Abstract: A 3D printing apparatus and method prints a partial part, and continues to print the part after the partially-printed part has been rotated. Each partial printing operation may include reinforcement via application of one or more layers of continuous fiber. The rotation and continued printing of the partially-printed part allows for fiber orientation in different orientations for the printed part.

Abstract: An apparatus includes a base and a robotic arm operatively coupled to the base via a connector. The robotic arm includes a set of links interconnected by a set of joints. A first link from the set of links is operatively coupled to the connector. Each joint from the set of joints includes a brake from a set of brakes, each brake from the set of brakes configured to be enabled or disabled. The apparatus further comprises an end effector operatively coupled to the robotic arm via a second link from the set of links different from the first link. The apparatus further comprises a controller, communicably coupled to at least one of the base, the robotic arm, or the end effector. The controller is configured to cause the robotic arm to perform a task, and determine, during the task, that movement of the robotic arm is to be restricted.

Abstract: An electronic gaming device includes a display device and a game controller in communication with the display device. The game controller includes a processor and a memory storing instructions, which when executed by the processor, cause the game controller to: cause display of a base game including a plurality of reels; control the plurality of reels to display a combination of symbols corresponding to a primary game outcome; determine that the primary game outcome satisfies a bonus game condition and an enhancement condition to trigger a bonus game having at least one enhanced characteristic; identify outcomes for one or more free spins of the bonus game having the at least one enhanced characteristic; randomly select an outcome for each free spin from the identified outcomes; and initiate the bonus reel game that includes display of the randomly selected outcome for each of the one or more free spins.

Abstract: A vehicle assembly includes a cargo bed having a first and a second sidewall. A rail assembly is disposed on the first sidewall. The rail assembly is movable between an extended position and a retracted position relative to the first sidewall. An actuator system raises and lowers the rail assembly to move the rail assembly between the extended position and the retracted position.

Abstract: Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LMVGG [SEQ ID NO: 3] sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases.

Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Abstract: An in vitro tissue plate may include a well plate, a fluidic plate disposed on a bottom surface of the well plate, and a media manifold disposed on a bottom surface of the fluidic plate. The well plate may have at least two wells, including a tissue well and a waste well. The fluid plate may include a fluid channel extending between and fluidly connecting the tissue well to the waste well. The media manifold may include a one or more media outlets fluidly connected to the fluid channel. A tissue layer may be deposited in the tissue well. The tissue layer may include human cells such as neurovascular cells.

Abstract: The disclosed computer-implemented methods may include detecting malicious usage based on a user's behavior in connection with a wearable computing device. Similarly, another method may detect a bystander within range of a sensor, in which the device may determine if capturing information associated with a bystander is authorized. Another method may also include performing a segmentation of the media content and detecting a privacy portion of the media content. Furthermore, a method may include identifying a set of image frames and designating an optimal frame for storing. Additionally, a method may include a visibility-based subscription for video streams to determine a subset of the registered participant tiles to be subscribed to and displayed via the display device. Lastly, a system may include a processor that detects the difference of mutual capacitance between a first and second wire. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: An intervertebral spacer assembly may include a first intervertebral spacer with a superior surface configured to engage a superior vertebral body, an inferior surface configured to engage an inferior vertebral body, and a proximal surface with a first fastener channel. The assembly may further include a first fastener and a locking member with a first anti-backout member. The first intervertebral spacer or the locking member may have a locking member channel. The other may have a compressible collet insertable into the locking member channel to couple the locking member to the first intervertebral spacer such that the locking member is rotatable relative to the first intervertebral spacer between an unlocked position in which the first anti-backout member does not obstruct the first fastener channel, and a locked position in which the first anti-backout member obstructs the first fastener channel to retain the first fastener in the first fastener channel.

Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Abstract: Circuits that employ selective solid-state isolation of circuit elements can include solid-state switches, such as back-to-back Field Effect Transistor (FET) pairs, and isolated gate drive electronics adapted to operate the solid-state switches in order to selectively decouple certain circuit elements. The isolated solid-state switches can be placed in series to achieve higher standoff voltages, and can be configured for low on resistance and short switching times. The gate drive electronics can include electrical isolation components adapted to enhance standoff voltages and reduce electrical noise at the selectively isolated circuit elements.

Abstract: Switched gradient field measurement techniques for SNMR are disclosed, as well as hardware and software that implements the disclosed techniques. The disclosed techniques allow directly imaging groundwater and hydrogeologic parameters at high resolution in the near subsurface. The resulting technology redefines practical capabilities for hydrogeologic imaging and shallow groundwater mapping, ultimately improving our ability understand, manage, and respond to critical zone processes.

Abstract: A grill brush includes a brush head with brush-head upper and lower surfaces, the brush-head lower surface having a plurality of bristles protruding therefrom. An elongated handle extends between handle proximate and distal ends. The handle distal end is defined in part by a brush-head mount including a mounting surface configured to retain the brush-head upper surface. A grill-cleaning implement plate is situated at least partially between the brush-head upper surface and the brush-head mount and extends longitudinally between plate back and front ends. At least one of the plate back and front ends has depending therefrom a grate-cleaning implement. The implement plate is rotatably retained between the brush-head upper surface and the brush-head mount such that, with the brush head stationary relative to the brush handle, the implement plate can be rotated with respect to the brush handle and brush head between mutually opposed first and second angular orientations.

Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

Abstract: Systems and methods to account for uncertainties from missing covariates in generative model predictions. One embodiment includes a method for updating the values for uncertainty used in a generative model that is created using a set of known prognostically important baseline data. The method includes steps for determining a value, within the generative model, for the variance in outcome given the known prognostically important baseline data, wherein the steps include imputing values for a set of unknown prognostically important baseline data, and determining estimations for explained and unexplained variance in outcome for each subject when given both sets of data.

Abstract: Systems and methods for designing random control trials in accordance with embodiments of the invention are illustrated. One embodiment includes a method for designing a target random control trial. The method includes steps for generating a set of prognostic scores for a set of samples, computing a first correlation between the set of prognostic scores and a set of outcomes for the set of samples, computing a first variance for the set of outcomes for the set of samples, estimating a second correlation and a second variance for a target random control trial, and determining a set of target trial parameters based on the first and second correlations and the first and second variances.

Abstract: An insertion assembly may include a DTS guide and an inserter tool configured to couple an intervertebral spacer having a fastener channel configured to receive a fastener and a locking member channel with a first engagement feature. The inserter tool may include a second engagement feature configured to engage the first engagement feature and removably couple the inserter tool with the intervertebral spacer. The DTS guide may include a shaft lumen configured to receive the inserter tool and slidably couple with the inserter tool. The DTS guide may also include a DTS guide channel configured to receive the fastener and a DTS guide wing. The DTS guide wing may abut against a surface of the intervertebral spacer to align the DTS guide channel with the fastener channel and guide the fastener through the DTS guide channel and into the fastener channel.

Abstract: An insertion assembly may include a flexible tool and a DTS guide configured to engage an intervertebral spacer having a fastener channel oriented at a first angle. The DTS guide may include a DTS guide channel oriented at the first angle which may be aligned with the fastener channel. The flexible tool may include a flexible shaft and a working member disposed at a distal end of the flexible shaft. The working member may be received through the DTS guide channel at the first angle. At least a portion of the flexible shaft adjacent the DTS guide member may flex while the working member is received through the DTS guide channel, such that a distal portion of the flexible shaft may be at a greater absolute angle relative to a DTS guide shaft than a proximal portion of the flexible shaft.

Abstract: An intervertebral spacer assembly may include a first intervertebral spacer with a superior surface configured to engage a superior vertebral body, an inferior surface configured to engage an inferior vertebral body, and a proximal surface with a first fastener channel. The assembly may further include a first fastener and a locking member with a first anti-backout member. The first intervertebral spacer or the locking member may have a locking member channel. The other may have a compressible collet insertable into the locking member channel to couple the locking member to the first intervertebral spacer such that the locking member is rotatable relative to the first intervertebral spacer between an unlocked position in which the first anti-backout member does not obstruct the first fastener channel, and a locked position in which the first anti-backout member obstructs the first fastener channel to retain the first fastener in the first fastener channel.