Patents by Inventor David Walsh

David Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210062128
    Abstract: An in vitro tissue plate may include a well plate, a fluidic plate disposed on a bottom surface of the well plate, and a media manifold disposed on a bottom surface of the fluidic plate. The well plate may have at least two wells, including a tissue well and a waste well. The fluid plate may include a fluid channel extending between and fluidly connecting the tissue well to the waste well. The media manifold may include a one or more media outlets fluidly connected to the fluid channel. A tissue layer may be deposited in the tissue well. The tissue layer may include human cells such as neurovascular cells.
    Type: Application
    Filed: June 26, 2020
    Publication date: March 4, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Johanna Bobrow, Todd Thorsen, David Walsh, Christina Zook
  • Publication number: 20200369592
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Publication number: 20200345399
    Abstract: A modular system is provided for assembling a structure to secure to opposite sides of a fracture in a bone of a subject. The modular system includes a plate with a perimeter including a plurality of openings. The perimeter defines an interior area within the plate. The modular system also includes a link with one or more openings along a linear axis defining the link. The one or more openings of the link include a connector to receive a fastener to be secured in the bone. The plurality of openings of the plate includes a first opening with an inner diameter configured to removably receive an outer diameter of the connector of the link so that the link is rotatably received within the first opening. A method is also provided for assembling the structure using the modular system and securing the assembled structure to opposite sides of the bone fracture.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Richard O. GREGORY, II, David A. WALSH, Mark Schumacher
  • Patent number: 10774027
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 15, 2020
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Patent number: 10679141
    Abstract: An identity and access management IAM system is augmented to provide for supervised, iterative machine learning (ML), preferably with a user-generated training set for classification. The training set may include various types of data, including characteristics or attributes of the account types, the users, or the like. A goal of the initial ML training, which may include one or multiple passes, is to enable the machine to identify specific characteristics or attributes that provide a good classification result, with the resulting classifications then applied within the IAM system. In particular, the output of the ML system may be used by the IAM system for enforcing rights associated with the identified accounts, managing accounts, and so forth.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 9, 2020
    Assignee: International Business Machines Corporation
    Inventors: Brian Robert Matthiesen, Gee Ngoo Chia, John Leslie Harter, David Walsh Palmieri
  • Patent number: 10640481
    Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: May 5, 2020
    Assignee: Lung Biotechnology PBC
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
  • Patent number: 10548863
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 4, 2020
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Publication number: 20200030271
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: October 7, 2019
    Publication date: January 30, 2020
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • Patent number: 10478410
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: November 19, 2019
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Publication number: 20190233362
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Publication number: 20190202797
    Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
    Type: Application
    Filed: March 11, 2019
    Publication date: July 4, 2019
    Applicant: Lung Biotechnology PBC
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
  • Patent number: 10322099
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: June 18, 2019
    Assignee: UNITED THERAPEUTICS CORPORATION
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Patent number: 10246430
    Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: April 2, 2019
    Assignee: Lung Biotechnology PBC
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
  • Patent number: 10196342
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: February 5, 2019
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Publication number: 20180265490
    Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
    Type: Application
    Filed: May 4, 2018
    Publication date: September 20, 2018
    Applicant: Lung Biotechnology PBC
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Tummala, Raju Penmasta, David A. Walsh
  • Patent number: 10005753
    Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: June 26, 2018
    Assignee: Lung Biotechnology PBC
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
  • Patent number: 9998607
    Abstract: A method of provisioning a plurality of applications from different application developer systems to a network provider system comprises establishing a plurality of service accounts for a corresponding plurality of application service provider systems, receiving a plurality of API interfaces from the plurality of application service provider systems, integrating, by the processor system, each of the plurality of API interfaces with a unified services platform API interface, receiving a provider API interfaces for a network provider system, and integrating the provider API interface with the unified services platform API interface. The plurality of application service provider systems provide services for use in association with a telephone number of a subscriber of telecommunication services. At least two of the API interfaces are different, and at least one of the plurality of API interfaces from the plurality of application service provider systems is not compatible with the provider API interface.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: June 12, 2018
    Assignee: Zilkr Cloud Technologies, LLC
    Inventors: Evin A. Hunt, John Abraham, David Walsh, Carlos Ortiz, Chris Murphy
  • Patent number: 9942261
    Abstract: An identity and access management (IAM) system is associated with a set of data sources from which data is collected. A set of vulnerabilities that the IAM system should attempt to detect is identified. For each vulnerability to be detected, a prioritized list of strategies used to detect that vulnerability is generated. Preferably, each strategy specifies the type(s) of data required to detect that vulnerability. An algorithm to determine a best strategy to be used for detecting each vulnerability, preferably based on the data available from the data sources, is then identified. The IAM system then collects data in an optimized manner. In particular, during the collection process, the IAM system preferably collects only what is necessary based on the configuration, even if the data source is capable of providing additional data. The collected data is then processed to detect security vulnerabilities associated with the IAM accounts.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 10, 2018
    Assignee: International Business Machines Corporation
    Inventors: John Leslie Harter, David Walsh Palmieri, Jeffrey Tobias Robke
  • Publication number: 20170285685
    Abstract: A heat sink for electronic devices, such as wearable displays, dissipates heat away from and electrical component, such as a microprocessor. An adjustable support assembly permits adjustment of a visual display relative to a user's field of view.
    Type: Application
    Filed: April 4, 2017
    Publication date: October 5, 2017
    Inventors: Guy A. Mascaro, Mark Gamache, Matthew David Walsh
  • Publication number: 20170195360
    Abstract: An identity and access management (IAM) system is associated with a set of data sources from which data is collected. A set of vulnerabilities that the IAM system should attempt to detect is identified. For each vulnerability to be detected, a prioritized list of strategies used to detect that vulnerability is generated. Preferably, each strategy specifies the type(s) of data required to detect that vulnerability. An algorithm to determine a best strategy to be used for detecting each vulnerability, preferably based on the data available from the data sources, is then identified. The IAM system then collects data in an optimized manner. In particular, during the collection process, the IAM system preferably collects only what is necessary based on the configuration, even if the data source is capable of providing additional data. The collected data is then processed to detect security vulnerabilities associated with the IAM accounts.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 6, 2017
    Inventors: John Leslie Harter, David Walsh Palmieri, Jeffrey Tobias Robke