Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A method of writing data to a transparent substrate comprises forming a first voxel by focusing a first laser pulse on a first location in a transparent substrate; and forming a second voxel by focusing a second laser pulse on a second location in the transparent substrate. The first laser pulse and the second laser pulse have different amplitudes, resulting in the first and second voxels having different strengths. Also provided are a system useful for implementing the method; an optical data storage medium obtainable by the method; and a method of reading data from the optical data storage medium.

Abstract: A method includes receiving, by a processing device of a content sharing platform, a request for desired content from a client device, the content being stored in a content delivery network (CDN). The method further includes generating, based on data available to the content sharing platform, a partial trust metric associated with the client device, wherein the partial trust metric is to be used by a CDN server to make a decision regarding access to the desired content by the client device. The method further includes generating a response to the content request, wherein the response comprises one or more resource locators for accessing the desired content in the CDN, and the partial trust metric. The method further includes sending the response to the client device to enable the client device to request the desired content from the CDN server using the resource locator(s) and the partial trust metric.

Abstract: Systems and methods disclosed herein are directed to determining serum potassium levels of a patient wearing a biosensing device. A first such method includes operations of capturing a first energy measurement reading by an energy detecting element of an optical sensor, wherein the optical sensor is a component of a biosensing device, and wherein the biosensing device is disposed on a skin surface of the patient, performing a feature extraction on the first energy measurement reading resulting in a feature vector representative of volumetric variations in blood flow of the patient, deploying a trained machine learning model configured to take the feature vector as input and determine a serum potassium level classification of the patient at a time corresponding to when the first energy measurement reading was captured, and generating a graphic user interface (GUI) that displays the serum potassium level classification.

Abstract: Systems and methods of the disclosure are directed to the personalization of machine learning models configured to generate patient health-related predictions for a patient wearing a biosensing device. The biosensing device may be mounted over or proximate to a vessel of a patient enabling biosensing data to be obtained or captured by the biosensing device. Particular implementations of the disclosure are directed to training a machine learning model to generate patient health-related predictions for a patient and retraining the machine learning model over time using data captured by the biosensing device worn by the patient to personalize the machine learning model to the individual patient. As a result, the personalized machine learning model enables the provision of precision medicine through the tailoring of the historical data on which the machine learning is trained.

Abstract: A system and method are disclosed that include a wearable biosensing device mounted over or proximate to a vessel of a patient enabling biosensing data to be obtained or captured by the wearable biosensing device. Operations of the method or performed by logic of the system are directed at determining patient health-related predictions of a first patient and include obtaining patient health data including at least biosensing data obtained from a wearable biosensing device of the first patient, wherein the biosensing data includes one or more of raw signals captured by the wearable biosensing device or a first metric provided by the wearable biosensing device, evaluating the patient health data by applying one or more machine learning techniques that receive the patient health data as input resulting in a first patient health-related prediction, and generating a graphical user interface illustrating the first patient health-related prediction.

Abstract: Handling packet flows in a communications network includes receiving a first packet that is part of a first unidirectional packet flow; determining whether the first packet is from a packet flow that has been assigned to any one of a plurality of security application instances; processing the first packet by one of the plurality of security application instances; determining whether a first flow identifier for the processed first packet is in a first flow database; recording the first flow identifier for the processed first packet in the first flow database upon determining that the first flow identifier for the processed first packet is not in the first flow database; and recording in a second flow database (i) a second flow identifier for a return packet flow of the first unidirectional packet flow, and (ii) a first security application instance identifier that processed the first packet.

Abstract: A content viewing estimation system including a module to receive a time measurement of how long at least part of a content item was rendered by an end-user rendering unit and outputted for display to an audio-visual outputting arrangement during a time window, a module to determine user interaction with the end-user rendering unit and/or the audio-visual outputting arrangement, a module to calculate an average content item duration of a plurality of content items rendered by the end-user rendering unit during the time window, and a module to estimate viewing by the user of the at least part content item such that if user interaction was not determined during the time window then time attributed to the viewing of the at least part content item is set to the minimum of a capping limit, the time measurement, and the average content item duration. Related apparatus and methods are also described.

Abstract: A content viewing estimation system including a module to receive a time measurement of how long at least part of a content item was rendered by an end-user rendering unit and outputted for display to an audio-visual outputting arrangement during a time window, a module to determine user interaction with the end-user rendering unit and/or the audio-visual outputting arrangement, a module to calculate an average content item duration of a plurality of content items rendered by the end-user rendering unit during the time window, and a module to estimate viewing by the user of the at least part content item such that if user interaction was not determined during the time window then time attributed to the viewing of the at least part content item is set to the minimum of a capping limit, the time measurement, and the average content item duration. Related apparatus and methods are also described.

Abstract: A method for switching from playing a first compressed data segment to playing a second compressed recorded data segment, the method including playing an uncompressed copy of a start of the second compressed recorded data segment upon switching from playing the first compressed data segment, decoding the second compressed recorded data segment from a preceding random access point, the preceding random access point preceding, in the second compressed recorded data segment, a point at which playing is to be switched to the second compressed recorded data segment, stopping the decoding of the second compressed recorded data segment when reaching a point beyond a point currently being played in the uncompressed copy, and switching to playing the second compressed recorded data segment when playing the uncompressed copy of a start of the second compressed recorded data segment reaches the point at which the decoding of the second compressed recorded data segment was stopped.

Abstract: A system for preparing a digital video stream for zooming by a content consumer system, including a video frame processor to prepare a plurality of video frames of the digital video stream, a zoom location processor to prepare a plurality of zoom location indicators in the digital video stream, each of the zoom location indicators including an element indicative of a least one horizontal position and at least one vertical position in the video frames, and a stream processor to temporally synchronize the zoom location indicators and the video frames in the digital video stream, such that the video frames are available to be zoomed by the content consumer system based on the zoom location indicators during playback of the digital video steam. Related apparatus and methods are also described.

Abstract: A system for preparing a digital video stream for zooming by a content consumer system, including a video frame processor to prepare a plurality of video frames of the digital video stream, a zoom location processor to prepare a plurality of zoom location indicators in the digital video stream, each of the zoom location indicators including an element indicative of a least one horizontal position and at least one vertical position in the video frames, and a stream processor to temporally synchronize the zoom location indicators and the video frames in the digital video stream, such that the video frames are available to be zoomed by the content consumer system based on the zoom location indicators during playback of the digital video steam. Related apparatus and methods are also described.

Abstract: A method for switching from playing a first compressed data segment to playing a second compressed recorded data segment, the method including playing an uncompressed copy of a start of the second compressed recorded data segment upon switching from playing the first compressed data segment, decoding the second compressed recorded data segment from a preceding random access point, the preceding random access point preceding, in the second compressed recorded data segment, a point at which playing is to be switched to the second compressed recorded data segment, stopping the decoding of the second compressed recorded data segment when reaching a point beyond a point currently being played in the uncompressed copy, and switching to playing the second compressed recorded data segment when playing the uncompressed copy of a start of the second compressed recorded data segment reaches the point at which the decoding of the second compressed recorded data segment was stopped.

Abstract: A controller for use with a guidewire, such as a vascular guidewire, provides a mechanism for gripping and applying a torque to the guidewire without the need to thread the guidewire axially through the controller and at a location close to a point of access of the guidewire. In one embodiment, the controller includes a side-access, multi-part assembly including a collet or other gripping element that applies a uniform radially inward force on the guidewire. In another embodiment, for use with guidewires having active electrically controllable elements, the controller integrally or removably incorporates a switch or other mechanism to initiate an energized state. The controller thereby permits ergonomic, single-handed control of an electronically steerable guidewire, including axially displacing, torquing and steering the guidewire.

Abstract: A method of use for a vascular guidewire and related equipment involves, in one embodiment, control of the guidewire from a location close to the entry point of the vasculature (or other entry point). It also permits convenient loading and unloading of coaxial equipment over the guidewire and it can accommodate doing so by removably and conveniently engaging a proximal end of the guidewire, taking into account the diameter of the proximal portion not being appreciably greater than any other portion of the guidewire.

Abstract: A controller for use with a guidewire, such as a vascular guidewire, provides a mechanism for gripping and applying a torque to the guidewire without the need to thread the guidewire axially through the controller and at a location close to a point of access of the guidewire. In one embodiment, the controller includes a side-access, multi-part assembly including a collett or other gripping element that applies a uniform radially inward force on the guidewire. In another embodiment, for use with guidewires having active electrically controllable elements, the controller integrally or removably incorporates a switch or other mechanism to initiate an energized state. The controller thereby permits, among other advantages, ergonomic, single-handed control of an electronically steerable guidewire, including axially displacing, torquing and steering the guidewire.

Abstract: An energizer for use with a guidewire, such as a vascular guidewire, in one embodiment engages a proximal end of the guidewire and applies energy to be transmitted to a distal portion of the guidewire. A jack or other receptacle accommodates, in a releasably secured fashion, a proximal portion of the guidewire having a diameter that is not substantially larger than, but preferably is equal to or less than, the maximal diameter associated with the guidewire. The jack may be structured so that designated portions of the proximal end of the guidewire will be disposed in selective contact with corresponding portions of the jack in order to permit, for example, an electrical potential to be applied across such portions, thereby energizing an electrically controllable part of the guidewire, such as a steering mechanism. In this manner, the energizer permits rapid engagement and disengagement of a proximal portion of the guidewire.

Abstract: A vascular guidewire in an embodiment of the present invention, having such features as uniform diameter, low-profile cross section over its length and a distal tip capable of deflection and variable configurations, provides a range of advantages. A variable distal tip of shape-memory alloy deflects into varied configurations when remotely actuated. Such actuation, according to an aspect of the present invention, can be by way of a side entry, easily repositioned, single-handed controller that allows both rotational control of the guidewire and control of the variable tip. In another aspect, a longitudinal element in the guidewire, such as an exterior wire wrap, can provide dual functionality, including structural support as well as an electrical path for use in energizing, and thus deflecting, the distal tip.

Abstract: A gas fire with coal effect has a gas manifold or box divided into separate gas compartments with gas outlets therefrom and is formed with illumination apertures. The coal effect which is ceramic and has flame apertures therethrough is precisely positioned on the gas manifold or box by locating formation so that the gas outlets and flame apertures are correctly relatively disposed to avoid "sooting".An electric lamp (preferably two) is disposed forwardly and downwardly of, and preferably centrally of, the gas manifold or box and the coal effect to provide an instantaneous "glow" effect when illuminated. This latter effect can be attained with or without flames being present.