Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.

Abstract: The present disclosure relates to methods and systems for automatically providing a suggestion to delay sending a message that is being composed by a user to send to a chat participant using a chat feature of an application. The suggestion is sent in response to determining that one or more trigger conditions occurred. The suggestion includes a scheduled time to send the message. The methods and systems send the delayed message at the scheduled time.

Abstract: In one aspect, a liquid collector having a forward lower edge, a connecting wall portion extending downwardly from the forward edge, a first layback wall portion connected to the connecting wall portion and extending upwardly and rearwardly from the connecting wall portion, an intermediate upper edge of the layback wall portion rearward of and above the forward lower edge. The liquid collector further includes an air diverter wall portion extending rearwardly from the first layback wall portion below the intermediate upper edge, a second layback wall portion extending upwardly and rearwardly of the air diverter wall portion, and a rearward upper edge of the second layback wall portion rearward of the intermediate upper edge and above the forward lower edge.

Abstract: Guardrail, guardrail terminal, and support post designs that improve control of a vehicle during collisions are described. The disclosed designs also reduce the likelihood of intrusion into vehicle systems and the occupant compartment(s). Embodiments include folding and/or flattening of the guardrail and controlling the folded and flattened guardrail to avoid intrusion into the vehicle. Other embodiments include containing the guardrail in an impact head of a guardrail terminal, which also avoids vehicle intrusion.

Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.

Abstract: In one aspect, a heat exchange apparatus is disclosed having a liquid distribution system configured to distribute liquid onto a liquid absorbent material and an airflow generator operable to cause air to flow through the liquid absorbent material and toward an indirect heat exchanger. The heat exchange apparatus includes a controller configured to operate in a dry mode where the controller inhibits the liquid distribution system from distributing liquid onto the liquid absorbent material and a wet mode where the controller causes the liquid distribution system to distribute liquid onto the liquid absorbent material. The controller is further configured to operate at least one of the liquid distribution system and the airflow generator to inhibit drift of liquid from the liquid absorbent material toward the indirect heat exchanger in response to the controller switching from the dry mode to the wet mode.

Abstract: A method to control a marine vessel comprising two or more drive units. The method involves registering an operating command indicating a requested sideways or bow bollard push function; detecting a current vessel position; registering the current vessel position as a desired vessel position; executing the requested bollard push function; and monitoring the current vessel position in order to detect a deviation relative to the desired vessel position. If it is detected that a deviation between the desired vessel position has exceeded a predetermined value, then the requested bollard push function is deactivated. The disclosure further relates to a control unit arranged to control a marine vessel and a marine vessel comprising such a control unit.

Abstract: The disclosure relates to a method and a control unit to control a marine vessel comprising two or more drive units. The method involving the steps of registering an operating command indicating a requested vessel direction and plotting a course represented by a reference line for the requested vessel direction from an initial position. It is then monitored if the vessel has deviated from the reference line and if a deviation from the reference line is detected, then a value for current vessel speed is detected. The detected vessel speed value is compared to a predetermined reference speed value to determine if the current vessel speed value is within a high speed interval or a low speed interval relative to the reference speed value. Depending on the determined speed interval the vessel is controlled according a low speed control strategy; or a high speed control strategy in order to move the vessel from a current vessel heading to the reference line and the requested vessel direction.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy

Abstract: The present invention is directed to pyridyl derivatives which are bromodomain inhibitors, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases or conditions.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The present disclosure is directed to methods and systems for processing replacements to a target array by a plurality of source arrays. Selected tokens in a target array may be replaced with corresponding tokens from a source array to generate a region of identical tokens, which may be processed or removed. Tokens in the target array may be shifted in a direction corresponding to the source array to fill empty cells within the target array and new tokens generated. Selections may be made from multiple source arrays iteratively, with shift directions dynamically modified.