Abstract: The present invention relates to a system and method for, for example, periodically collecting physiological parameters in real-time from a plurality of subjects, for example temperature from cancer patients, heartbeat rates from persons being treated for coronary conditions, physiological orientation information mechanical shock and related parameters, for example from football players in danger of head trauma, and other physiological measurements which it real-time convey useful information. This information is coupled to a system which integrates the information, subjects it to criteria (for example doctor-specified dangerous condition criteria), communicates information and, optionally provides alarms to clinicians.

Abstract: A battery pack comprising a substrate comprising a battery power bus integrated into the substrate; and a pack controller; and at least one electrochemical cell connected directly to the substrate. A printed circuit board comprising a power bus integrated into the printed circuit board, wherein the power bus is connected to and configured to transfer power to and/or from at least one electrochemical cell; and at least one controller configured to control the at least one electrochemical cell. A thermal management system comprising at least one electrochemical cell; and a substrate directly connected to the at least one electrochemical cell and configured to transfer heat, power, and signals between the substrate and the at least one electrochemical cell. A thermal management method. A method of assembling a battery pack, comprising attaching at least one electrochemical cell of the battery pack directly to a substrate at least in part by welding.

Abstract: An infusion pump may include automated syringe loading capabilities and/or medicinal fluid delivery capabilities to facilitate administration of medicinal fluids to a patient. The infusion pump may operate mechanically and may not require a power source to operate. The infusion pump may assist with filling a syringe with the medicinal fluid contents of one or more vials. The infusion pump may include a drug delivery assembly to deliver fluid at an adjustable but constant force. The infusion pump may permit the user to adjust the delivery rate continuously within a given range to improve comfort during infusion.

Abstract: The present invention relates to a system and method for, for example, periodically collecting physiological parameters in real-time from a plurality of subjects, for example temperature from cancer patients, heartbeat rates from persons being treated for coronary conditions, physiological orientation information mechanical shock and related parameters, for example from football players in danger of head trauma, and other physiological measurements which it real-time convey useful information. This information is coupled to a system which integrates the information, subjects it to criteria (for example doctor-specified dangerous condition criteria), communicates information and, optionally provides alarms to clinicians.

Abstract: The present invention relates to a system and method for, for example, periodically collecting physiological parameters in real-time from a plurality of subjects, for example temperature from cancer patients, heartbeat rates from persons being treated for coronary conditions, physiological orientation information mechanical shock and related parameters, for example from football players in danger of head trauma, and other physiological measurements which it real-time convey useful information. This information is coupled to a system which integrates the information, subjects it to criteria (for example doctor-specified dangerous condition criteria), communicates information and, optionally provides alarms to clinicians. The inventive transducer comprises a flexible frame which easily conforms to the body. Optionally, an adhesive for sealing to the skin ensures good skin contact and moisture protection for the electronics and the device.

Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.

Abstract: Updates are managed across partitions in a distributed cloud allocation system. Updates are managed in a variety of dimensions, e.g., by partition, time, or upgrade domain, to maintain a sufficient number of allocator instances to maintain service. An update service may receive, organize, schedule, and deliver updates to VM allocator instances to limit service disruptions. Updates may be aggregated based on partition scope. Updates to one or more partitions may be batched in a single update. Delivery and timing of updates may be configurable on a per partition basis. Allocator instances may receive batched updates at the same or different times. An update service may dynamically adapt to prevailing service conditions if an essential update is in progress and/or request demand is above a threshold.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: A blade assembly includes a blade support frame, and a plurality of V-shaped blades removably fastened to the blade support frame. The blade support frame has a food flow path extending downstream, and a plurality of blade mounts distributed around the food flow path. Each V-shaped blade has a first end portion connected to one of the blade mounts, a second end portion connected to another of the blade mounts, and an intermediate portion extending from the first end portion to the second end portion into the food flow path. At the first and second end portions of each V-shaped blade, a respective one of the blade mounts overlies both the upstream edge and the downstream edge of the V-shaped blade to inhibit the V-shaped blade from rotating when impacted by food.

Abstract: A catalytic wall-flow filter for exhaust gas from a gasoline engine is disclosed. The catalytic wall-flow filter comprises a wall-flow filter substrate, a first TWC coating in the first plurality of channels, and a second TWC coating in the second plurality of channels. The first TWC coating comprises palladium, rhodium, a first oxygen storage capacity (OSC) material, and a first inorganic support. The second TWC coating comprises platinum, rhodium, a second OSC material, and a second inorganic support.

Abstract: The present invention relates to a system and method for, for example, periodically collecting physiological parameters in real-time from a plurality of subjects, for example temperature from cancer patients, heartbeat rates from persons being treated for coronary conditions, physiological orientation information mechanical shock and related parameters, for example from football players in danger of head trauma, and other physiological measurements which it real-time convey useful information. This information is coupled to a system which integrates the information, subjects it to criteria (for example doctor-specified dangerous condition criteria), communicates information and, optionally provides alarms to clinicians. The invention allows for real-time monitoring of skull impacts, for example to players in a sports game, allowing the reliable identification of dangerous impacts at a quick determination whether I had cooling device should be promptly applied to minimize long-term injury.

Abstract: A shower head including first and second coupling elements. One of the coupling elements is a male coupling element and the other coupling element is a female coupling element. The male coupling element is inserted into the female coupling element, and when attached, the male coupling element is overlapped by the female coupling element.

Abstract: A method for evaluating spatially resolved actual sensor data recorded with at least one sensor. The actual sensor data are read first. A location and an orientation of the actual sensor data are ascertained. A spatially resolved map with spatially resolved expectations of sensor data is read. The spatially resolved expectations of the sensor data are compared to the actual sensor data. A property can be ascertained from the comparison. An estimation can take place as to what influence an error source has on the comparison of the spatially resolved expectations of the sensor data to the actual sensor data. It is determined whether or not the property is fulfilled, based on the comparison of the spatially resolved expectations of the sensor data to the actual sensor data and based on the estimation of the influence of the error source. The property and a property probability are output.

Abstract: Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: There is disclosed a method of providing rider service for an autonomous vehicle (AV) system, including operating an AV to provide a trip to a passenger; associating the passenger with a unique passenger identifier (UPID); receiving passenger metadata for the passenger according to the UPID; and responding to a rider service instance, comprising customizing the response according to the UPID and the passenger metadata.

Abstract: Methods, apparatus, systems, and articles of manufacture for user-to-avatar mapping and adjustment are disclosed. An example apparatus includes processor circuitry to at least one of instantiate or execute the machine readable instructions to: determine a dissonance between a first orientation of a user in a real-world environment and a second orientation of an avatar in a virtual environment, the avatar corresponding to the user; determine an avatar adjustment value based on the dissonance; and apply the avatar adjustment value to the avatar model to change the second orientation.

Abstract: Systems, devices, and methods for providing a sheet product dispenser with automated product level tracking functionality are provided herein. Various product level sensors are disclosed herein including a product level sensor configured to emit a signal toward an outer circumference of a sheet product roll on a spindle extending along a longitudinal axis and to receive a reflected signal. The product level sensor is positioned a radial distance away from the spindle and aimed to emit the signal in a direction that is not parallel and not perpendicular to the longitudinal axis. The product level sensor detects a parameter of the reflected signal corresponding to the distance between the product level sensor and the sheet product roll. Other example embodiments include mechanical product level sensors. Various communication protocols may be employed to limit transmission of data to conserve battery life while still maintaining desired communication functionality.

Abstract: A blending container may comprise a body forming a cavity. The body may comprise a closed end having a blade assembly, wherein the closed end is configured to operatively couple to a motor base. The blending container may also comprise an open end opposite the closed end, that comprises a perimeter edge defining an opening, wherein at least a portion of the perimeter edge is configured to operatively receive a serving lid or serving cup when the closed end is operatively coupled to the motor base.

Abstract: An optical system is provided that includes a conduit fitting, a first connector, a first conduit, a first ferrule and a first nut. The conduit fitting includes a receptacle. The first connector is disposed within the receptacle. The first connector includes a first bore, a first counterbore and a first port radially outboard of the first bore. The first conduit includes a first optics line and a first fluid passage. The first conduit projects longitudinally into the first counterbore and is attached to the first connector. The first optics line projects longitudinally into the first bore. The first fluid passage is fluidly coupled with the first port. The first ferrule circumscribes the first connector. The first nut is threaded onto the conduit fitting and is configured to wedge the first ferrule radially between the first connector and the conduit fitting.