Patents by Inventor David Wayne Berberich

David Wayne Berberich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Opiate reduction utilizing catalytic hydrogen transfer reaction
    Patent number: 8309727
    Abstract: An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: November 13, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David Wayne Berberich
  • Preparation of oxymorphone from oripavine
    Patent number: 8217175
    Abstract: An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1?-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: July 10, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David Wayne Berberich
  • Preparation of Oxymorphone from Oripavine
    Publication number: 20100113787
    Abstract: An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1?-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives.
    Type: Application
    Filed: March 14, 2008
    Publication date: May 6, 2010
    Inventors: Peter X. Wang, Tao Jiang, Gary l. Cantrell, David Wayne Berberich
  • Novel Opiate Reduction Utilizing Catalytic Hydrogen Transfer Reaction
    Publication number: 20100048905
    Abstract: An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method.
    Type: Application
    Filed: April 15, 2008
    Publication date: February 25, 2010
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David Wayne Berberich