Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse/addiction and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Abstract: The system can include an inlet valve, a backflow preventer, and a demand pump. The system can further include a first pressure sensor coupled to a computing device and configured to measure pressure between the backflow preventer and the inlet valve. The system can further include a second pressure sensor coupled to a computing device and configured to measure pressure between the backflow preventer and at least one dispensing valve. The computing device can detect that a fluid dispensing event has completed based on a pressure measurement from the second pressure sensor. After a predefined duration from the end of the fluid dispensing event, the computing device can determine measurements at the first pressure sensor and the second pressure sensor. The computing device can determine a leak in a fluid pathway based on a change in a pressure measurement from the first pressure sensor or the second pressure sensor.

Abstract: Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.

Abstract: The system can include an inlet valve, a backflow preventer, and a demand pump. The system can further include a first pressure sensor coupled to a computing device and configured to measure pressure between the backflow preventer and the inlet valve. The system can further include a second pressure sensor coupled to a computing device and configured to measure pressure between the backflow preventer and at least one dispensing valve. The computing device can detect that a fluid dispensing event has completed based on a pressure measurement from the second pressure sensor. After a predefined duration from the end of the fluid dispensing event, the computing device can determine measurements at the first pressure sensor and the second pressure sensor. The computing device can determine a leak in a fluid pathway based on a change in a pressure measurement from the first pressure sensor or the second pressure sensor.

Abstract: A nozzle for beverage dispensing. The nozzle accepts both hot water lines and cold water lines at the nozzle, where the water may be carbonated or still. Cold carbonated water is received near the top of a double cone-shaped insert within the nozzle interior. The cold carbonated water is depressurized prior to being fully exposed to atmospheric pressure by passing the cold carbonated water down and around the double cone-shape of the insert. The depressurized cold carbonated water is collected via a funnel, and is dispensed from the nozzle after exiting the funnel bottom. Hot water is received in chamber within the nozzle separate from the passageway through which the cold carbonated water flows. Both hot and cold water streams are directed to flow in a tight and narrow downward direction via flow straighteners, and the streams are mixed with flavoring after dispensing from the nozzle.

Abstract: Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.

Abstract: An evaporator can include a pressure vessel and an evaporation device. The evaporation device can be at least partially enclosed within the pressure vessel and configured to direct a refrigerant through the pressure vessel. The evaporator can include at least one fluid direction device at least partially enclosed within the pressure vessel. The at least one fluid direction device is configured to direct a drinking fluid around the evaporation device to facilitate heat exchange. The evaporation device can include an evaporation coil with a first portion, a second portion, and a third portion. The second portion can be located exterior to the first portion and the third portion can be located radially exterior to the second portion. The pressure vessel can include an inlet and outlet in fluid connection with the evaporation coil.

Abstract: A nozzle for beverage dispensing. The nozzle accepts both hot water lines and cold water lines at the nozzle, where the water may be carbonated or still. Cold carbonated water is received near the top of a double cone-shaped insert within the nozzle interior. The cold carbonated water is depressurized prior to being fully exposed to atmospheric pressure by passing the cold carbonated water down and around the double cone-shape of the insert. The depressurized cold carbonated water is collected via a funnel, and is dispensed from the nozzle after exiting the funnel bottom. Hot water is received in chamber within the nozzle separate from the passageway through which the cold carbonated water flows. Both hot and cold water streams are directed to flow in a tight and narrow downward direction via flow straighteners, and the streams are mixed with flavoring after dispensing from the nozzle.

Abstract: Systems, methods, and devices for monitoring and calibrating pump speeds in a beverage dispensing system. A first signal associated with an electrical current supplied to a motor driving a pump may be received and a speed of the pump may be determined. A second signal may be determined based on the first signal and the speed of the pump. Electrical current may be supplied to the motor driving the pump based on the second signal. Additional feedback mechanisms and calibration processes may further reduce dispensing error associated with the pump, enhancing accuracy and reliability of the beverage dispensing system for consistent beverage preparation.

Abstract: The presently-disclosed subject matter relates to diaminobutoxy-substituted isoflavonoids and their use thereof as mitochondrial complex I inhibitors for the treatment of cancer.

Abstract: An inline carbonator can include a body having inlets configured to receive water and carbon dioxide. An inline mixer can be disposed within the body and can comprise a central channel defining an inner flow path extending along the inline mixer in a first direction and a mixing unit defining an outer flow path extending along the inline mixer in a second direction that is generally opposite the first direction. The mixing unit can include a funnel structure defining a funnel flow path and a mixing wall structure having a barrier portion rotationally aligned with the funnel flow path. The inline mixer can include a plurality of mixing units that are serially arranged.

Abstract: Systems and methods for clock synchronization are disclosed. A client synchronization system (CSS) may transmit RF pulses to a server CSS over micrometeorite ionization trail (MMIT) channels, and may receive RF pulses from the server CSS over MMIT channels, each received RF pulse following transmitted RF pulse. The client CSS may receive from the server CSS over MMIT channels measurement data including pulse arrival times at the server CSS. The measurement and transmission data may be correlated to identify RF-pulse pairs, each pairing a transmitted RF pulse received by the server CSS with a received RF pulse received from the server CSS, both over the same MMIT. TWTT analysis may be applied to timing data the pairs to compute time offsets between a client clock and a server clock. An analytical model of clock drift may be applied to the offsets to synchronize the client clock to the server clock.

Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Abstract: A nozzle for beverage dispensing. The nozzle accepts both hot water lines and cold water lines at the nozzle, where the water may be carbonated or still. Cold carbonated water is received near the top of a double cone-shaped insert within the nozzle interior. The cold carbonated water is depressurized prior to being fully exposed to atmospheric pressure by passing the cold carbonated water down and around the double cone-shape of the insert. The depressurized cold carbonated water is collected via a funnel, and is dispensed from the nozzle after exiting the funnel bottom. Hot water is received in chamber within the nozzle separate from the passageway through which the cold carbonated water flows. Both hot and cold water streams are directed to flow in a tight and narrow downward direction via flow straighteners, and the streams are mixed with flavoring after dispensing from the nozzle.

Abstract: Systems and methods for clock synchronization are disclosed. A client synchronization system (CSS) may transmit RF pulses to a server CSS over micrometeorite ionization trail (MMIT) channels, and may receive RF pulses from the server CSS over MMIT channels, each received RF pulse following transmitted RF pulse. The client CSS may receive from the server CSS over MMIT channels measurement data including pulse arrival times at the server CSS. The measurement and transmission data may be correlated to identify RF-pulse pairs, each pairing a transmitted RF pulse received by the server CSS with a received RF pulse received from the server CSS, both over the same MMIT. TWTT analysis may be applied to timing data the pairs to compute time offsets between a client clock and a server clock. An analytical model of clock drift may be applied to the offsets to synchronize the client clock to the server clock.

Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse/addiction and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Abstract: Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.

Abstract: Implementation of radio frequency applications in satellite environments can be constrained by size, mass, cost, and power limitations. These applications can include radar, communications, radio astronomy, or other scientific or industrial applications. A variety of systems are provided to facilitate recording of baseband radio frequency signals at high bandwidth and low power using low-cost components. These systems include field-programmable gate arrays or other programmable logic devices integrating between high-frequency ADCs and two or more multiplexed non-volatile storage mediums. Also provided are systems for providing calibration and self-test functionality in a low-cost, flexible, low-power radio frequency frontend. These systems include high-frequency switches configured to allow a calibration and/or self-test pulse to be acquired for each radar pulse generated by the system.

Abstract: A method of inhibiting activity or expression of one or more 3?-oxidoreductase enzymes that share a common catalytic site and convert androstanediol to DHT. The method comprises introducing one or more agents into cells that comprise the one or more 3?-oxidoreductase enzymes, wherein said one or more agents: i) inhibit function of one or more of said enzymes; ii) inhibit translation of mRNA encoding said enzymes; iii) disrupt or delete genes encoding said enzymes; or a combination thereof.

Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.