Abstract: A modular flow monitoring package (MFMP) is provided for use in an additive delivery system. The MFMP may be manufactured as an add-on to be added to an existing additive delivery system, or may be incorporated into a cartridge or container structure. The MFMP includes a flow sensor for sensing flow of a base fluid and user actuator position sensors for sensing the position of one or more user actuated additive flow adjustment levers. A visual display, which may comprise an array of multi-color LED's may convey information to a user that is relevant to a user's use of the additive delivery system or the user's nutritional needs. Such information may include a current dosage of additive, being delivered, whether a recommended dosage of additive has been consumed, remaining life of a cartridge or supply of additive, and other data relative to health or performance monitoring.

Abstract: A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.

Abstract: The present invention is directed to compositions comprising a substantially non-antigenic carrier associated with an antigen and the use of such compositions to enhance the immunogenicity of the associated antigen. In addition, the compositions of the invention may be used to generate an immune response directed predominantly to an antigen associated with a carrier. Specific carriers of the invention include homopolymers and copolymers of polyamino acids. Compositions of the invention are used according to the invention to elicit or enhance an immune response directed against an antigen and may be used for the prevention and treatment of infection and disease, for example. Additionally, compositions of the invention are useful for generating an antibodies specific for an antigen and, accordingly, may be used to generate antigen-specific antibodies suitable for the diagnosis or treatment of infection and disease.

Abstract: A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.