Abstract: The disclosed technology concerns a method for wetting and dispersing a pulverulent polycarboxylic acid containing polymer in aqueous media without the need of a steric stabilizer and/or a wetting agent, said method comprises a) providing a pulverulent pre-neutralized carboxylic acid containing polymer or copolymer, wherein said polymer or copolymer is prepared from a monomer mixture comprising at least one olefinically unsaturated carboxylic acid group containing monomer, and wherein from about 1 to about 10 wt. % of said carboxylic acid group containing monomer(s) is neutralized; b) mixing said pulverulent pre-neutralized carboxylic acid containing polymer or copolymer in aqueous medium; and c) mixing a deswelling agent selected from an acid, a salt, and combinations thereof with said aqueous medium, and optionally d), adjusting the pH.

Abstract: An amorphous solid dispersion includes a linear poly(acrylic acid) and an active pharmaceutical ingredient. The linear poly(acrylic acid) used to form the amorphous solid dispersion has a Brookfield viscosity of at least 100 cP at 25° C. A method of forming such an amorphous solid dispersion of an active pharmaceutical ingredient includes forming a liquid dispersion of a linear poly(acrylic acid), an active pharmaceutical ingredient, and a solvent system, the linear poly(acrylic acid) having a Brookfield viscosity at 25° C. of at least 100 cP and evaporating the solvent system from the liquid dispersion to form an amorphous solid dispersion.