Patents by Inventor David W. Rodgers

David W. Rodgers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant insulin degrading enzyme and methods of use
    Patent number: 8632989
    Abstract: In one aspect, the present invention provides an isolated mutant insulin degrading enzyme (IDE) having an amino acid sequence that is at least 90% identical to SEQ ID NO:1 over its entire length and comprises at least one amino acid substitution at any of amino acid residues 332, 339, 341, 359, 360, 361, 374, 429, 609, 898, 899 or 901 of the sequence. The mutant IDE has a differential activity relative to that of wild-type IDE. Also provided is a polynucleotide encoding the polypeptide of the invention.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: January 21, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: David W. Rodgers, Louis B. Hersh, Nicholas Noinaj, Eun Suk Song
  • Crystallization and structure of a plant peptide deformylase
    Patent number: 7445923
    Abstract: This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: November 4, 2008
    Assignee: University of Kentucky Research Foundation
    Inventors: Robert L. Houtz, David W. Rodgers, Lynette M. A. Dirk, Mark A. Williams