Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to identify user presence to a meter. An example apparatus includes memory, instructions, and at least one hardware processor to execute the instructions to at least: obtain presence information from a configuration device, the configuration device separate from the apparatus, the presence information indicating that user is present at the apparatus; verify the presence information matches user information, the user information stored in a memory of the apparatus; cause a confirmation prompt to be displayed on the configuration device, the confirmation prompt to indicate the presence information was obtained by the apparatus; and store the presence information in memory.

Abstract: The presently-disclosed subject matter relates to diaminobutoxy-substituted isoflavonoids and their use thereof as mitochondrial complex I inhibitors for the treatment of cancer.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to identify user presence to a meter. An example apparatus includes memory, instructions, and at least one hardware processor to execute the instructions to at least: obtain presence information from a configuration device, the configuration device separate from the apparatus, the presence information indicating that user is present at the apparatus; verify the presence information matches user information, the user information stored in a memory of the apparatus; cause a confirmation prompt to be displayed on the configuration device, the confirmation prompt to indicate the presence information was obtained by the apparatus; and store the presence information in memory.

Abstract: An inline carbonator can include a body having inlets configured to receive water and carbon dioxide. An inline mixer can be disposed within the body and can comprise a central channel defining an inner flow path extending along the inline mixer in a first direction and a mixing unit defining an outer flow path extending along the inline mixer in a second direction that is generally opposite the first direction. The mixing unit can include a funnel structure defining a funnel flow path and a mixing wall structure having a barrier portion rotationally aligned with the funnel flow path. The inline mixer can include a plurality of mixing units that are serially arranged.

Abstract: The present disclosure provides enzymatic methods for the production of 3?-phosphate-nucleoside-5?-triphosphate (NQP). The present disclosure further provides enzymatic methods for the production of nucleotide-5?-triphosphates.

Abstract: The present invention provides engineered 3?O-kinase polypeptides useful for construction of materials used in template-independent polynucleotide synthesis, as well as compositions and methods of utilizing these engineered polypeptides. The present disclosure also describes one-pot methods for conversion of a natural or modified nucleoside to a nucleoside tetraphosphate or NQP.

Abstract: Systems and methods for clock synchronization are disclosed. A client synchronization system (CSS) may transmit RF pulses to a server CSS over micrometeorite ionization trail (MMIT) channels, and may receive RF pulses from the server CSS over MMIT channels, each received RF pulse following transmitted RF pulse. The client CSS may receive from the server CSS over MMIT channels measurement data including pulse arrival times at the server CSS. The measurement and transmission data may be correlated to identify RF-pulse pairs, each pairing a transmitted RF pulse received by the server CSS with a received RF pulse received from the server CSS, both over the same MMIT. TWTT analysis may be applied to timing data the pairs to compute time offsets between a client clock and a server clock. An analytical model of clock drift may be applied to the offsets to synchronize the client clock to the server clock.

Abstract: The present invention provides engineered terminal deoxynucleotidyl transferase (TdT) polypeptides useful in template-independent polynucleotide synthesis, as well as compositions, methods of utilizing these engineered polypeptides, and polynucleotides encoding the engineered terminal deoxynucleotidyl transferases.

Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to identify user presence to a meter. An example apparatus includes memory, instructions, and at least one hardware processor to execute the instructions to at least: obtain presence information from a configuration device, the configuration device separate from the apparatus, the presence information indicating that user is present at the apparatus; verify the presence information matches user information, the user information stored in a memory of the apparatus; cause a confirmation prompt to be displayed on the configuration device, the confirmation prompt to indicate the presence information was obtained by the apparatus; and store the presence information in memory.

Abstract: A Y-shaped refractory anchor, a plurality of Y-shaped refractory anchors, and a method of installing a plurality of Y-shaped refractory anchors in a hexagonal pattern is disclosed. The Y-shaped refractory anchor comprises a singular rectangular folded metal plate comprising a stem that comprises at least one tapered triangular section to be welded to a backing surface and a folded stem base and a branch section comprising two branches, wherein the singular metal plate is folded together at the stem base, such that the stem of the Y-shaped anchor is twice as thick as the two individual branches.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to identify user presence to a meter. An example apparatus includes memory, instructions, and at least one hardware processor to execute the instructions to at least: obtain presence information from a configuration device, the configuration device separate from the apparatus, the presence information indicating that user is present at the apparatus; verify the presence information matches user information, the user information stored in a memory of the apparatus; cause a confirmation prompt to be displayed on the configuration device, the confirmation prompt to indicate the presence information was obtained by the apparatus; and store the presence information in memory.

Abstract: A device is configured to receive a resource request that identifies a first user, a first resource that is currently assigned to the first user, and a second resource that the first user is requesting. The device is further configured to obtain information for the first resource and to determine whether the first user qualifies for the second resource based on the information associated with the first resource and resource allocation requirements for the second resource. The device is further configured to obtain the first resource from the first user and to associate the second resource with the first user for a predetermined period of time. The device is further configured to determine the first user has returned the second resource within the predetermined period of time, to remove the association between the second resource and the first user, and to release the first resource to the first user.

Abstract: The present invention provides novel biocatalysts and associated methods of use for the oxidative desymmetrization of fused bicyclic proline analogues to produce APIs and intermediates. The novel biocatalysts of the present disclosure are engineered monoamine oxidase enzymes with improved solubility, thermostability, and activity on fused bicyclic proline compounds, as compared to a reference monoamine oxidase. In particular, the engineered monoamine oxidase enzymes of the present disclosure require reduced enzyme loading for the manufacturing of APIs and intermediates, as compared to a reference monoamine oxidase enzyme.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to identify user presence to a meter. An example apparatus includes memory, instructions, and at least one hardware processor to execute the instructions to at least: obtain presence information from a configuration device, the configuration device separate from the apparatus, the presence information indicating that user is present at the apparatus; verify the presence information matches user information, the user information stored in a memory of the apparatus; cause a confirmation prompt to be displayed on the configuration device, the confirmation prompt to indicate the presence information was obtained by the apparatus; and store the presence information in memory.

Abstract: Embodiments of the disclosure relate to methods, apparatus and systems for authentication of a user. The described embodiments relate to obtaining ear biometric data for a user to be authenticated. The ear biometric data comprises one or more features characteristic of the user's ear canal and an associated fit metric indicative of a positioning of a personal audio device relative to the user's ear canal, the personal audio device comprising a transducer for application of acoustic stimulus to the user's ear to obtain the ear biometric data. The user may be identified as a particular authorised user based on one or more features and the associated fit metric.

Abstract: A nozzle for beverage dispensing. The nozzle accepts both hot water lines and cold water lines at the nozzle, where the water may be carbonated or still. Cold carbonated water is received near the top of a double cone-shaped insert within the nozzle interior. The cold carbonated water is depressurized prior to being fully exposed to atmospheric pressure by passing the cold carbonated water down and around the double cone-shape of the insert. The depressurized cold carbonated water is collected via a funnel, and is dispensed from the nozzle after exiting the funnel bottom. Hot water is received in chamber within the nozzle separate from the passageway through which the cold carbonated water flows. Both hot and cold water streams are directed to flow in a tight and narrow downward direction via flow straighteners, and the streams are mixed with flavoring after dispensing from the nozzle.

Abstract: A method, comprising: obtaining one or more accelerometer signals derived from an accelerometer; and determining one or more parameters of wind at the accelerometer based on the one or more accelerometer signals.

Abstract: Systems and methods for clock synchronization are disclosed. A client synchronization system (CSS) may transmit RF pulses to a server CSS over micrometeorite ionization trail (MMIT) channels, and may receive RF pulses from the server CSS over MMIT channels, each received RF pulse following transmitted RF pulse. The client CSS may receive from the server CSS over MMIT channels measurement data including pulse arrival times at the server CSS. The measurement and transmission data may be correlated to identify RF-pulse pairs, each pairing a transmitted RF pulse received by the server CSS with a received RF pulse received from the server CSS, both over the same MMIT. TWTT analysis may be applied to timing data the pairs to compute time offsets between a client clock and a server clock. An analytical model of clock drift may be applied to the offsets to synchronize the client clock to the server clock.