Abstract: A controller for a power converter includes a driver circuit that generates a control signal to switch a power switch in response to an output, and a control circuit that controls the switching of the power switch. The control circuit includes a storage time reference circuit generates a storage time reference signal responsive to an input. A first comparator generates a collector off signal in response to a comparison of a switch current sense signal and a collector off reference signal. A storage time regulator circuit generates a base off reference signal in response to the storage time reference signal and the collector off signal. A second comparator generates a base off signal in response to a second comparison of the switch current sense signal and the base off reference signal. The driver circuit is coupled to discontinue and start charging a base terminal of the BJT power switch.

Abstract: A switched mode power converter has an energy transfer element that delivers an output signal to a load. A power switching device coupled to the primary side of the energy transfer element regulates a transfer of energy to the load. A secondary controller is coupled to receive a feedback signal and output a pulsed signal in response thereto. A primary controller is coupled to receive the pulsed signal and output a drive signal in response thereto, the drive signal being coupled to control switching of the power switching device. A compensation circuit generates an adaptively compensated signal synchronous with the pulsed signal. The adaptively compensated signal has a parameter that is adaptively adjusted in response to a comparison of the feedback signal with a threshold reference signal. The parameter converges towards a final value that produces a desired level of the output signal.

Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract: A controller for use in a two-stage power supply is coupled to control switching of a switching element to regulate a transfer of energy from an input to an output of a flyback converter. The controller activates a boost switching element during a first interval in each line half cycle of an input voltage to boost an output voltage at an output of a boost-bypass converter. The controller deactivates the boost switching element during a second interval in each line half cycle such that the output voltage of the boost-bypass converter drops towards the input voltage during the second interval while the output voltage of the boost-bypass converter is greater than the input voltage. The controller controls the output voltage to follow the input voltage during a third interval of each line half cycle while the boost switching element remains deactivated and the input and output voltages are substantially equal.

Abstract: A power converter includes a primary winding and multiple output windings to provide multiple independently controlled and regulated outputs with a common return line. The outputs are coupled to independently regulate constant current, constant voltage, or both constant current and constant voltage outputs. A secondary control block is coupled to control a synchronous rectifier switch coupled to the common return line to synchronize switching with a primary side power switch to provide complementary conduction of the primary winding and the multiple output windings. A plurality of controlled power pulse switches is coupled to the multiple output windings. A request of a power pulse from each of the outputs is transferred through the secondary control block to a primary switch control block to turn on the primary side power switch to transfer a power pulse to the multiple output windings and through controlled power pulse switches to the outputs.

Abstract: A controller for use in a two-stage power supply is coupled to control switching of a switching element to regulate a transfer of energy from an input to an output of a flyback converter. The controller activates a boost switching element during a first interval in each line half cycle of an input voltage to boost an output voltage at an output of a boost-bypass converter. The controller deactivates the boost switching element during a second interval in each line half cycle such that the output voltage of the boost-bypass converter drops towards the input voltage during the second interval while the output voltage of the boost-bypass converter is greater than the input voltage. The controller controls the output voltage to follow the input voltage during a third interval of each line half cycle while the boost switching element remains deactivated and the input and output voltages are substantially equal.

Abstract: The present invention is related to a use of triazolopyrimidine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to triazolopyrimidine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract: A boost-bypass converter includes a boost inductor coupled between an input and an output of the boost-bypass converter. A bypass diode is coupled between the input the output of the boost-bypass converter. A boost switching element is coupled to the boost inductor, and is coupled to be activated during a first interval in each line half cycle of an input voltage to boost an output voltage at the output of the boost-bypass converter. The boost switching element is coupled to be deactivated during a second interval in said each line half cycle such that the output voltage drops towards the input voltage. The output voltage is coupled to follow the input voltage during a third interval in said each line half cycle of the input voltage. Energy is transferred between the input and the output of the boost-bypass converter through the bypass diode during the third interval.

Abstract: A controller for use in a power converter includes a first edge detection circuit that receives a first input sense signal representative of an input of the power converter coupled to a dimmer circuit, and generates a first edge detection signal in response to the first input sense signal. A shaping circuit receives the first edge detection signal from the first edge detection circuit. The shaping circuit generates a first shape signal in response to the first edge detection signal. A drive circuit receives the first shape signal and a feedback signal representative of an output of the power converter. The drive circuit generates the drive signal in response to the feedback signal to control switching of a power switch of the power converter. The drive circuit switches the power switch in a first higher current mode for a first duration in response to the first shape signal.

Abstract: A boost-bypass converter includes a boost inductor coupled between an input and an output of the boost-bypass converter. A bypass diode is coupled between the input the output of the boost-bypass converter. A boost switching element is coupled to the boost inductor, and is coupled to be activated during a first interval in each line half cycle of an input voltage to boost an output voltage at the output of the boost-bypass converter. The boost switching element is coupled to be deactivated during a second interval in said each line half cycle such that the output voltage drops towards the input voltage. The output voltage is coupled to follow the input voltage during a third interval in said each line half cycle of the input voltage. Energy is transferred between the input and the output of the boost-bypass converter through the bypass diode during the third interval.

Abstract: A controller for a power converter includes a driver circuit that generates a control signal to switch a power switch in response to an output, and a control circuit that controls the switching of the power switch. The control circuit includes a storage time reference circuit generates a storage time reference signal responsive to an input. A first comparator generates a collector off signal in response to a comparison of a switch current sense signal and a collector off reference signal. A storage time regulator circuit generates a base off reference signal in response to the storage time reference signal and the collector off signal. A second comparator generates a base off signal in response to a second comparison of the switch current sense signal and the base off reference signal. The driver circuit is coupled to discontinue and start charging a base terminal of the BJT power switch.

Abstract: A power converter controller includes a storage time reference circuit to generate a storage time reference signal in response to an input voltage signal. A first comparator generates a collector off signal in response to a current sense signal of a BJT and a collector off reference threshold signal. A storage time regulator circuit generates a base off reference threshold signal in response to the storage time reference signal and the collector off signal. A second comparator generates a base off signal in response to the current sense signal and a base off reference threshold signal. A driver circuit controls switching of the BJT in response to an output voltage signal, discontinues charging a base terminal of the BJT in response to the base off signal, and starts discharging the base terminal of the BJT in response to the collector off signal during a switching cycle of the BJT.

Abstract: A power converter controller includes a storage time reference circuit to generate a storage time reference signal in response to an input voltage signal. A first comparator generates a collector off signal in response to a current sense signal of a BJT and a collector off reference threshold signal. A storage time regulator circuit generates a base off reference threshold signal in response to the storage time reference signal and the collector off signal. A second comparator generates a base off signal in response to the current sense signal and a base off reference threshold signal. A driver circuit controls switching of the BJT in response to an output voltage signal, discontinues charging a base terminal of the BJT in response to the base off signal, and starts discharging the base terminal of the BJT in response to the collector off signal during a switching cycle of the BJT.

Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract: Compounds of formula (I) Q-L-W—C(?X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.

Abstract: Compounds of formula (I) Q-L-W—C(?X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.

Abstract: The present invention relates to compounds of formula (I) The compounds act via antagonism of the CCR2b receptor and may be used to treat inflammatory disease and/or neuropathic pain.