachusetts Institute of TechnologyInventors: Joseph M. Jacobson, David W. Mosley
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Publication number: 20040264263Abstract: This invention generally relates to solution-based molecular shuttle devices. More particularly, this invention relates to solution-based molecular switches, molecular assemblies, and molecular memory devices and methods for producing the same. In some embodiments the devices are made from molecular chains constructed from molecular subunits which define binding positions and shuttles that are capable of moving along the chains.Type: ApplicationFiled: July 17, 2003Publication date: December 30, 2004Applicant: ASSIGNEE-COMPANY-NAMEInventors: Joseph M. Jacobson, David W. Mosley, Brian Chow
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Publication number: 20040077844Abstract: Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles.Type: ApplicationFiled: July 17, 2003Publication date: April 22, 2004Inventors: Joseph M. Jacobson, David W. Mosley, Kie-Moon Sung
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Publication number: 20040076757Abstract: A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers may be used as templates for the growth of inorganic colloids. A preferred embodiment is a SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. Once the second monolayer has formed, it is polymerized in place and the two monolayers are separated to form a replicate. Both monolayers may then function as templates for monolayer assemblies. A generic self-replicating monomer unit suitable for use in one embodiment comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry.Type: ApplicationFiled: July 17, 2003Publication date: April 22, 2004Inventors: Joseph M. Jacobson, David W. Mosley