Abstract: The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool.

Abstract: A technique is described for the application of three-dimensional (3D) relief to a substrate such as a ceramic tile using digital inkjet technology. A computer system receives information defining a relief pattern for forming the 3D relief using a digital inkjet printer. From the information, a feature vector is extracted comprising one or more features describing the 3D relief. A machine learning model is used to generate control commands based on the feature vector. The machine learning model is trained to generate the control commands to configure the digital inkjet printer to apply binder ink to a first region of a surface of the substrate. The applied binder ink is configured to form a protective layer over the first region of the surface of the substrate. The digital inkjet printer is configured to apply solvent ink to the surface of the substrate.

Abstract: This disclosure relates to the field of RNA to treat lung cancer, in particular non-small-cell lung carcinoma (NSCLC). Lung cancer is the third most frequent malignancy in women and the second most frequent malignancy in men. NSCLC accounts for about 85% of all lung cancers. Disclosed herein are compositions, uses, and methods for treatment of lung cancers. Administration of therapeutic RNAs to a patient having lung cancer disclosed herein can reduce tumor size, prolong time to progressive disease, and/or protect against metastasis and/or recurrence of the tumor and ultimately extend survival time.

Abstract: A transducer element for the detection of a transverse transition pressure of a shock wave includes a body that extends along a longitudinal axis and includes a nose portion and a measurement portion disposed adjacent the nose portion, which tapers along the longitudinal axis from the measurement portion until a nose end. The transducer is arranged with its longitudinal axis extending parallel to the propagation direction of the shock wave, with the nose portion facing the shock wave. The measurement portion contains at least three pressure transducers arranged in the body with respective pressure-sensitive pressure receiving surfaces arranged parallel to the longitudinal axis. The three pressure transducers are spaced apart from each other at a distance along the longitudinal axis. The transducer element is configured for determining the velocity and the acceleration of the shock wave.

Abstract: A method of providing ventricular support for a human patient during a high-risk percutaneous coronary intervention procedure includes inserting a mechanical circulatory support device into the vasculature of a human patient. The mechanical circulatory support device being movable between a compressed state and an expanded state. The mechanical circulatory support device is delivered into a heart of the human patient with the aid of a delivery assist device. Operating. The mechanical circulatory support device is operated for a support period. A clinically significant arrhythmia adverse event (AE) associated with the mechanical circulatory support device experiencing the arrhythmia event between the time of vascular access with the mechanical circulatory support device and removal of the mechanical circulatory support device from the vasculature is approximately 2.3%.

Abstract: A method of providing ventricular support for a human patient during a high-risk percutaneous coronary intervention procedure includes inserting a mechanical circulatory support device into the vasculature of a human patient. The mechanical circulatory support device being movable between a compressed state and an expanded state. The mechanical circulatory support device is delivered into a heart of the human patient with the aid of a delivery assist device. Operating. The mechanical circulatory support device is operated for a support period. A clinically significant arrhythmia adverse event (AE) associated with the mechanical circulatory support device experiencing the arrhythmia event between the time of vascular access with the mechanical circulatory support device and removal of the mechanical circulatory support device from the vasculature is approximately 2.3%.

Abstract: A user interface to a medical database stores context information from previous queries and uses the context information as part of information selection criteria for a current query, without requiring the users to fully specify the information selection criteria in each query. The context information is automatically stored as a profile for each user, for each group of users and, optionally, for each institution to which a user is affiliated. In response to a current user query, a combination of the information selection criterion currently entered by the user and one or more information selection criteria previously entered by the user, group and (optionally) institution is used to query the medical database. Optionally, a user's group membership may be automatically determined, based on current physical location of the user and potential groups, for example as estimated from a meeting calendar or signals received by a wireless access point.

Abstract: The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool.

Abstract: This disclosure relates to the field of RNA to treat lung cancer, in particular non-small-cell lung carcinoma (NSCLC). Lung cancer is the third most frequent malignancy in women and the second most frequent malignancy in men. NSCLC accounts for about 85% of all lung cancers. Disclosed herein are compositions, uses, and methods for treatment of lung cancers. Administration of therapeutic RNAs to a patient having lung cancer disclosed herein can reduce tumor size, prolong time to progressive disease, and/or protect against metastasis and/or recurrence of the tumor and ultimately extend survival time.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body disposed within a housing and defining tangential side faces arranged tangentially to the vertical axis, and a normal side face arranged normally to the vertical axis. A piezoelectric element is secured to one of the tangential side faces, and a seismic mass is secured to the piezoelectric element. A signal output is attached to the housing and includes a signal conductor spaced apart by an assembly gap from a tangential side face that is not attached to the piezoelectric element. The assembly gap extends perpendicularly to the vertical axis. The normal side face includes at least one main body output conductor spanning the assembly gap in a direction perpendicular to the vertical axis and directly contacting the signal conductor.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body defining tangential side faces arranged tangentially to the vertical axis, and normal side faces arranged normally to the vertical axis. The transducer includes at least a first piezoelectric element secured to one the three tangential side faces, and exactly one seismic mass is secured to the at least one piezoelectric element, which has a high sensitivity for a shear force exerted by the attached seismic mass along a principal tangential axis and a low sensitivity for a shear force exerted by the attached seismic mass along another one of the three axes.

Abstract: A technique is described for the application of three-dimensional (3D) relief to a substrate such as a ceramic tile using digital inkjet technology. A computer system receives information defining a relief pattern for forming the 3D relief using a digital inkjet printer. From the information, a feature vector is extracted comprising one or more features describing the 3D relief. A machine learning model is used to generate control commands based on the feature vector. The machine learning model is trained to generate the control commands to configure the digital inkjet printer to apply binder ink to a first region of a surface of the substrate. The applied binder ink is configured to form a protective layer over the first region of the surface of the substrate. The digital inkjet printer is configured to apply solvent ink to the surface of the substrate.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body defining tangential side faces arranged tangentially to the vertical axis, and normal side faces arranged normally to the vertical axis. The transducer includes at least a first piezoelectric element secured to one the three tangential side faces, and exactly one seismic mass is secured to the at least one piezoelectric element, which has a high sensitivity for a shear force exerted by the attached seismic mass along a principal tangential axis and a low sensitivity for a shear force exerted by the attached seismic mass along another one of the three axes.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body disposed within a housing and defining tangential side faces arranged tangentially to the vertical axis, and a normal side face arranged normally to the vertical axis. A piezoelectric element is secured to one of the tangential side faces, and a seismic mass secured to the piezoelectric element. A signal output is attached to the housing and includes a signal conductor spaced apart by an assembly gap from a tangential side face that is not attached to the piezoelectric element. The assembly gap extends perpendicularly to the vertical axis. The normal side face includes main body output conductors spanning the assembly gap in a direction perpendicular to the vertical axis and directly contacting the signal conductor.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body defining tangential side faces arranged tangentially to the vertical axis, and normal side faces arranged normally to the vertical axis. The transducer includes a converter unit, exactly three piezoelectric elements and three seismic masses. Each piezoelectric element generates piezoelectric charges transmitted to the converter unit, which is only and directly arranged on a normal side face of the main body or only on a support that is attached to a normal side face of the main body. Exactly one piezoelectric element is secured to each of the three tangential side faces, and exactly one seismic mass is secured to each of the three piezoelectric elements.

Abstract: An electric device for connection to a high voltage includes an active part having a magnetizable core and at least one winding arrangement, each surrounding a core section of the core and having windings inductively coupled together, forming cooling channels in the windings. A boiler is filled with insulating fluid and the active part is completely disposed therein. The boiler has at least one insulating fluid inlet and at least one insulating fluid outlet interconnected by a circulation system outside of the boiler having a cooling unit and a pump for circulating the insulating fluid. The electric device has improved cooling achieved by each insulating fluid inlet being connected to a distributing unit, which is disposed on one of the end sides of the winding assembly, via an insulating fluid line extending in the boiler, the distributing unit distributing cooled insulating fluid to the cooling channels.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body disposed within a housing and defining tangential side faces arranged tangentially to the vertical axis, and a normal side face arranged normally to the vertical axis. A piezoelectric element is secured to one of the tangential side faces, and a seismic mass is secured to the piezoelectric element. A signal output is attached to the housing and includes a signal conductor spaced apart by an assembly gap from a tangential side face that is not attached to the piezoelectric element. The assembly gap extends perpendicularly to the vertical axis. The normal side face includes at least one main body output conductor spanning the assembly gap in a direction perpendicular to the vertical axis and directly contacting the signal conductor.

Abstract: An electrical appliance for connecting to a high voltage includes an active part, which is provided with a magnetizable core and at least two winding assemblies, each surrounding a core section of the core and having windings that are inductively coupled to one another. The active part is entirely arranged a tank, which can be filled with an insulating fluid. The tank has two end casings and a central part arranged between the end casings. The electrical appliance is compact and has a low tare weight. The central part forms a hollow body for each winding assembly, through which a respective one of the core sections extends, which is surrounded by an associated winding assembly. The hollow bodies are connected to one another on the inside and only via the internal volume of the end casings.

Abstract: A new and distinct cultivar of Vaccinium plant named ‘DW18-04’ is disclosed, characterized by an upright and spreading plant habit, vigorous growth and semi-deciduous habit in Florida. Fruit is very firm, with an average firmness of 333 g/mm. The new variety shows tolerance for wet soil conditions. Fruit yield is exceptionally high, with fruit ripening early, with first harvest in mid-March in Central Florida. Fruit is globose, 18 to 25 mm in diameter with an attractive waxy coating. The new variety is a Vaccinium, and is normally used for commercial fruit production.