Abstract: The present invention is directed to a physical therapy device capable of folding into a single portable device comprising a frame comprising a first lengthwise bar and a second lengthwise bar; and a first transverse bar and a second transverse bar. The frame is configured to be adjusted between an unfolded configuration for use and a folded configuration for storage; a first set of stanchions, each coupled to at least a portion of the first lengthwise bar; and a first handrail coupled to a top portion of each of the first set of stanchions. In the folded configuration, the first lengthwise bar is parallel to the second lengthwise bar, and the first and second transverse bars are configured to hinge such that each bar folds towards a center region of the frame to be substantially parallel to the first and second lengthwise bars.

Abstract: Designed coronavirus polypeptide sequences are described, and their use as vaccines against viruses of the coronavirus family. The designed sequences include designed coronavirus spike (S) proteins and fragments thereof, including designed full-length S protein sequences SEQ ID NOs: 88, 87, and 53. Designed coronavirus envelope (E), membrane (M), and nucleocapsid (N) protein sequences are also described, and their use as vaccines. Nucleic acid molecules encoding the polypeptides, vectors, fusion proteins, pharmaceutical compositions, cells, and their use as vaccines against viruses of the coronavirus family are also described.

Abstract: Polypeptides, nucleic acid molecules, vectors, cells, fusion proteins, pharmaceutical compositions, combined preparations, and their use as vaccines against influenza are described. The polypeptides comprise a haemagluttinin subtype 5 (H5) globular head domain, and optionally a haemagluttinin stem domain, wherein the polypeptide comprises an amino acid sequence in which an amino acid residue at a position corresponding to residue position 144 or 145 of a wild-type H5 globular head domain has been deleted, or wherein the polypeptide comprises an amino acid sequence with an E amino acid residue at a position corresponding to residue position 238 of a wild-type H5 globular head domain.

Abstract: In one implementation, a system to provide a secure crossing network for trading digital blockchain assets outside of an exchange can include a crossing network program that is configured to provide a crossing network for the digital blockchain assets and a computer system with a secure enclave that is configured to provide the trusted execution environment within which processing of programs is secure from observation and manipulation by other operations outside of the secure enclave. The execution of the crossing network program in the secure enclave receiving, from client devices, crossing network orders to trade assets within the crossing network; matching at least a portion of the crossing network orders in an order book; obtaining, using a pricing oracle, pricing information for transactions in the exchange; and determining a reference price for the matched orders within the crossing network based on the pricing information from the exchange.

Abstract: Designed coronavirus polypeptide sequences are described, and their use as vaccines against viruses of the coronavirus family. The designed sequences include designed coronavirus spike (S) proteins and fragments thereof, including designed S protein receptor binding domain (RBD) sequence SEQ ID NO:17, designed truncated S protein sequence SEQ ID NO:15, and designed full length S protein sequence SEQ ID NO:13. Designed coronavirus envelope (E), membrane (M), and nucleocapsid (N) protein sequences are also described, and their use as vaccines. Nucleic acid molecules encoding the polypeptides, vectors, fusion proteins, pharmaceutical compositions, cells, and their use as vaccines against viruses of the coronavirus family are also described.

Abstract: The present invention is directed to a physical therapy device capable of folding into a single portable device comprising a frame comprising a first lengthwise bar and a second lengthwise bar; and a first transverse bar and a second transverse bar. The frame is configured to be adjusted between an unfolded configuration for use and a folded configuration for storage; a first set of stanchions, each coupled to at least a portion of the first lengthwise bar; and a first handrail coupled to a top portion of each of the first set of stanchions. In the folded configuration, the first lengthwise bar is parallel to the second lengthwise bar, and the first and second transverse bars are configured to hinge such that each bar folds towards a center region of the frame to be substantially parallel to the first and second lengthwise bars.

Abstract: In one implementation, a system to provide a secure crossing network for trading digital blockchain assets outside of an exchange can include a crossing network program that is configured to provide a crossing network for the digital blockchain assets and a computer system with a secure enclave that is configured to provide the trusted execution environment within which processing of programs is secure from observation and manipulation by other operations outside of the secure enclave. The execution of the crossing network program in the secure enclave receiving, from client devices, crossing network orders to trade assets within the crossing network; matching at least a portion of the crossing network orders in an order book; obtaining, using a pricing oracle, pricing information for transactions in the exchange; and determining a reference price for the matched orders within the crossing network based on the pricing information from the exchange.

Abstract: Polypeptides for use in vaccines against influenza are described. The polypeptides comprise a haemagglutinin subtype 5 (H5) globular head domain, and optionally a haemagglutinin stem domain, with the following amino acid residues at positions 156, 157, 171, 172, and 205 of the head domain: •156: R; •157: P or S, preferably P; •171: D or N; •172: T or A, preferably T; and •205: K or R, preferably K Nucleic acid molecules encoding the polypeptides, vectors, cells, fusion proteins, and pharmaceutical compositions are also described.

Abstract: The present invention is directed to a physical therapy device capable of folding into a single portable device comprising a frame comprising a first lengthwise bar and a second lengthwise bar; and a first transverse bar and a second transverse bar. The frame is configured to be adjusted between an unfolded configuration for use and a folded configuration for storage; a first set of stanchions, each coupled to at least a portion of the first lengthwise bar; and a first handrail coupled to a top portion of each of the first set of stanchions. In the folded configuration, the first lengthwise bar is parallel to the second lengthwise bar, and the first and second transverse bars are configured to hinge such that each bar folds towards a center region of the frame to be substantially parallel to the first and second lengthwise bars.

Abstract: A method and apparatus or system are disclosed for a procedure with minimal or no fluoroscopy, for example an electrosurgical procedure, and which uses a three dimensional mapping system. The procedure typically involves electrical measurement of the electrode of a needle to determine its position. Some embodiments further include intracardiac echocardiography (ICE) for tracking devices. The apparatus includes a needle with a tip electrode, an electroanatomical mapping (EAM) system, and an electrical generator, wherein a switching device is used to restrictively electrically connect the needle to only one of the mapping system or generator at a given time.

Abstract: An improved pump manual rolling system and method of use. The improved pump manual rolling system can include a pump manual rolling device that has a torque wheel that is bolted to and remains on the pump crankshaft; a torque wheel cover that bolts to, and remains on, a non-rotating part of the pump, pump component (such as a the belt guard cover), or an independent stand, and a detached handle with or without a key to both activate and select ratchet operation direction.

Abstract: In one embodiment, a change data monitoring system may gather change data from multiple data sources each with a different proprietary source format. The change data monitoring system may receive a change data report having a change data set describing changes made to an online system from a data source of a data source set tracking the online system using multiple proprietary source formats. The change data monitoring system may convert the change data set from a proprietary source format to a standardized data presentation format. The change data monitoring system may present the change data set to a user in the standardized data presentation format.

Abstract: Methods of administering biocide to industrial water in an industrial water process are provided. The methods may be carried out using a reactor for generating an oxidative biocide and delivering the oxidative biocide to a liquid stream. The reactor includes, among other things, a reaction chamber and packing positioned within the reaction chamber to facilitate mixing of at least two reactants.

Abstract: Securely sharing a Transport Layer Security (TLS) session with one or more trusted devices. In one embodiment, a method may include establishing a TLS session between a client device and a server device, communicating encrypted messages that are encrypted using encryption keys between the client device and the server device, and intercepting and decrypting one or more of the encrypted messages at a trusted device using the encryption keys. In this embodiment, the establishing of the TLS session may include negotiating a master secret, establishing a secure channel between the trusted device and the client device or the server device, sending, from the client device or the server device, the master secret to the trusted device over the secure channel, and employing the master secret at the client device, at the server device, and at the trusted device to generate, for the TLS session, the encryption keys.

Abstract: A system and method for handling a digital electronic flow between a first and second entity in which a flow policy is determined that is to be applied to the flow and the flow is then directed along a path in accordance with the policy. An ID is supplied for each flow and a tag associated with each flow which indicates the policy to be applied to its associated flow. Flows are also associated with one another, with associated flows having associated policies. In particular the flow may be processed or forwarded. The path may include a graph structure and virtual applications.

Abstract: A projectile for conventional firearms includes a cavity with a conical or ogive surface, and an internal cavity into which is disposed an explosive material, such as a low explosive material. The tip of the projectile includes a reservoir into which is disposed an initiator, detonator, or primer material. According to some embodiments a pin is disposed ahead of the initiator, while according to others, deformable material is placed ahead of the initiator, so that impact of the projectile onto a target shocks the initiator into deflagration, which propagates into the explosive material, to fragment the projectile or for pyrotechnic effects, or both. According to additional embodiments, the explosive may be a binary explosive activated by common substances available separately to a user, so that the product itself may be legally sold, shipped, and stored in a safe and stable state and thus incur fewer regulatory burdens.

Abstract: Securely sharing a Transport Layer Security (TLS) session with one or more trusted devices. In one embodiment, a method may include establishing a TLS session between a client device and a server device, communicating encrypted messages that are encrypted using encryption keys between the client device and the server device, and intercepting and decrypting one or more of the encrypted messages at a trusted device using the encryption keys. In this embodiment, the establishing of the TLS session may include negotiating a master secret, establishing a secure channel between the trusted device and the client device or the server device, sending, from the client device or the server device, the master secret to the trusted device over the secure channel, and employing the master secret at the client device, at the server device, and at the trusted device to generate, for the TLS session, the encryption keys.

Abstract: A fiber optic sensor system for measuring electric currents, such as the associated with geomagnetic disturbances and electromagnetic pulses. A fiber optic sensor system is disclosed including at least one light source, one or more first optical fibers having a first end arranged to receive light from the light source(s) and transmit the light to at least one of the sensor, and one or more second optical fibers arranged to receive reflected light from the fiber optic sensors and transmit the reflected light to a light sensing element. Using the sensors and the system, it is possible to measure currents within a structure of interest, such as upon the grounded neutral of an electric power transformer, take multiple measurements of current at the same piece of equipment or at multiple locations, or measure current and other physical phenomena on separate materials or structures.

Abstract: A system and method for handling a digital electronic flow between a first and second entity in which a flow policy is determined that is to be applied to the flow and the flow is then directed along a path in accordance with the policy. An ID is supplied for each flow and a tag associated with each flow which indicates the policy to be applied to its associated flow. Flows are also associated with one another, with associated flows having associated policies. In particular the flow may be processed or forwarded. The path may include a graph structure and virtual applications.

Abstract: A system and method for handling a digital electronic flow between a first and second entity in which a flow policy is determined that is to be applied to the flow and the flow is then directed along a path in accordance with the policy. An ID is supplied for each flow and a tag associated with each flow which indicates the policy to be applied to its associated flow. Flows are also associated with one another, with associated flows having associated policies. In particular the flow may be processed or forwarded. The path may include a graph structure and virtual applications.