Abstract: A sleep training device is disclosed comprising certain electronic components, audio components, light-emitting diodes (LEDs), physical switches, a capacitive touch component, or a combination thereof. The sleep training device can have a housing configured to house the electronic components, the audio components, the LEDs, the capacitive touch component, and at least part of the physical switches. The sleep training device can receive an instruction to schedule a sleep program based on a set parameter from another device in wireless communication with the sleep training device, initiate the sleep program once the set parameter is met, and disable at least one of the physical switches and the capacitive touch component when the sleep program is initiated.

Abstract: This disclosure contemplates detecting antimicrobial heteroresistance to guide antibiotic or other antimicrobial therapy. In certain embodiments, this disclosure contemplates avoiding a monotherapy with antibiotics to which an individual bacterial isolate is heteroresistant, because this can lead to treatment failure. Thus, in certain embodiments, one uses a combination of antibiotics to which a bacterium is individually heteroresistant.

Abstract: In some embodiments, the systems and methods of the disclosure can rapidly and accurately determine the level of susceptibility of a sample to one or more antimicrobial agents using measured topography of that sample. The method may include providing a container including one or more sites having a sample and one or more concentrations of one or more antimicrobial agents. The method may include determining one or more metrics of at least a region of each site using the topographic surface profile for each site. The one or more metrics may include one or more of volumetric, distribution, spatial correlation, among others, or a combination thereof. The method may include determining one or more indices representing a level of susceptibility of the sample to the concentration of the one or more antimicrobial agents provided in each site using the one or more metrics for that site from one or more indices.

Abstract: This disclosure contemplates detecting antimicrobial heteroresistance to guide antibiotic or other antimicrobial therapy. In certain embodiments, this disclosure contemplates avoiding a monotherapy with antibiotics to which an individual bacterial pie isolate is heteroresistant, because this can lead to treatment failure. Thus, in certain embodiments, one uses a combination of antibiotics to which a bacterium is individually heteroresistant.

Abstract: A product includes a material having aluminum and at least one rare earth element (REE). The material includes the following microstructure features: at least 1 volume % particles of a phase of an aluminum-rare earth element alloy, the particles comprise at least 5 weight % of the at least one rare earth element, the particles have an average aspect ratio less than or equal to 5, and an average interparticle spacing between the particles is less than or equal to 1 ?m. A method includes forming a base material, the base material having aluminum and at least one rare earth element (REE), and working the base material to form a product.

Abstract: A multifunction device for improving sleep and methods of use are disclosed herein. The device can comprise an outer housing, a front panel, a front textile wrapped partially around the front panel, a plurality of LEDs within the outer housing, and an internal reflector coupled to the outer housing. The internal reflector can be configured to reflect light generated by the plurality of LEDs towards the front textile such that the light generated by the plurality of LEDs shines through the front panel and the front textile when a sleep-related program of the multifunction device is automatically initiated.

Abstract: Disclosed herein are embodiments of an Al—Ce—Cu alloy for use in additive manufacturing. The disclosed alloy embodiments provide fabricated objects, such as bulk components, comprising a heterogeneous microstructure and having good mechanical properties even when exposed to conditions used during the additive manufacturing process. Methods for making and using alloy embodiments also are disclosed herein.

Abstract: Production of a bulk Al-RE alloy body (product) using cast billets/ingots (cooling rates<100 C/s) or rapidly solidified Al-RE particulates (cooling rates 102-106° C./second) that have beneficial microstructural refinements that are further refined by subsequent consolidation to produce a consolidated bulk alloy product having excellent mechanical properties over a wide temperature range such as up to and above 230° C.

Abstract: A multifunction device for improving sleep and methods of use are disclosed herein. The device can comprise an outer housing, a front panel, a front textile wrapped partially around the front panel, a plurality of LEDs within the outer housing, and an internal reflector coupled to the outer housing. The internal reflector can be configured to reflect light generated by the plurality of LEDs towards the front textile such that the light generated by the plurality of LEDs shines through the front panel and the front textile when a sleep-related program of the multifunction device is automatically initiated.

Abstract: Methods and systems are provided that include an order and/or quote engine that automatically adjusts bid, ask, or any other type of order prices to reflect some or all of the costs associated with a trade in an underlying item between a particular party receiving the order or orders accounting for specific costs associated with the party receiving the orders and in certain instances specific costs between the party receiving the order and the party submitting the order.

Abstract: Production of a bulk Al-RE alloy body (product) using cast billets/ingots (cooling rates <100 C/s) or rapidly solidified Al-RE particulates (cooling rates 102-106° C./second) that have beneficial microstructural refinements that are further refined by subsequent consolidation to produce a consolidated bulk alloy product having excellent mechanical properties over a wide temperature range such as up to and above 230° C.

Abstract: Method and system may include receiving orders for an item from computing devices associated with internal users and from computing devices associated with external users; determining a best bid and a best offer from the orders from the internal users and the external orders; and causing an interface screen to be displayed at a user computing device, the interface screen comprising a shared order book for the item including a listing of the orders from the internal users and the external users sorted by price, the shared order book arranged in a set of bid side and a set of ask side columns, each set of columns comprising at least one price column and at least one size column, and at least one column indicating a source of at least one of each of an order from an internal user and an order for an external user.

Abstract: Methods and systems are provided that include an order and/or quote engine that automatically adjusts bid, ask, or any other type of order prices to reflect some or all of the costs associated with a trade in an underlying item between a particular party receiving the order or orders accounting for specific costs associated with the party receiving the orders and in certain instances specific costs between the party receiving the order and the party submitting the order.

Abstract: Disclosed herein are embodiments of an Al—Ce—Ni alloy for use in additive manufacturing. The disclosed alloy embodiments provide fabricated objects, such as bulk components, comprising a heterogeneous microstructure and having good mechanical properties even when exposed to conditions used during the additive manufacturing process. Methods for making and using alloy embodiments also are disclosed herein.

Abstract: Disclosed herein are embodiments of an Al—Ce—Ni alloy for use in additive manufacturing. The disclosed alloy embodiments provide fabricated objects, such as bulk components, comprising a heterogeneous microstructure and having good mechanical properties even when exposed to conditions used during the additive manufacturing process. Methods for making and using alloy embodiments also are disclosed herein.

Abstract: A product includes a material having: nickel and at least one rare earth element. The at least one rare earth element is present in the material in a weight percentage in a range of about 2% to about 20% relative to a total weight of the material. A method includes forming a material comprising an alloy of nickel and at least one rare earth element. The at least one rare earth element is present in the material in a weight percentage in a range of about 2% to about 20% relative to a total weight of the material.

Abstract: Disclosed herein are embodiments of aluminum-based alloys having improved intergranular corrosion resistance. Methods of making and using the disclosed alloy embodiments also are disclosed herein.

Abstract: An alloy includes aluminum, a rare earth element, and an alloying element selected from the following: Si, Cu, Mg, Fe, Ti, Zn, Zr, Mn, Ni, Sr, B, Ca, and a combination thereof. The aluminum (Al), the rare earth element (RE), and the alloying element are characterized by forming at least one form of an intermetallic compound. An amount of the rare earth element in the alloy is in a range of about 1 wt. % to about 12 wt. %, and an amount of the alloying element in the alloy is greater than an amount of the alloying element present in the intermetallic compound.