Patents by Inventor David Webster Wood

David Webster Wood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR ENHANCING STABILITY AND SOLUBILITY OF SPLIT-INTEINS
    Publication number: 20230174574
    Abstract: Disclosed herein is a protein purification system and methods of making such a system. Specifically, the invention relates to a method of immobilizing an N-terminal intein segment to a solid support, the method comprising: exposing an N-terminal intein segment to a cognate folding partner under conditions that promote association between the N-terminal intein and the cognate folding partner; immobilizing the N-terminal intein to a solid support; subjecting the N-terminal intein to conditions that disrupt association between the N-terminal intein and the cognate folding partner; and washing the solid support to remove non-bound material, thereby immobilizing an N-terminal intein segment to a solid support.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 8, 2023
    Inventors: David Webster WOOD, Joseph TARIS
  • Split intein compositions
    Patent number: 10669351
    Abstract: Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein segment, which can be immobilized, and a C-terminal intent segment, which has the property of being self-cleaving, and which can be attached to a protein of interest. Through the self-cleaving mechanism of the intein, the protein of interest can be purified.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: June 2, 2020
    Assignee: Ohio State Innovation Raundation
    Inventors: David Webster Wood, Changhua Shi
  • SPLIT INTEIN COMPOSITIONS
    Publication number: 20200024370
    Abstract: Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein segment, which can be immobilized, and a C-terminal intein segment, which has the property of being self-cleaving, and which can be attached to a protein of interest. Through the self-cleaving mechanism of the intein, the protein of interest can be purified.
    Type: Application
    Filed: August 28, 2018
    Publication date: January 23, 2020
    Inventors: David Webster Wood, Changhua Shi
  • Protein production systems and methods thereof
    Patent number: 10066027
    Abstract: Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein segment, which can be immobilized, and a C-terminal intein segment, which has the property of being self-cleaving, and which can be attached to a protein of interest. Through the self-cleaving mechanism of the intein, the protein of interest can be purified.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: September 4, 2018
    Assignee: Ohio State Innovation Foundation
    Inventors: David Webster Wood, Changhua Shi
  • PROTEIN PRODUCTION SYSTEMS AND METHODS THEREOF
    Publication number: 20160207965
    Abstract: Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein segment, which can be immobilized, and a C-terminal intein segment, which has the property of being self-cleaving, and which can be attached to a protein of interest. Through the self-cleaving mechanism of the intein, the protein of interest can be purified.
    Type: Application
    Filed: January 11, 2016
    Publication date: July 21, 2016
    Inventors: David Webster Wood, Changhua Shi