Patents by Inventor David W. Rasnick

David W. Rasnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
    Patent number: 6358928
    Abstract: Novel &agr;-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing &agr;-amino and peptidyl sulfonyl imidazolides and their use in the treatment of disease states characterized by an over-activity of serine proteases are also disclosed. Novel synthetic methods for the synthesis of sulfonyl derivatives, particularly &agr;-amino and peptidyl sulfonyl derivatives, from thioic acid S-esters are also disclosed.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: March 19, 2002
    Assignee: Enzyme Systems Products
    Inventor: David W. Rasnick
  • Method of detecting cysteine proteases
    Patent number: 4908309
    Abstract: Peptide thioneamides are provided as synthetic substrates for cysteine proteases. The compounds of the invention are peptides consisting of one or more blocked or unblocked amino acids wherein the terminal carboxy of the peptides are thionated and forms a thioneamide linkage with a fluorogenic or chromogenic leaving group. The alpha carbonyls of the remaining amino acids are thionated or unthionated. The invention includes methods and kits for using the peptide thioneamides.
    Type: Grant
    Filed: September 8, 1987
    Date of Patent: March 13, 1990
    Assignee: Prototek, Inc.
    Inventors: Kyujin Cho, David W. Rasnick
  • Peptide thioneamides as selective substrates for cysteine proteases
    Patent number: 4771123
    Abstract: Peptide thioneamides are provided as synthetic substrates for cysteine proteases. The compounds of the invention are peptides consisting of one or more blocked or unblocked amino acids wherein the terminal carboxy of the peptides are thionated and forms a thioneamide linkage with a fluorogenic or chromogenic leaving group. The alpha conbonyls of the remaining amino acids are thionated or unthionated. The invention includes methods and kits for using the peptide thioneamides.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: September 13, 1988
    Assignee: Enzyme Systems Products, Inc.
    Inventors: Kyujin Cho, David W. Rasnick
  • .alpha. Amino fluoro ketones
    Patent number: 4518528
    Abstract: Novel .alpha. amino fluoro ketones, a method of their synthesis and a method for irreversibly inhibiting proteases is disclosed.
    Type: Grant
    Filed: February 6, 1984
    Date of Patent: May 21, 1985
    Inventor: David W. Rasnick
  • 7-Amino-4-trifluoromethylquinolone derived substrates and method for determining enzymes and inhibitors
    Patent number: 4505852
    Abstract: Substrates and their corresponding pharmaceutically acceptable acid salts derived from 7-amino-4-trifluoromethyl-quinolone are disclosed. These substrates are useful for determining the presence of an enzyme or enzyme inhibitor in a biological fluid, wherein the fluid is contacted with a substrate. This mixture is thereafter incubated to effect enzymatic hydrolysis. Subsequently, the presence of the free 7-amino-4-trifluoro-methylquinolone is fluorometrically detected.
    Type: Grant
    Filed: November 29, 1982
    Date of Patent: March 19, 1985
    Assignee: Enzyme Systems Products
    Inventors: David W. Rasnick, Eugene R. Bissell