Abstract: An in vitro tissue plate may include a well plate, a fluidic plate disposed on a bottom surface of the well plate, and a media manifold disposed on a bottom surface of the fluidic plate. The well plate may have at least two wells, including a tissue well and a waste well. The fluid plate may include a fluid channel extending between and fluidly connecting the tissue well to the waste well. The media manifold may include a one or more media outlets fluidly connected to the fluid channel. A tissue layer may be deposited in the tissue well. The tissue layer may include human cells such as neurovascular cells.

Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

Abstract: A modular system is provided for assembling a structure to secure to opposite sides of a fracture in a bone of a subject. The modular system includes a plate with a perimeter including a plurality of openings. The perimeter defines an interior area within the plate. The modular system also includes a link with one or more openings along a linear axis defining the link. The one or more openings of the link include a connector to receive a fastener to be secured in the bone. The plurality of openings of the plate includes a first opening with an inner diameter configured to removably receive an outer diameter of the connector of the link so that the link is rotatably received within the first opening. A method is also provided for assembling the structure using the modular system and securing the assembled structure to opposite sides of the bone fracture.

Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

Abstract: An identity and access management IAM system is augmented to provide for supervised, iterative machine learning (ML), preferably with a user-generated training set for classification. The training set may include various types of data, including characteristics or attributes of the account types, the users, or the like. A goal of the initial ML training, which may include one or multiple passes, is to enable the machine to identify specific characteristics or attributes that provide a good classification result, with the resulting classifications then applied within the IAM system. In particular, the output of the ML system may be used by the IAM system for enforcing rights associated with the identified accounts, managing accounts, and so forth.

Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.

Abstract: A method of provisioning a plurality of applications from different application developer systems to a network provider system comprises establishing a plurality of service accounts for a corresponding plurality of application service provider systems, receiving a plurality of API interfaces from the plurality of application service provider systems, integrating, by the processor system, each of the plurality of API interfaces with a unified services platform API interface, receiving a provider API interfaces for a network provider system, and integrating the provider API interface with the unified services platform API interface. The plurality of application service provider systems provide services for use in association with a telephone number of a subscriber of telecommunication services. At least two of the API interfaces are different, and at least one of the plurality of API interfaces from the plurality of application service provider systems is not compatible with the provider API interface.

Abstract: An identity and access management (IAM) system is associated with a set of data sources from which data is collected. A set of vulnerabilities that the IAM system should attempt to detect is identified. For each vulnerability to be detected, a prioritized list of strategies used to detect that vulnerability is generated. Preferably, each strategy specifies the type(s) of data required to detect that vulnerability. An algorithm to determine a best strategy to be used for detecting each vulnerability, preferably based on the data available from the data sources, is then identified. The IAM system then collects data in an optimized manner. In particular, during the collection process, the IAM system preferably collects only what is necessary based on the configuration, even if the data source is capable of providing additional data. The collected data is then processed to detect security vulnerabilities associated with the IAM accounts.

Abstract: A heat sink for electronic devices, such as wearable displays, dissipates heat away from and electrical component, such as a microprocessor. An adjustable support assembly permits adjustment of a visual display relative to a user's field of view.

Abstract: An identity and access management (IAM) system is associated with a set of data sources from which data is collected. A set of vulnerabilities that the IAM system should attempt to detect is identified. For each vulnerability to be detected, a prioritized list of strategies used to detect that vulnerability is generated. Preferably, each strategy specifies the type(s) of data required to detect that vulnerability. An algorithm to determine a best strategy to be used for detecting each vulnerability, preferably based on the data available from the data sources, is then identified. The IAM system then collects data in an optimized manner. In particular, during the collection process, the IAM system preferably collects only what is necessary based on the configuration, even if the data source is capable of providing additional data. The collected data is then processed to detect security vulnerabilities associated with the IAM accounts.