Patents by Inventor David Waller

David Waller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10457692
    Abstract: The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: October 29, 2019
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, David Waller, Hwan Guen Choi, Jinhua Wang, Xianming Deng
  • Publication number: 20190263831
    Abstract: Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.
    Type: Application
    Filed: November 6, 2018
    Publication date: August 29, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: David Waller, Gregory Gazda, Zachary Minden, Lisa Barton, Clifton Leigh
  • Publication number: 20190084998
    Abstract: The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
    Type: Application
    Filed: November 20, 2018
    Publication date: March 21, 2019
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, David Waller, Hwan Guen Choi, Jinhua Wang, Xianming Deng
  • Patent number: 10189861
    Abstract: The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: January 29, 2019
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, David Waller, Hwan Guen Choi, Jinhua Wang, Xianming Deng
  • Patent number: 10189017
    Abstract: Ho Honeycomb monolith structure, especially for use in mass transfer-limited processes or processes for the selective catalytic reduction (SCR) of nitrogen oxides, comprising: a plurality of cell walls defining a plurality of polygonal channels, the plurality of cell walls and channels extending in parallel along a common direction from an entrance end to an outlet end of the structure in the fluid flow direction. The transversal cross section of a polygonal channel has the shape of a convex elongated polygon, wherein at least 50% of the internal angles between two adjacent walls of the convex polygon are above 90 degrees and wherein the cell diameter ratio LL/LS is greater than 1.5.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: January 29, 2019
    Assignee: YARA INTERNATIONAL ASA
    Inventors: David Waller, Karl Isak Skau, Sang Baek Shin, Bent Erlend Vigeland
  • Patent number: 10125149
    Abstract: Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: November 13, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: David Waller, Gregory Gazda, Zachary Minden, Lisa Barton, Clifton Leigh
  • Publication number: 20170334721
    Abstract: The present invention provides a catalyst for production of nitric oxide from ammonia and oxygen. The catalyst has the composition A3-xBxO9-y, wherein A and B are selected from the group Mn, Co, Cr, Fe and Al, x is between 0 and 3 and y is between 0 and 6. The catalyst has a high selectivity towards nitric oxide and a low ignition temperature in the reactor. Further the present invention relates to a method for the production of gas comprising nitric oxide by the catalyst of the present invention. The produced gas has a low content of nitrous oxide.
    Type: Application
    Filed: June 30, 2017
    Publication date: November 23, 2017
    Inventor: David Waller
  • Publication number: 20170283422
    Abstract: The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
    Type: Application
    Filed: April 28, 2017
    Publication date: October 5, 2017
    Inventors: Nathanael S. Gray, David Waller, Hwan Guen Chio, Jinhua Wang, Xianming Deng
  • Publication number: 20170275300
    Abstract: Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof.
    Type: Application
    Filed: August 14, 2015
    Publication date: September 28, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: David Waller, Gregory Gazda, Zachary Minden, Lisa Barton, Clifton Leigh
  • Patent number: 9725319
    Abstract: The present invention provides a catalyst for production of nitric oxide from ammonia and oxygen. The catalyst has the composition A3-xBxO9-y, wherein A and B are selected from the group Mn, Co, Cr, Fe and Al, x is between 0 and 3 and y is between 0 and 6. The catalyst has a high selectivity towards nitric oxide and a low ignition temperature in the reactor. Further the present invention relates to a method for the production of gas comprising nitric oxide by the catalyst of the present invention. The produced gas has a low content of nitrous oxide.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 8, 2017
    Assignee: YARA INTERNATIONAL ASA
    Inventor: David Waller
  • Patent number: 9675963
    Abstract: The present invention relates to a catalytically active component of a catalyst, which comprises single phase oxides, based on a mixed yttrium-gadolinium ortho-cobaltate oxide systems, methods for the oxidation of ammonia and hydrocarbon in the presence of said catalytically active component and the use thereof.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: June 13, 2017
    Assignee: YARA INTERNATIONAL ASA
    Inventors: David Waller, Marianne Søbye Grønvold, Nibal Sahli
  • Patent number: 9676792
    Abstract: The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: June 13, 2017
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Nathanael S. Gray, David Waller, Hwan Guen Choi, Jinhua Wang, Xianming Deng
  • Patent number: 9616413
    Abstract: The present invention provides a catalyst for production of nitric oxide from ammonia and oxygen. The catalyst has the composition A((n+1)?x)BxC(n(1?y))DnyO(3n+1)+d, wherein A is a lanthanide (La, Gd, Nd, Sm) or yttrium, B is an alkaline-earth cation (Ca, Sr or Ba), C is Fe and D is Cr, Mn, Ni, Ce, Ti, Co or Mg, wherein A, B, C and D are selected independent of each other. The catalyst has a high selectivity towards nitric oxide and a low ignition temperature in the reactor. Further the present invention relates to a method for the production of gas comprising nitric oxide by the catalyst of the present invention. The produced gas has a very low content of nitrous oxide.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: April 11, 2017
    Assignee: YARA INTERNATIONAL ASA
    Inventor: David Waller
  • Patent number: 9403681
    Abstract: The present invention relates to a catalytically active component of a catalyst, which comprises single phase oxides, based on a metal doped yttrium ortho-cobaltate oxide systems, methods for the oxidation of ammonia 5 and hydrocarbon in the presence of said catalytically active component and the use thereof.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: August 2, 2016
    Assignee: YARA INTERNATIONAL ASA
    Inventors: David Waller, Marianne Søbye Grønvold, Nibal Sahli
  • Patent number: 9337358
    Abstract: Benzodithiophene-containing polymers, as well as related photovoltaic cells, articles, systems, and methods, are disclosed.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: May 10, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Paul Byrne, Kap-Soo Cheon, Gilles Dennler, Nicolas Drolet, Serge Thompson, David Waller, Li Wen
  • Publication number: 20160024115
    Abstract: The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Nathanael S. Gray, David Waller, Hwan Guen Choi, Jinhua Wang, Xianming Deng
  • Publication number: 20150367330
    Abstract: The present invention relates to a catalytically active component of a catalyst, which comprises single phase oxides, based on a mixed yttrium-gadolinium ortho-cobaltate oxide systems, methods for the oxidation of ammonia and hydrocarbon in the presence of said catalytically active component and the use thereof.
    Type: Application
    Filed: January 24, 2014
    Publication date: December 24, 2015
    Inventors: David WALLER, Marianneø Søbye GRØNVOLD, Nibal SAHLI
  • Publication number: 20150353356
    Abstract: The present invention relates to a catalytically active component of a catalyst, which comprises single phase oxides, based on a metal doped yttrium ortho-cobaltate oxide systems, methods for the oxidation of ammonia 5 and hydrocarbon in the presence of said catalytically active component and the use thereof.
    Type: Application
    Filed: January 24, 2014
    Publication date: December 10, 2015
    Inventors: David WALLER, Marianne Søbye GRØNVOLD, Nibal SAHLI
  • Publication number: 20150336094
    Abstract: Ho Honeycomb monolith structure, especially for use in mass transfer-limited processes or processes for the selective catalytic reduction (SCR) of nitrogen oxides, comprising: a plurality of cell walls defining a plurality of polygonal channels, the plurality of cell walls and channels extending in parallel along a common direction from an entrance end to an outlet end of the structure in the fluid flow direction. The transversal cross section of a polygonal channel has the shape of a convex elongated polygon, wherein at least 50% of the internal angles between two adjacent walls of the convex polygon are above 90 degrees and wherein the cell diameter ratio LL/LS is greater than 1.5.
    Type: Application
    Filed: January 24, 2014
    Publication date: November 26, 2015
    Inventors: David WALLER, Karl Isak SKAU, Sang Baek SHIN, Bent Erlend VIGELAND
  • Patent number: 9123895
    Abstract: Photovoltaic cells with thiazole-containing polymers, as well as related components, systems, and methods, are disclosed.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: September 1, 2015
    Assignee: Merck Patent GmbH
    Inventors: Russell Gaudiana, Richard Kingsborough, Xiaobo Shi, David Waller, Zhengguo Zhu