Abstract: A video game-based medical simulation is provided. Disclosed embodiments pertain to mass-casualty simulation for burn disaster training. Game-play exercises direct a player through a mass-casualty event where triage management and patient assessment are tested, and then follow the player to a Burn Center where resuscitation through patient monitoring, reassessment, and managing are tested for the critical hours/days of recovery. Complication loops are included in the game system to provide random application of variation in patient response. The complication loops can insert semi-randomness of critical complication occurrences into the game such that patient simulation may vary each time the game is played.