Abstract: A buoy, and systems and methods for rescuing people isolated on large bodies of water are disclosed. The buoy includes a remotely activatable device that is activatable when a signal is received from a remote source. The activatable device may be a signaling device, or an assistance device that is deployable by the buoy to assist in rescuing a person. A marine communication system formed by a number of spaced apart rescue buoys is also provided. A message or key other information can be transmitted to every buoy in the network via communication with just one buoy. The methods for rescuing people isolated on large bodies of water involve providing the network of communication buoys that can receive communications from the isolated person's personal communication device, and then transmit a signal to remotely activate an activatable device in a buoy to assist in the rescue of the person.

Abstract: Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: There is disclosed a method of operating an autonomous vehicle (AV), including: detecting an alert condition within the AV via data from an electronic sensor suite of the AV; based at least in part on detecting the alert condition, automatically initiating a call with another party; and communicatively coupling a passenger of the AV to the conference call, whereby the passenger can communicate with the other party via the conference call.

Abstract: A method of providing an onboard assistant for a vehicle, comprising: receiving sensor data from sensors of the vehicle; transforming the sensor data using a trained machine learning model to provide transformed sensor data; inferring from the transformed sensor data that a special condition for the vehicle requires intervention; and contacting an operator of the vehicle to inform the operator of the special condition and receive instructions for handling the special condition.

Abstract: Toilet tissue having a dynamic surface comprising a surface material that overlays a textured web material such that the toilet tissue exhibits one or more novel properties and method for making same are provided.

Abstract: A method of providing an onboard assistant for a vehicle, comprising: receiving sensor data from sensors of the vehicle; transforming the sensor data using a trained machine learning model to provide transformed sensor data; inferring from the transformed sensor data that a special condition for the vehicle requires intervention; and contacting an operator of the vehicle to inform the operator of the special condition and receive instructions for handling the special condition.

Abstract: A system for storing and disseminating knowledge contained in documents includes a document annotator that creates a structured syntactic textual model of each of the documents, an ontology directed extractor that extracts properties from the textual models, a database for storing the textual models and the properties, and an interface permitting queries to the database. The document annotator includes a plurality of data transformers and a plurality of custom annotator tools. The ontology directed extractor includes an ontology based schema definition and a plurality of ontology based data transformers. The user interface includes the ability to view, search, navigate, create, and exchange documents. The creation feature includes a transclusion function.

Abstract: A battery pack comprising a substrate comprising a battery power bus integrated into the substrate; and a pack controller; and at least one electrochemical cell connected directly to the substrate. A printed circuit board comprising a power bus integrated into the printed circuit board, wherein the power bus is connected to and configured to transfer power to and/or from at least one electrochemical cell; and at least one controller configured to control the at least one electrochemical cell. A thermal management system comprising at least one electrochemical cell; and a substrate directly connected to the at least one electrochemical cell and configured to transfer heat, power, and signals between the substrate and the at least one electrochemical cell. A thermal management method. A method of assembling a battery pack, comprising attaching at least one electrochemical cell of the battery pack directly to a substrate at least in part by welding.

Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.

Abstract: A method for evaluating spatially resolved actual sensor data recorded with at least one sensor. The actual sensor data are read first. A location and an orientation of the actual sensor data are ascertained. A spatially resolved map with spatially resolved expectations of sensor data is read. The spatially resolved expectations of the sensor data are compared to the actual sensor data. A property can be ascertained from the comparison. An estimation can take place as to what influence an error source has on the comparison of the spatially resolved expectations of the sensor data to the actual sensor data. It is determined whether or not the property is fulfilled, based on the comparison of the spatially resolved expectations of the sensor data to the actual sensor data and based on the estimation of the influence of the error source. The property and a property probability are output.

Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: Methods, apparatus, systems, and articles of manufacture for user-to-avatar mapping and adjustment are disclosed. An example apparatus includes processor circuitry to at least one of instantiate or execute the machine readable instructions to: determine a dissonance between a first orientation of a user in a real-world environment and a second orientation of an avatar in a virtual environment, the avatar corresponding to the user; determine an avatar adjustment value based on the dissonance; and apply the avatar adjustment value to the avatar model to change the second orientation.

Abstract: Systems, devices, and methods for providing a sheet product dispenser with automated product level tracking functionality are provided herein. Various product level sensors are disclosed herein including a product level sensor configured to emit a signal toward an outer circumference of a sheet product roll on a spindle extending along a longitudinal axis and to receive a reflected signal. The product level sensor is positioned a radial distance away from the spindle and aimed to emit the signal in a direction that is not parallel and not perpendicular to the longitudinal axis. The product level sensor detects a parameter of the reflected signal corresponding to the distance between the product level sensor and the sheet product roll. Other example embodiments include mechanical product level sensors. Various communication protocols may be employed to limit transmission of data to conserve battery life while still maintaining desired communication functionality.

Abstract: A battery pack comprising a substrate comprising a battery power bus integrated into the substrate; and a pack controller; and at least one electrochemical cell connected directly to the substrate. A printed circuit board comprising a power bus integrated into the printed circuit board, wherein the power bus is connected to and configured to transfer power to and/or from at least one electrochemical cell; and at least one controller configured to control the at least one electrochemical cell. A thermal management system comprising at least one electrochemical cell; and a substrate directly connected to the at least one electrochemical cell and configured to transfer heat, power, and signals between the substrate and the at least one electrochemical cell. A thermal management method. A method of assembling a battery pack, comprising attaching at least one electrochemical cell of the battery pack directly to a substrate at least in part by welding.

Abstract: Batteries including electrochemical cells, associated components, and arrangements thereof are generally described. In some aspects, batteries with phase change materials that can facilitate heat transfer within the battery (e.g., from an electrochemical cell to a component of a housing of the battery) are described. In some instances, the phase change material is in thermal communication with a thermally conductive solid article portion (e.g., a cooling fin). In some embodiments, the batteries include a multiplexing switch apparatus. Such a multiplexing switch apparatus may be used to selectively discharge one or more electrochemical cells of the battery.

Abstract: Sanitary tissue products employing fibrous structures that exhibit novel combination of slip stick coefficient of friction and compressibility properties and methods for making same.

Abstract: The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in the methods of the invention.

Abstract: Systems and methods to detect a scratch are provided. The method includes identifying, via an OPTICS technique, a cluster of points on an image. The method also includes utilizing a principal curves technique to identify a curve that approximates one or more points of the cluster of points as a smooth curve. The method further includes determining one or more characteristics of the curve. The method further includes determining one or more characteristics of the cluster. The method further includes identifying a scratch based on at least one of the one or more characteristics of the curve and the one or more characteristics of the cluster.

Abstract: Sanitary tissue products employing fibrous structures that exhibit novel combination of slip stick coefficient of friction and compressibility properties and methods for making same.