Abstract: The present invention relates to solenopsin A and its analogs for use as angiogenesis inhibitors. The present compounds unexpectedly exhibit good activity as angiogenesis inhibitors, which find use as antitumor/anticancer agents as well as to treat a number of conditions or disease states in which angiogenesis is a factor.

Abstract: The present invention relates to solenopsin A and its analogs for use as angiogenesis inhibitors. The present compounds unexpectedly exhibit good activity as angiogenesis inhibitors, which find use as antitumor/anticancer agents as well as to treat a number of conditions or disease states in which angiogenesis is a factor.

Abstract: The present invention relates to solenopsin alkaloid derivatives which are trans-2,6-disubstituted piperidines according to the structure: wherein R1 and R2 are selected from a C1 to C20 saturated or unsaturated linear, cyclic or branch-chained substituted or unsubstituted hydrocarbon group or a substituted or unsubstituted aromatic group, or an ester group. In certain preferred embodiments, where R1 or R2 contains an unsaturated group, such as an alkenyl group, the double bond in the alkenyl group preferably is found in the hydrocarbon chain between the carbon atom bonded to the piperidine ring and the adjacent carbon atom (&agr; and &bgr; carbons).

Abstract: A semiconductor chip for processing or storing information and a system comprising a plurality of semiconductor chips for processing or storing information. In one form of the invention each chip includes clock input and output circuitry for receiving and transmitting signals of a first frequency and transmission circuitry for receiving and transmitting data. The transmission circuitry is capable of sampling the data at a second clock frequency which is less than the first clock frequency. Circuit components are coupled to the clock circuitry and transmission circuitry for processing the data. In another form of the invention a semiconductor chip comprising clock input and output circuitry, transmission circuitry and circuit components for processing data further includes input circuitry for selecting a variable delay between the time data is received onto the chip and transmitted from the chipIn a preferred embodiment of the invention the semiconductor chip includes a memory array for storing data.