Abstract: A method and test system for detecting the presence of an analyte in a sample comprising a binding region and a detecting region, where the binding region contains a plurality of magnetic beads attached to a plurality of first capture molecules that bind to an analyte of interest in the sample, and a plurality of second capture molecules having a detectable label attached thereto, where the second capture molecules bind to the analyte of interest to form a complex, where the complexes are moved through at least one liquefied aliphatic partition via a magnetic field into the detecting region that having a detection composition allows for detection and, optionally, for signal quantification.

Abstract: Preemptive flushing of data involved in executing a processing-in-memory command, from a cache system to main memory that is accessible by a processing-in-memory component, is described. In one example, a system includes an asynchronous flush controller that receives an indication of a subsequent processing-in-memory command to be executed as part of performing a computational task. While earlier commands of the computational task are executed, the asynchronous flush controller evicts or invalidates data elements involved in executing the subsequent processing-in-memory command from the cache system, such that the processing-in-memory command can proceed without stalling.

Abstract: A method includes receiving, at a security platform, a plurality of threat indicators associated with current intrusive activities with respect to computing resources of a first entity and receiving, at the security platform, a plurality of threat datasets associated with prior intrusive activities with respect to computing resources associated with one or more entities including the first entity. The method further includes receiving, at the security platform, a plurality of environmental datasets associated with the computing resources of the first entity and determining an alert level associated with a first threat indicator of the plurality of threat indicators based on the plurality of threat datasets and the plurality of environmental datasets. The method further includes generating, responsive to the alert level satisfying an alert threshold criterion, an alert associated with the first threat indicator for one or more users of the first entity.

Abstract: A method for evaluating spatially resolved actual sensor data acquired using at least one sensor. The method includes: ascertaining a location and an orientation of the sensor at the time of acquiring the sensor data; retrieving a spatially resolved expectation from a spatially resolved map on the basis of the location and the orientation of the sensor; checking to what extent the actual sensor data are consistent with the expectation; at least with respect to the locations for which the actual sensor data are consistent with the expectation, determining that the scene observed by the sensor has a characteristic stored in the map in conjunction with the expectation.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Disclosed are various examples of automated dispensers to dispense consumable products, such as paper towels, gels, liquids, gases, aerosols, foams, and other consumables. Automated dispensers can operate in various modes. Examples of the disclosure can utilize a dispense profile to adjust the speed at which consumable products are dispensed.

Abstract: A blade assembly includes a blade support frame, and a plurality of V-shaped blades removably fastened to the blade support frame. The blade support frame has a food flow path extending downstream, and a plurality of blade mounts distributed around the food flow path. Each V-shaped blade has a first end portion connected to one of the blade mounts, a second end portion connected to another of the blade mounts, and an intermediate portion extending from the first end portion to the second end portion into the food flow path. At the first and second end portions of each V-shaped blade, a respective one of the blade mounts overlies both the upstream edge and the downstream edge of the V-shaped blade to inhibit the V-shaped blade from rotating when impacted by food.

Abstract: A buoy, and systems and methods for rescuing people isolated on large bodies of water are disclosed. The buoy includes a remotely activatable device that is activatable when a signal is received from a remote source. The activatable device may be a signaling device, or an assistance device that is deployable by the buoy to assist in rescuing a person. A marine communication system formed by a number of spaced apart rescue buoys is also provided. A message or key other information can be transmitted to every buoy in the network via communication with just one buoy. The methods for rescuing people isolated on large bodies of water involve providing the network of communication buoys that can receive communications from the isolated person's personal communication device, and then transmit a signal to remotely activate an activatable device in a buoy to assist in the rescue of the person.

Abstract: Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: There is disclosed a method of operating an autonomous vehicle (AV), including: detecting an alert condition within the AV via data from an electronic sensor suite of the AV; based at least in part on detecting the alert condition, automatically initiating a call with another party; and communicatively coupling a passenger of the AV to the conference call, whereby the passenger can communicate with the other party via the conference call.

Abstract: Toilet tissue having a dynamic surface comprising a surface material that overlays a textured web material such that the toilet tissue exhibits one or more novel properties and method for making same are provided.

Abstract: A method of providing an onboard assistant for a vehicle, comprising: receiving sensor data from sensors of the vehicle; transforming the sensor data using a trained machine learning model to provide transformed sensor data; inferring from the transformed sensor data that a special condition for the vehicle requires intervention; and contacting an operator of the vehicle to inform the operator of the special condition and receive instructions for handling the special condition.

Abstract: A method of providing an onboard assistant for a vehicle, comprising: receiving sensor data from sensors of the vehicle; transforming the sensor data using a trained machine learning model to provide transformed sensor data; inferring from the transformed sensor data that a special condition for the vehicle requires intervention; and contacting an operator of the vehicle to inform the operator of the special condition and receive instructions for handling the special condition.

Abstract: A system for storing and disseminating knowledge contained in documents includes a document annotator that creates a structured syntactic textual model of each of the documents, an ontology directed extractor that extracts properties from the textual models, a database for storing the textual models and the properties, and an interface permitting queries to the database. The document annotator includes a plurality of data transformers and a plurality of custom annotator tools. The ontology directed extractor includes an ontology based schema definition and a plurality of ontology based data transformers. The user interface includes the ability to view, search, navigate, create, and exchange documents. The creation feature includes a transclusion function.

Abstract: A battery pack comprising a substrate comprising a battery power bus integrated into the substrate; and a pack controller; and at least one electrochemical cell connected directly to the substrate. A printed circuit board comprising a power bus integrated into the printed circuit board, wherein the power bus is connected to and configured to transfer power to and/or from at least one electrochemical cell; and at least one controller configured to control the at least one electrochemical cell. A thermal management system comprising at least one electrochemical cell; and a substrate directly connected to the at least one electrochemical cell and configured to transfer heat, power, and signals between the substrate and the at least one electrochemical cell. A thermal management method. A method of assembling a battery pack, comprising attaching at least one electrochemical cell of the battery pack directly to a substrate at least in part by welding.

Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.

Abstract: A method for evaluating spatially resolved actual sensor data recorded with at least one sensor. The actual sensor data are read first. A location and an orientation of the actual sensor data are ascertained. A spatially resolved map with spatially resolved expectations of sensor data is read. The spatially resolved expectations of the sensor data are compared to the actual sensor data. A property can be ascertained from the comparison. An estimation can take place as to what influence an error source has on the comparison of the spatially resolved expectations of the sensor data to the actual sensor data. It is determined whether or not the property is fulfilled, based on the comparison of the spatially resolved expectations of the sensor data to the actual sensor data and based on the estimation of the influence of the error source. The property and a property probability are output.

Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: Methods, apparatus, systems, and articles of manufacture for user-to-avatar mapping and adjustment are disclosed. An example apparatus includes processor circuitry to at least one of instantiate or execute the machine readable instructions to: determine a dissonance between a first orientation of a user in a real-world environment and a second orientation of an avatar in a virtual environment, the avatar corresponding to the user; determine an avatar adjustment value based on the dissonance; and apply the avatar adjustment value to the avatar model to change the second orientation.