Abstract: The disclosures herein relate to novel compounds of Formula (1a): and salts thereof, wherein W, Z, L, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with CGRP receptors.

Abstract: The invention is a system and method of minimally invasive treatment with wire structure electrodes dispensed without open cut downs or laparoscopy and using energy forms including radiofrequency, microwave, direct current, and high intensity focused ultrasound.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: A method of processing a counting output associated with a counting device comprising: (i) calculating a first time-to-count average value based on time-to-count values obtained for a number of events ‘n’ between events x1 and xn; (ii) measuring a time-to-count value associated with event xn+1; and (iii) calculating a second time-to-count average value based on time-to-count values obtained for the number of events ‘n’ between events x2 and xn+1.

Abstract: A lighting device for foreign object debris (FOD) detection is included. The lighting device includes a light source configured to emit light onto a surface, and a diffuser coupled to the light source and configured to cause the emitted light to impinge the surface in at least a partially planar pattern, so as to create a darkfield lighting effect with respect to the surface. The lighting device further includes a cylindrical rod including a first end portion and a second end portion, in which the first end portion is configured to couple to the light source and the diffuser and the second end portion is configured to be manually held by a user of the portable lighting device.

Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: A method of measuring a position of a scanning cantilever includes providing a housing including an actuation region, a position measurement region including an aperture, and an oscillation region. The method also includes providing a drive signal to an actuator disposed in the actuation region, oscillating the scanning cantilever in response to the drive signal, generating a first light beam using a first optical source, directing the first light beam toward the aperture, detecting at least a portion of the first light beam using a first photodetector, generating a second light beam using a second optical source, directing the second light beam toward the aperture, detecting at least a portion of the second light beam using a second photodetector, and determining the position of the scanning cantilever based on the detected portion of the first light beam and the detected portion of the second light beam.

Abstract: The invention relates to an internal combustion engine (10) comprising a cylinder block (12) comprising a plurality of cylinders. The engine (10) comprises a crankshaft (14) rotatably mounted on the cylinder block (12) about a crankshaft rotation axis (16) extending in a plane (18) which, with respect to an installation position of the internal combustion engine (10), extends in a vertical direction (20) of the vehicle. The engine (10) comprises a mounting bracket (26) separately manufactured from the cylinder block (12), the mounting bracket (26) being attached to the cylinder block (12). The engine (10) comprises a belt (30) configured to be driven by the crankshaft (14). The engine (10) comprises an alternator (34) configured to be driven by the belt (30), the alternator (34) being mounted on the mounting bracket (26). The engine (10) comprises a hydraulic steering pump (38) configured to be driven by the belt (30).

Abstract: The disclosures herein relate to novel compounds of Formula (1a): and salts thereof, wherein W, Z, L, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with CGRP receptors.

Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.

Abstract: There is described a device for adjusting a seat position of a bicycle seat. The device allows a rider of a bicycle to adjust the tilt of their bicycle seat while the bicycle is in motion, without the rider having to first dismount. In some embodiments, the rider may also adjust the height of their bicycle seat at substantially the same time as the seat's tilt is adjusted, again without the rider having to first dismount. There are described a motorized embodiment in which one or more motors are used to drive a tilt actuator and a linear actuator, and a mechanized embodiment in which a source of pressurized air may be used to drive the linear actuator which in turn drives the tilt actuator.

Abstract: The embodiments disclose an optical density measurement and testing system including a purification device configured to detect and isolate live cancer cells of a patient microbiology sample, a drug addition device configured to infuse a drug treatment to the live cancer cells, an optical density device configured to capture images of the microbiology sample, an optical microplate spectrophotometric reader coupled to the optical density device configured to measure the density of living cells after infusion of the at least one drug treatment, a computer coupled to the optical microplate spectrophotometric reader configured to determine measured rates of death over a period of time based on the interval population growth data, and an optical density application operating on the computer configured to use the measured rates of death and known predetermined genetic markers, resistances and allergies of the patient associated with the drug to generate clinician treatment recommendations for the patient.

Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.

Abstract: The present invention relates to antibodies that are specific for SARS-CoV-2. The present invention also provides methods of treatment, uses, pharmaceutical compositions and kits comprising the antibodies.

Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.

Abstract: There is described a device for adjusting a seat position of a bicycle seat. The device allows a rider of a bicycle to adjust the tilt of their bicycle seat while the bicycle is in motion, without the rider having to first dismount. In some embodiments, the rider may also adjust the height of their bicycle seat at substantially the same time as the seat's tilt is an adjusted, again without the rider having to first dismount. There are described a motorized embodiment in which one or more motors are used to drive a tilt actuator and a linear actuator, and a mechanized embodiment in which a source of pressurized air may be used to drive the linear actuator which in turn drives the tilt actuator.

Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.

Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.